| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
|---|
| Outline of Final Research Achievements |
Unmyelinated fibers in central nervous systems(CNS) are not well known. Recently, we found Nav 1.2 localizes on the axons of unmyelinated fibers diffusely, not as concentrated localization in the Ranvier nodes on myelinated fibers. Based on this property, we investigated the localization of unmyelinated fibers in the CNS of mice. We found Nav 1.2 diffuse localization on the axons of mossy fibers in hippocampus, parallel fibers in cerebellum, and projection fibers of striatum which are already know to be unmyelinated. In addition to those fibers, we found diffuse localization of Nav 1.2 on the axons in stria terminals and some part of corpus callosum, We also found unmyelinated fibers by electron microscopy. The results suggest, there are still unknown or uninvestigated unmyeilated fibers in CNS.
|
