Functional analyses of mitochondrial roles in hormone-dependent cancer using new technologies

• Project/Area Number: 15K15353
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: Inoue Satoshi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40251251)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乳癌 / 子宮内膜癌 / ミトコンドリア / エネルギー代謝 / 酸化的リン酸化

Outline of Final Research Achievements

To explore the roles of mitochondria in hormone-dependent cancers, we performed functional analyses of mitochondria-related genes using new technologies in cancer cells and tumors. We also studied translational and clinical relevance of these mitochondrial genes in breast cancer and endometrial cancer. We focused on estrogen-responsive mitochondrial COX7RP protein that was originally identified by our group previously. We revealed the role of COX7RP in tumor metabolism and progression in these cancers in the present study. Then we proposed that COX7RP could be a diagnostic factor and a therapeutic target, using clinicopathological analyses and animal models, respectively.

Research Products

• [Journal Article] A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor. (2017)
  • Author(s): Yamada Y, Takayama KI, Fujimura T, Ashikari D, Obinata D, Takahashi S, Ikeda K, Kakutani S, Urano T, Fukuhara H, Homma Y, Inoue S.
  • Journal Title: Cancer Sci. Volume: 108 Issue: 1 Pages: 32-41
  • DOI: 10.1111/cas.13105
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains. (2017)
  • Author(s): Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
  • Journal Title: PLoS Pathog. Volume: 13 Issue: 12 Pages: e1006162-e1006162
  • DOI: 10.1371/journal.ppat.1006162
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells. (2017)
  • Author(s): Misawa A, Takayama KI, Fujimura T, Homma Y, Suzuki Y, Inoue S
  • Journal Title: Cancer Sci Volume: 108(3) Issue: 3 Pages: 373-379
  • DOI: 10.1111/cas.13151
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer. (2017)
  • Author(s): Obinata D, Takayama K, Takahashi S, Inoue S
  • Journal Title: Cancers Volume: 9(3), Issue: 3 Pages: 22-22
  • DOI: 10.3390/cancers9030022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy. (2016)
  • Author(s): Huang L,Zhang H,Cheng CY,Wen F,Tam POS,Zhao P,Chen H,Li Z,Chen L,Tai Z,Yamashiro K,Deng S,Zhu X,Chen W,Li C,Lu F,Li Y,Cheung CMG,Shi Y,Miyake M,Lin Y,Gong B,Liu X,Sim KS,Yang J,Mori K,Zhang X,Cackett PD,Tsujikawa M,Nishida K,Hao F,Ma S,Lin H,Chen J,Fei P,Lai TYY,Tang S,Laude A,Inoue S,et al.
  • Journal Title: Nat Genet Volume: 48 Issue: 6 Pages: 640-647
  • DOI: 10.1038/ng.3546
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preventive effects of raloxifene treatment on agerelated weight loss in postmenopausal women. (2016)
  • Author(s): Urano T, Shiraki M, Kuroda T, Tanaka S, Uenishi K, Inoue S
  • Journal Title: J Bone Miner Metab Volume: 35(1) Issue: 1 Pages: 108-113
  • DOI: 10.1007/s00774-015-0733-8
  • Peer Reviewed
• [Journal Article] Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth (2016)
  • Author(s): Obinata D, Takayama K, Fujiwara K, Suzuki T, Tsutsumi S, Fukuda N, Nagase H, Fujimura T, Urano T, Homma Y, Aburatani H, Takahashi S and Inoue S.
  • Journal Title: Oncogene Volume: ３５ Issue: 49 Pages: 6350-6358
  • DOI: 10.1038/onc.2016.171
  • Peer Reviewed
• [Journal Article] Androgen-induced lncRNA SOCS2-AS1 promotes cell growth and inhibits apoptosis in prostate cancer cells. (2016)
  • Author(s): Misawa A, Takayama K, Urano T, Inoue S
  • Journal Title: J Biol Chem Volume: 291(34) Issue: 34 Pages: 17861-17880
  • DOI: 10.1074/jbc.m116.718536
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation. (2016)
  • Author(s): Onodera Y, Takagi K, Miki Y, Takayama KI, Shibahara Y, Watanabe M, Ishida T, Inoue S, Sasano H, Suzuki T.
  • Journal Title: Cancer Med. Volume: 5 Issue: 8 Pages: 1973-1982
  • DOI: 10.1002/cam4.736
  • Peer Reviewed / Open Access
• [Journal Article] Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1. (2016)
  • Author(s): Aihara H
  • Journal Title: Mol. Cell. Volume: 64 Issue: 1 Pages: 176-188
  • DOI: 10.1016/j.molcel.2016.09.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population. (2016)
  • Author(s): Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M.
  • Journal Title: Hum Mol Genet. Volume: 25 Pages: 5027-5034
  • DOI: 10.1093/hmg/ddw335
  • Peer Reviewed / Open Access
• [Journal Article] Estrogen modulates exercise endurance along with mitochondrial uncoupling protein 3 downregulation in skeletal muscle of female mice. (2016)
  • Author(s): Nagai S, Ikeda K, Horie-Inoue K, Shiba S, Nagasawa S, Takeda S, Inoue S.
  • Journal Title: Biochem Biophys Res Commun Volume: 480 Issue: 4 Pages: 758-784
  • DOI: 10.1016/j.bbrc.2016.10.129
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor. (2016)
  • Author(s): Yamada Y, Nakagawa T, Sugihara T, Horiuchi T, Yoshizaki U , Fujimura T, Fukuhara H, Urano T, Takayama K, Inoue S,Kume H, Homma Y
  • Journal Title: BMC Cancer Volume: 18,16(1) Issue: 1 Pages: 898-898
  • DOI: 10.1186/s12885-016-2926-5
  • Peer Reviewed / Open Access
• [Journal Article] Androgen regulates Mafb expression through its 3’UTR during mouse urethral masculinization (2016)
  • Author(s): Matsushita S, Suzuki K, OginoY, Hino S, Sato T, Suyama M, Matsumoto T, Omori A, Inoue S, Yamada G
  • Journal Title: Endocrinology Volume: 157 Issue: 2 Pages: 844-857
  • DOI: 10.1210/en.2015-1586
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ABHD2, an androgen target gene, promotes prostate cancer cell proliferation and migration. (2016)
  • Author(s): Obinata D, Takada S, Takayama K, Urano T, Ito A, Ashikari D, Fujiwara K, Yamada Y, Murata T, Kumagai J, Fujimura T, Ikeda K, Horie-Inoue K, Homma Y
  • Journal Title: Eur J Cancer 57 Volume: 57 Pages: 39-49
  • DOI: 10.1016/j.ejca.2016.01.002
  • Peer Reviewed
• [Journal Article] Increased Expression of Tripartite Motif (TRIM) 47 Is a Negative Prognostic Predictor in Human Prostate Cancer. (2016)
  • Author(s): Fujimura T, Inoue S, Urano T, Takayama K, Yamada Y, Ikeda K, Obinata D, Ashikari D, Takahashi S, Homma Y.
  • Journal Title: Clin Genitourin Cancer. Volume: Jan 28 Issue: 4 Pages: 1558-7673
  • DOI: 10.1016/j.clgc.2016.01.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The emerging role of non-coding RNA in prostate 1 cancer progression and its implication on diagnosis and treatment. (2016)
  • Author(s): Takayama K, Inoue S
  • Journal Title: Brief Funct Genomics Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Cyclic Stretch Augments Production of Neutrophil Chemokines, Matrix Metalloproteinases, and Activin A in Human Endometrial Stromal Cells. (2015)
  • Author(s): Izumi G, Koga K, Takamura M, Osuga Y.
  • Journal Title: Am J Reprod Immunol Volume: epub Issue: 6 Pages: 501-506
  • DOI: 10.1111/aji.12359
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A (2015)
  • Author(s): Ikeda K, Horie-Inoue K, Ueno T, Suzuki T, Sato W, Shigekawa T, Osaki A, Saeki T, Berezikov E, Mano H, Inoue S
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 13170-13170
  • DOI: 10.1038/srep13170
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression. (2015)
  • Author(s): Takayama K, Misawa A, Suzuki T, Takagi K, Hayashizaki Y, Fujimura T, Homma Y, Takahashi S, Urano T, Inoue S
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 8219-8219
  • DOI: 10.1038/ncomms9219
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of TRIM22 as a progesterone-responsive gene in Ishikawa endometrial cancer cells. (2015)
  • Author(s): Saito-Kanatani M, Urano T, Hiroi H, Momoeda M, Ito M, Fujii T, Inoue S
  • Journal Title: J Steroid Biochem Mol Biol Volume: 154 Pages: 217-225
  • DOI: 10.1016/j.jsbmb.2015.08.024
  • Peer Reviewed
• [Journal Article] MicroRNA library-based functional screening identified miR-216a as a player in bicalutamide resistance in prostate cancer. (2015)
  • Author(s): Miyazaki T, Ikeda K, Horie-Inoue K, Okamoto K, Inoue S
  • Journal Title: J. Clin. Med. Volume: 4 Issue: 10 Pages: 1853-1865
  • DOI: 10.3390/jcm4101853
  • Peer Reviewed / Open Access
• [Journal Article] Toremifene, a selective estrogen receptor modulator, significantly improved biochemical recurrence in bone metastatic prostate cancer: a randomized controlled phase II a trial. (2015)
  • Author(s): Fujimura T, Takahashi S, Kume H, Urano T, Takayama K, Yamada Y, Suzuki M, Fukuhara H, Nakagawa T, Inoue S, Homma Y.
  • Journal Title: BMC Cancer. Volume: 15 Issue: 1 Pages: 836-836
  • DOI: 10.1186/s12885-015-1871-z
  • Peer Reviewed / Open Access
• [Journal Article] TRIM25 has a dual function in the p53/Mdm2 circuit (2015)
  • Author(s): Zhang P, Selabd S, Hammer S, Solozobova V, Yan H, Barte F, Inoue S, Heinrich T, Wittbrodt J, Loosli F, Davidson G, Blattner C
  • Journal Title: Oncogene Volume: 印刷中 Issue: 46 Pages: 5729-5738
  • DOI: 10.1038/onc.2015.21
  • Peer Reviewed
• [Journal Article] Estrogen exhibits a biphasic effect on prostate tumor growth through the ERβ-KLF5 pathway. (2015)
  • Author(s): Nakajima Y, Osakabe A, Waku T, Suzuki T, Akaogi K, Fujimura T, Homma Y, Inoue S, Yanagisawa J
  • Journal Title: Mol Cell Biol Volume: 36 Issue: 1 Pages: 144-156
  • DOI: 10.1128/mcb.00625-15
  • Peer Reviewed
• [Journal Article] Estrogen-related receptors in breast cancer and prostate cancer. (2015)
  • Author(s): Misawa A, Inoue S
  • Journal Title: Front Endocrinol (Lausanne) Volume: 6 Pages: 83-83
  • DOI: 10.3389/fendo.2015.00083
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Identification of growth-modulatory long noncoding RNA that activates estrogen receptor signaling in breast cancer. (2017)
  • Author(s): Inoue S, Horie-Inoue K, Ikeda K
  • Organizer: Keystone Symposia Conference, Noncoding RNAs: From Disease to Targeted Therapeutics
  • Place of Presentation: Fairmont Banff Springs, Banff, Alberta, Canada.
  • Year and Date: 2017-02-05
  • Int'l Joint Research
• [Presentation] アンドロゲン作用プログラムを制御する新しい分子機構の解明；CRPCモデルにおけるアンドロゲンシグナリングの解析 (2017)
  • Author(s): 井上聡
  • Organizer: 第19回UTPシンポジウム[シンポジウム]
  • Place of Presentation: ホテル椿山荘東京（東京都文京区）
  • Year and Date: 2017-01-14
  • Invited
• [Presentation] [研究奨励賞受賞]エストロゲンによって誘導され乳がん細胞の増殖・生存を制御する長鎖非コードRNAの同定 (2017)
  • Author(s): 水戸部悠一、池田和博、堀江公仁子、井上聡
  • Organizer: 第17回関東ホルモンと癌研究会
  • Place of Presentation: ベルサール八重洲（東京都中央区）
• [Presentation] Novel therapeutic strategy for castration-resistant prostate cancer by PI polyamide targeting Oct1. (2017)
  • Author(s): Takayama K, Inoue S
  • Organizer: International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines[Symposium]
  • Place of Presentation: Tokyo, Japan
  • Int'l Joint Research
• [Presentation] shRNAスクリーニングとシーケンス技術によるホルモン不応性がん関連のコード・非コードRNAの同定Functional shRNA library screening and sequencing-based identification of coding and non-coding RNAs that associate with the biology of hormone refractory cancers. (2016)
  • Author(s): 堀江公仁子、池田和博、井上聡
  • Organizer: 第39回日本分子生物学会年会[ワークショップ]
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] アンドロゲン応答性long non-coding RNAとして同定したSOCS2-AS1は前立腺癌におけるアンドロゲンシグナルを促進しアポトーシスを抑制する(SOCS2-AS1, an AR-regulated long non-coding RNA, promotes androgen signals and inhibits apoptosis in prostate cancer) (2016)
  • Author(s): 高山賢一、三沢彩、井上聡
  • Organizer: 第75日本癌学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] ミトコンドリア呼吸鎖複合体の形成促進因子である COX7RP は糖新生を調節する(Mitochondrial supercomplex assembly-stimulating factor, COX7RP regulates gluconeogenesis) (2016)
  • Author(s): 柴祥子、池田和博、堀江公仁子、中山哲俊、田中知明、井上聡
  • Organizer: 第89日本生化学会大会
  • Place of Presentation: 仙台国際センター(宮城県仙台市）
  • Year and Date: 2016-09-25
• [Presentation] Mitochondrial respiratory supercomplex assembly-promoting factor COX7RP regulates bone metabolism in mice. (2016)
  • Author(s): Ikeda K, Shiba S, Horie-Inoue K, Inoue S
  • Organizer: The Joint Annual Meetings of the Endocrine Society of Australia, the Society for Reproductive Biology and the Australian and New Zealand Bone and Mineral Society (ESA/SRB/ANZBMS)
  • Place of Presentation: Gold Coast, Queensland, Australia
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] Female mice lacking estrogen binding fragment associated antigen 9 display decreased bone mineral density. (2016)
  • Author(s): Shiba S, Ikeda K, Azuma K, Sato W, Miyazaki T, Tanaka S, Horie-Inoue K, Inoue S
  • Organizer: The Joint Annual Meetings of the Endocrine Society of Australia, the Society for Reproductive Biology and the Australian and New Zealand Bone and Mineral Society (ESA/SRB/ANZBMS)
  • Place of Presentation: Gold Coast, Queensland, Australia
  • Year and Date: 2016-08-21
  • Int'l Joint Research
• [Presentation] ミトコンドリア超複合体形成と筋肉、褐色脂肪 (2016)
  • Author(s): 井上聡
  • Organizer: 第2回日本筋学会学術集会[特別講演]
  • Place of Presentation: 国立精神・神経医療研究センター(東京都小平市）
  • Year and Date: 2016-08-05
  • Invited
• [Presentation] マウスの運動持続能と骨格筋におけるエストロゲンの役割の解析 (2016)
  • Author(s): 長井咲樹、池田和博、堀江公仁子、竹田省
  • Organizer: 第2回日本筋学会学術集会
  • Place of Presentation: 国立精神・神経医療研究センター(東京都小平市）
  • Year and Date: 2016-08-05
• [Presentation] [優秀演題賞] エクソソームを介してがんの免疫エスケープを引き起こすEBAG9の新しい作用メカニズムと骨における役割 (2016)
  • Author(s): 井上聡、柴祥子、池田和博、宮崎利明、東浩太郎、田中伸哉、堀江公仁子
  • Organizer: 第2回日本骨免疫学会
  • Place of Presentation: ホテルモントレ沖縄スパ＆リゾート（沖縄県国頭郡）
  • Year and Date: 2016-07-06
• [Presentation] アンドロゲン応答性long non-coding RNAとして同定したSOCS2-AS1を介する新たなアポトーシス制御機構の解明 (2016)
  • Author(s): 高山賢一、三沢彩、井上聡
  • Organizer: 日本アンドロロジー学会第35回学術大会
  • Place of Presentation: 群馬県前橋テルサ(群馬県前橋市）
  • Year and Date: 2016-06-24
• [Presentation] 乳癌予後予測因子としてのTRIM44の役割 (2016)
  • Author(s): 川端英孝、池田和博、東浩太郎、杉谷郁子、木脇圭一、藤井丈士、大崎昭彦、佐伯俊昭、堀江公仁子、井上聡
  • Organizer: 第17回ホルモンと癌研究会
  • Place of Presentation: 倉敷アイビースクエア(岡山県倉敷市）
  • Year and Date: 2016-06-24
• [Presentation] [YIA受賞] 前立腺癌におけるp53制御を担う新たなアンドロゲン作用メカニズム (2016)
  • Author(s): 芦苅大作、高山賢一、浦野友彦、高橋悟、井上聡
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2016-04-21
• [Presentation] miRNAによるDNA修飾の変化を介したFOXA1およびアンドロゲン受容体の機能制御 (2016)
  • Author(s): 高山賢一、井上聡
  • Organizer: 第89回日本内分泌学会学術総会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Year and Date: 2016-04-21
• [Presentation] Estrogen-responsive COX7RP that stabilizes mitochondrial respiratory supercomplex assembly regulates tumor growth and metabolism in breast cancer. (2016)
  • Author(s): Inoue S, Ikeda K
  • Organizer: Tenth AACR-JCA Joint Conference“Breakthroughs in Cancer Research: From Biology to Therapeutics”
  • Place of Presentation: Maui, HI, USA
  • Year and Date: 2016-02-16
  • Int'l Joint Research
• [Presentation] [指定講演] 性ホルモン作用プログラムを制御する新しい分子メカニズムとその破綻 (2016)
  • Author(s): 井上聡
  • Organizer: 第16回関東ホルモンと癌研究会
  • Place of Presentation: 東京大学医科学研究所附属病院（東京都港区）
  • Year and Date: 2016-01-30
  • Invited
• [Presentation] エストロゲンは骨格筋におけるエネルギー代謝関連遺伝子の発現を調節し生体での運動持続能を向上させる (2016)
  • Author(s): 池田和博、長井咲樹、堀江公仁子、長澤さや、竹田省、井上聡
  • Organizer: 第24回日本ステロイドホルモン学会
  • Place of Presentation: ホルトホール大分（大分県大分市）
• [Presentation] [JCA-AACR joint symposium] 長鎖ならびに短鎖非コードRNAによるアンドロゲンのがんエピゲノム制御メカニズム（Androgen-mediated long and short non-coding RNA biology that epigenetically regulates tumor growth） (2015)
  • Author(s): 井上聡
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] [シンポジウム] アンドロゲンシグナルの分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略 (2015)
  • Author(s): 井上聡
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] stabilizing factor for mitochondrial respiratory supercomplex assembly facilitates breast tumor growth in hypoxia. (2015)
  • Author(s): Ikeda K, Horie-Inoue K, Inoue S
  • Organizer: EMBO Meeting, Nuclear receptors: From molecules to humans
  • Place of Presentation: Ajaccio, Corsica, France
  • Year and Date: 2015-09-24
  • Int'l Joint Research
• [Presentation] [シンポジウム] アンドロゲン受容体による転写プログラムを制御する新しいエピゲノム作用メカニズム（Novel epigenetic regulatory mechanisms that govern androgen receptor transcriptional program） (2015)
  • Author(s): 井上聡
  • Organizer: 第67回日本細胞生物学会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-06-30
  • Invited
• [Book] Chaprer2; Vitamin K, SXR, and GGCX (pp 21-30) in ”Vitamin K2 - Vital for Health and Wellbeing" (2017)
  • Author(s): Azuma K, Inoue S
  • Total Pages: 326
  • Publisher: InTech
• [Book] Long noncoding RNAs (2015)
  • Author(s): Takayama K, Inoue S
  • Total Pages: 257
  • Publisher: Springer Japan