The Interplay between genome and epigenome in the browning of white fat cells and obesity
| Project/Area Number |
15K15346
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Waki Hironori 東京大学, 医学部附属病院, 特任准教授 (00466765)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ゲノム / エピゲノム / オープンクロマチン / エンハンサー / SNP / 糖尿病 / 発生・分化 / 細胞・組織 / 遺伝子 |
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| Outline of Final Research Achievements |
Generation of brown-like fat cells that express UCP1--the critical protein that mediates energy dissipation in the form of heat--is observed in white adipose tissue of mice under a cold challenge or stimulation by an adrenergic agent. Browning potential of white adipose tissue and susceptibility for obesity are both known to be regulated by genetic factors. In this study, we conducted integrated genetic, epigenetic and gene transcriptional analyses on the browning of inbred mouse strains with different potential for browning.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] NFIA determines the cis-effect of genetic variation on Ucp1 expression in murine thermogenic adipocytes2022
Author(s)
Hiraike Y, Tsutsumi S, Wada T, Oguchi M, Saito K, Nakamura M, Ota S, Koebis M, Nakao H, Aiba A, Nagano G, Ohno H, Oki K, Yoneda M, Kadowaki T, Aburatani H, Waki H, Yamauchi T.
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Journal Title
iScience
Volume: 25
Issue: 8
Pages: 104729-104729
DOI
Related Report
Peer Reviewed / Open Access
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