Study of muscle AMPK-dependent factors that improve metabolic abnormalities in strepotozocin-induced diabetes
| Project/Area Number |
15K15352
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Shiki 琉球大学, 医学研究科, 特命講師 (40342919)
YOKOTA Shigefumi 生理学研究所, 生体機能調節研究領域, NIPSリサーチフェロー (50725281)
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| Research Collaborator |
SAITO Kumiko 生理学研究所, 技術課, 係長
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | AMPK / streptozotocin / myokine / leptin / ストレプトゾトシン / 1型糖尿病 / Myokine |
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| Outline of Final Research Achievements |
AMP kinase (AMPK) is a metabolic sensor that plays an important role in obesity and diabetes. I found that muscle-specific dominant negative AMPK-epxressing transgenic mice (DN-AMPK Tg mice) suppress metabolic abnormalities in streptozotocin-inducd type 1 diabetes. The study revealed that IL-6, irisin, and leptin are involved in the effects of muscle DN-AMPK on streptozotocin-inducd diabetes.
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Report
(3 results)
Research Products
(22 results)
