| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Generation of brown-like fat cells that express UCP1--the critical protein that mediates energy dissipation in the form of heat--is observed in white adipose tissue of mice under a cold challenge or stimulation by an adrenergic agent. Browning potential of white adipose tissue and susceptibility for obesity are both known to be regulated by genetic factors. In this study, we conducted integrated genetic, epigenetic and gene transcriptional analyses on the browning of inbred mouse strains with different potential for browning.
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