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Signaling and Browning in White Adipose Tissues by the Receptors for Short-Chain Fatty Acids

Research Project

Project/Area Number 15K15348
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionKumamoto University

Principal Investigator

Araki Eiichi  熊本大学, 大学院生命科学研究部(医), 教授 (10253733)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsブラウニング / 短鎖脂肪酸 / 肥満 / 内臓脂肪 / 皮下脂肪 / GPR43 / browning
Outline of Final Research Achievements

The induction of beige adipogenesis within white adipose tissue (WAT), known as “browning”, has received attention as a novel anti-obesity strategy. Although acetate could exhibit anti-obesity effect and induce browning of WAT in obese diabetic KK-Ay mice, the contribution of GRP43, a receptor for acetate, on acetate-induced browning, was unknown.
In the present study, it was investigated whether orally administered acetate or butyrate could induce anti-obese effects, genes involved in browning, and browning of WAT in either high fat diet-fed GRP43-deficient or the control mice. In addition, the effects of acetate or butyrate on gene expression were investigated in primary-cultured adipocytes derived from WAT of GRP43-deficient or the control mice.
Treatment with acetate or butyrate induced anti-obesity effect and browning of WAT in both high fat diet-fed mice and upregulated genes involved in browning in either adipocytes, suggesting the GRP43-independent mechanisms.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 9 results,  Acknowledgement Compliant: 6 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Identification of microRNA that represses IRS-1 expression in liver.2018

    • Author(s)
      Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
    • Journal Title

      PLoS One

      Volume: 13 Issue: 1 Pages: 0191553-0191553

    • DOI

      10.1371/journal.pone.0191553

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis.2018

    • Author(s)
      Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 印刷中 Issue: 5 Pages: 994-1006

    • DOI

      10.1161/atvbaha.117.310320

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells.2017

    • Author(s)
      Kajihara N, Kukidome D, Sada K, Motoshima H, Furukawa N, Matsumura T, Nishikawa T, Araki E.
    • Journal Title

      J Diabetes Investig.

      Volume: 印刷中 Issue: 6 Pages: 750-761

    • DOI

      10.1111/jdi.12678

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] New glysemic targets for patients with diabetes from the Japan Diabetes Society2017

    • Author(s)
      Araki E, Haneda M, Kasuga M, Nishikawa T, Kondo T, Ueki K, Kadowaki T
    • Journal Title

      J Diabetes Investig

      Volume: 8 Issue: 1 Pages: 123-125

    • DOI

      10.1111/jdi.12600

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice2016

    • Author(s)
      Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E
    • Journal Title

      J Clin Biochem Nutr

      Volume: 59 Pages: 207-214

    • NAID

      130005268723

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.2016

    • Author(s)
      Sada K, Nishikawa T, Kukidome D, Yoshinaga T, Kajihara N, Sonoda K, Senokuchi1 T, Motoshima H, Matsumura T, Araki E
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 7 Pages: e0158619-e0158619

    • DOI

      10.1371/journal.pone.0158619

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cellular stress response pathways and diabetes mellitus.2015

    • Author(s)
      Araki E, Kondo T, Kai H
    • Journal Title

      Diabetol Int

      Volume: 6 Pages: 239-242

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Measurement of small fibre pain threshold values for the early detection of diabetic polyneuropathy.2015

    • Author(s)
      Kukidome D, Nishikawa T, Sato M, Igata M, Kawashima J, Shimoda S, Matsui K, Obayashi K, Ando Y, Araki E
    • Journal Title

      Diabetic Medicine

      Volume: 33 Pages: 62-69

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Long-term treatment with empagliflozin as add-on to oral anti-diabetes therapy in Japanese patients with type 2 diabetes mellitus.2015

    • Author(s)
      Araki E, Tanizawa Y, Tanaka Y, Taniguchi A, Koiwai K, Kim G, Salsali A, Woerle H.J, Broed U.C
    • Journal Title

      Diabetes Obesity & Metabolism

      Volume: 17 Issue: 7 Pages: 665-674

    • DOI

      10.1111/dom.12464

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] The Metabolic Roles of Heat Shock Protein 72 in Mice Model of Type 2 Diabetes.2017

    • Author(s)
      Kondo T, Kitano S, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, ArakiE
    • Organizer
      The 77th ADA scientific meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The anti diabetic role of heat shock protein 72 in mice model of type 2 diabetes.2017

    • Author(s)
      Kondo T, Kitano S, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, ArakiE
    • Organizer
      The 53th EASD Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Obesity-induced microRNA-222 impairs insulin signaling through the repression of IRS-1 expression in hepatocytes.2017

    • Author(s)
      Ono K, Igata M, Kondo T, Kitano S, Takaki Yuki, Hanatani S, Goto R, enokuchi T, Kawashima J, Furukawa N, Motoshima H, ArakiE
    • Organizer
      The 53th EASD Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of Heat Shock Response Provided by Mild Electrical Stimulation with Heat Shock Improves Metabolic Abnormalities in Obese Subjects with Type 2 Diabetes2016

    • Author(s)
      Kondo T, Goto R, Ono K, Kitano S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
    • Organizer
      52th EASD Annual Meeting
    • Place of Presentation
      Messe Munchen, Munich, Germany
    • Year and Date
      2016-09-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病の成因・病態の分子生物学的解析と新規糖尿病治療法への応用2016

    • Author(s)
      荒木栄一
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都国際会議場、京都市
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] インスリン抵抗性および動脈硬化症発症・進展におけるマクロファージ増殖の意義の検討.2015

    • Author(s)
      瀬ノ口隆文, 山田沙梨恵, 松村剛, 本島寛之, 石井規夫, 福田一起, 村上彩子, 守田雄太郎, 西川武志, 荒木栄一
    • Organizer
      第53回日本糖尿病学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 熊本における食環境整備ブルーサークルメニュー開発の新たな展開―社員食堂版の開発―.2015

    • Author(s)
      本島寛之, 柿村葉子, 三浦幸輔, 毛井順子, 村岡まき子, 久木留大介, 三島裕子, 前中あおい, 長瀬博美, 宮田真理子, 川島隆文, 後藤理英子, 吉村沢子, 福田伴美, 猪原淑子, 関上泰二, 白坂亜子, 岸川秀樹, 下田誠也, 荒木栄一
    • Organizer
      第53回日本糖尿病学会九州地方会
    • Place of Presentation
      福岡
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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