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Study on transmission of sporadic cerebral amyloid angiopathy

Research Project

Project/Area Number 15K15336
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionKanazawa University

Principal Investigator

YAMADA Masahito  金沢大学, 医学系, 教授 (80191336)

Co-Investigator(Kenkyū-buntansha) 濱口 毅  金沢大学, 附属病院, 講師 (70452109)
Co-Investigator(Renkei-kenkyūsha) ONO Kenjiro  昭和大学, 医学部, 教授 (70377381)
SAKAI Kenji  金沢大学, 附属病院, 助教 (00572306)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords脳アミロイドアンギオパチー / アミロイドβ蛋白 / 伝播 / 剖検脳 / アルツハイマー病
Outline of Final Research Achievements

To examine a hypothesis that sporadic cerebral amyloid angiopathy (CAA) can be transmitted from humans to humans through CAA-specific amyloid β-protein (Aβ) strain, we performed transmission experiments to R1.40 APP transgenic mice with brain samples from patients with CAA without Alzheimer's disease (AD) (n = 3), AD with CAA (n = 3), AD without CAA (n = 3), and no AD/CAA (n = 3). Western blot of brains from the mice inoculated with the human brain samples presented with Aβ(n = 9)with Aβ40 (n = 3) or Aβ42 predominance (n = 6). Immunohistochemically, all the mice showed Aβ deposition in the brain with remarkable variations of Aβ42/Aβ40 ratios [Aβ42 immunoreactive areas (%)/Aβ40 immunoreactive areas (%)]. Severity of CAA correlated with Aβ40 immunoreactive areas (%). Study on correlations in the pattern of Aβ deposition between human and mouse brains is ongoing.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (1 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] チュービンゲン大学(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チュービンゲン大学(ドイツ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] チュービンゲン大学(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Cerebral amyloid angiopathy-related microbleeds and cerebrospinal fluid biomarkers in alzheimer's disease.2017

    • Author(s)
      Noguchi-Shinohara M, Komatsu J, Samuraki M, Matsunari I, Ikeda T, Sakai K, Hamaguchi T, Ono K, Nakamura H, Yamada M.
    • Journal Title

      J Alzheimers Dis

      Volume: 55 Issue: 3 Pages: 905-913

    • DOI

      10.3233/jad-160651

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of transthyretin- and Aβ-type cerebral amyloid angiopathy in a patient with hereditary transthyretin V30M amyloidosis2017

    • Author(s)
      Sakai K, Asakawa M, Takahashi R, Ishida C, Nakamura R, Hamaguchi T, Ono K, Iwasa K, Yamada M
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 381 Pages: 144-146

    • DOI

      10.1016/j.jns.2017.08.3240

    • NAID

      120006375106

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳アミロイドアンギオパチー2017

    • Author(s)
      坂井健二、山田正仁
    • Journal Title

      日本医師会雑誌

      Volume: 146(特別号(1))

    • Related Report
      2017 Annual Research Report
  • [Presentation] Cerebral amyloid angiopathy in Alzheimer's disease2017

    • Author(s)
      Sakai K, Noguchi-Shinohara M, Yamada M
    • Organizer
      第36回日本認知症学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 最新アミロイドーシスのすべて2017

    • Author(s)
      坂井健二、山田正仁、玉岡 晃
    • Total Pages
      264
    • Publisher
      医歯薬出版
    • ISBN
      9784263731758
    • Related Report
      2017 Annual Research Report
  • [Book] 別冊「医学のあゆみ」 アミロイドーシスの最新情報2017

    • Author(s)
      坂井健二、山田正仁
    • Total Pages
      160
    • Publisher
      医歯薬出版
    • Related Report
      2017 Annual Research Report
  • [Book] 必携脳卒中ハンドブック2017

    • Author(s)
      濵口 毅、山田正仁
    • Total Pages
      476
    • Publisher
      診断と治療社
    • ISBN
      9784787822369
    • Related Report
      2017 Annual Research Report
  • [Remarks] 金沢大学大学院医薬保健学総合研究科神経内科 医学専攻 脳老化・神経病態学(神経内科学)ホームページ

    • URL

      http://neurology.w3.kanazawa-u.ac.jp

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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