Induction of concentric demyelinating lesion in glia-specific connesin conditional deficient mice.
| Project/Area Number |
15K15341
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
Kira Jun-ichi 九州大学, 医学研究院, 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
山口 浩雄 九州大学, 大学病院, 講師 (00701830)
渡邉 充 九州大学, 大学病院, 医員 (30748009)
真崎 勝久 九州大学, 医学研究院, 助教 (90612903)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 多発性硬化症 / コネキシン / ミクログリア / アストログリア / オリゴデンドログリア / 視神経脊髄炎 |
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| Outline of Final Research Achievements |
We previously published paper about the relationship between early loss of connexin and the mechanisms of multiple sclerosis. Thus we wanted to analyze how connexin loss affect to the pathology of MS. The animal model of inducible conditional connexins(Cx43 and 47) knockout mice were successfully developed and used for the analysis. We induced EAE on these mice and found significant differences between these cKO mice and WT controls. These data clearly indicated the importance of connexins as new therapeutic targets.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Japan Multiple Sclerosis Genetics Consortium Copy Number Variations in Multiple Sclerosis and Neuromyelitis Optica.2015
Author(s)
S. Sato, K. Yamamoto, T. Matsushita, N. Isobe, Y. Kawano, K, Iinuma, M. Niino, T. Fukazawa, Y. Nakamura, M. Watanabe, T. Yonekawa, K. Masaki, S. Yoshimura, H. Murai, R. Yamasaki, J. Kira
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Journal Title
Annals of Neurology
Volume: 78
Issue: 5
Pages: 762-774
DOI
Related Report
Peer Reviewed
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