Analysis of temporal and spatial brain circuit using real-time simultaneous electroencephalography and functional magnetic resonance imaging

• Project/Area Number: 15K15338
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: WATANABE Hirohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)
• Co-Investigator(Kenkyū-buntansha): Bagarinao E. 名古屋大学, 脳とこころの研究センター, 特任准教授 (00443218) ; 祖父江 元 名古屋大学, 医学系研究科, 特任教授 (20148315) ; 伊藤 瑞規 名古屋大学, 医学部附属病院, 講師 (50437042) ; 前澤 聡 名古屋大学, 脳とこころの研究センター, 特任准教授 (90566960)
• Co-Investigator(Renkei-kenkyūsha): HOSHIYAMA Minoru 名古屋大学, 脳とこころの研究センター, 教授 (30270482) ; MORI Daisuke 名古屋大学, 脳とこころの研究センター, 特任准教授 (00381997) ; TANABE Hiroki 名古屋大学, 環境科学研究科, 教授 (20414021)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: MRI / 脳波 / 高次脳機能 / リアルタイム / 認知症 / てんかん / 機能的MRI / ネットワーク / パーキンソン病 / 脳腫瘍

Outline of Final Research Achievements

We aim to resolve the spatiotemporal changes in brain activation using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. We proposed a method that employed whole scalp EEG data to generate regressors needed for the analysis of fMRI using the general linear model. Using simultaneous EEG-fMRI recordings from healthy subjects and patients with epilepsy, we obtained activation maps showing brain regions that were consistent with working memory task and suspected or confirmed sources of the epileptogenic activity. We also identified spatiotemporal activation patterns during epileptic spikes that include sequential activation of multiple brain regions involved, shifting location of the peak activation, and local spreading of activated regions. These findings demonstrated the efficacy of the method in resolving rapidly changing activation patterns with sub-second temporal resolution observed during cognitive task and epileptic spikes.

Research Products

• [Journal Article] Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. (2017)
  • Author(s): Riku Y., Watanabe H., Yoshida M., Mimuro M., Iwasaki Y., Masuda M., Ishigaki S., Katsuno M., Sobue G.
  • Journal Title: J Neuropathol Exp Neurol Volume: in press Issue: 8 Pages: 801-811
  • DOI: 10.1093/jnen/nlw053
  • Peer Reviewed
• [Journal Article] Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. (2016)
  • Author(s): Masuda, M., Senda, J., Watanabe, H., Epifanio, B., Tanaka, Y., Imai, K., Riku, Y., Li, Y., Nakamura, R., Ito, M., Ishigaki, S., Atsuta, N., Koike, H., Katsuno, M., Hattori, N., Naganawa, S., and Sobue, G.
  • Journal Title: Amyotroph Lateral Scler Frontotemporal Degener Volume: 17 Issue: 7-8 Pages: 571-579
  • DOI: 10.1080/21678421.2016.1211151
  • Peer Reviewed / Open Access
• [Journal Article] HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease (2016)
  • Author(s): Fujita, K., Motoki, K., Tagawa, K., Chen, X., Hama, H., Nakajima, K., Homma, H., Tamura, T., Watanabe, H., Katsuno, M., Matsumi, C., Kajikawa, M., Saito, T., Saido, T., Sobue, G., Miyawaki, A., Okazawa, H.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 31895-31895
  • DOI: 10.1038/srep31895
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy. (2016)
  • Author(s): Hijikata Y., Katsuno M., Suzuki K., Hashizume A., Araki A., Yamada S., Inagaki T., Iida M., Noda S., Nakanishi H., Banno H., Mano T., Hirakawa A., Adachi H., Watanabe H., Yamamoto M., Sobue G.
  • Journal Title: Ann Clin Transl Neurol Volume: 3 Issue: 7 Pages: 537-546
  • DOI: 10.1002/acn3.324
  • Peer Reviewed / Open Access
• [Journal Article] A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN. (2016)
  • Author(s): Watanabe H, Atsuta N, Hirakawa A, Nakamura R, Nakatochi M, Ishigaki S, Iida A, Sobue G.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: in press Issue: 8 Pages: 851-8
  • DOI: 10.1136/jnnp-2015-311541
  • Peer Reviewed
• [Journal Article] Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder (2015)
  • Author(s): Tsuboi, T. Watanabe, H. Tanaka, Y. Ohdake, R. Yoneyama, N. Hara, K. Ito, M. Hirayama, M. Yamamoto, M. Fujimoto, Y. Kajita, Y. Wakabayashi, T. Sobue, G.
  • Journal Title: J Neural Transm (Vienna) Volume: 122 Issue: 12 Pages: 1663-72
  • DOI: 10.1007/s00702-015-1436-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Skin-related dysautonomia and bladder dysfunction in PD. (2016)
  • Author(s): Watanabe H, Sobue G.
  • Organizer: 4th World Parkinson Congress PARALLEL SESSION SPRACTICAL MANAGEMENT OF AUTONOMIC DYSFUNCTION.
  • Place of Presentation: Portland,USA
  • Year and Date: 2016-09-20
  • Int'l Joint Research / Invited
• [Presentation] Detecting subsecond activation changes during interictal epileptic spike using simultaneous EEG-fMRI (2016)
  • Author(s): Bagarinao E, MaesawaS , Ito Y, Watanabe H, Isoda H.
  • Organizer: 22nd Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2016-06-26
  • Int'l Joint Research
• [Presentation] Sequential activation in sub-second range during working memory task: A simultaneous EEG-fMRI study. (2016)
  • Author(s): Mizuno K, Bagarinao E, Maesawa S, Tohira S, Watanabe H, Nakai T, Isoda H.
  • Organizer: 22nd Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Geneva, Switzerland
  • Year and Date: 2016-06-26
  • Int'l Joint Research
• [Presentation] Detecting activation patterns from functional MRI datasets with undermined evene onsets using support vector machines. (2015)
  • Author(s): Bagarinao E, Maesawa S, Watanabe H, Isoda H.
  • Organizer: 45th Annual meeting of the Society for Neuroscience.
  • Place of Presentation: Chicago(USA)
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Book] Technical Considerations for MIBG Cardiac Scintigraphy (2016)
  • Author(s): Watanabe H, Sobue G.
  • Publisher: Clinical Assessment of the Autonomic Nervous System Springer Japan
• [Book] Findings of MIBG Cardiac Scintigraphy: Dementia with Lewy Bodies and Related Dementia. (2016)
  • Author(s): Watanabe H, Sobue G.
  • Publisher: Clinical Assessment of the Autonomic Nervous System Springer Japan