| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The induction of beige adipogenesis within white adipose tissue (WAT), known as “browning”, has received attention as a novel anti-obesity strategy. Although acetate could exhibit anti-obesity effect and induce browning of WAT in obese diabetic KK-Ay mice, the contribution of GRP43, a receptor for acetate, on acetate-induced browning, was unknown.
In the present study, it was investigated whether orally administered acetate or butyrate could induce anti-obese effects, genes involved in browning, and browning of WAT in either high fat diet-fed GRP43-deficient or the control mice. In addition, the effects of acetate or butyrate on gene expression were investigated in primary-cultured adipocytes derived from WAT of GRP43-deficient or the control mice.
Treatment with acetate or butyrate induced anti-obesity effect and browning of WAT in both high fat diet-fed mice and upregulated genes involved in browning in either adipocytes, suggesting the GRP43-independent mechanisms.
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