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Functional analyses of mitochondrial roles in hormone-dependent cancer using new technologies

Research Project

Project/Area Number 15K15353
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Endocrinology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Inoue Satoshi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (40251251)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords乳癌 / 子宮内膜癌 / ミトコンドリア / エネルギー代謝 / 酸化的リン酸化
Outline of Final Research Achievements

To explore the roles of mitochondria in hormone-dependent cancers, we performed functional analyses of mitochondria-related genes using new technologies in cancer cells and tumors. We also studied translational and clinical relevance of these mitochondrial genes in breast cancer and endometrial cancer. We focused on estrogen-responsive mitochondrial COX7RP protein that was originally identified by our group previously. We revealed the role of COX7RP in tumor metabolism and progression in these cancers in the present study. Then we proposed that COX7RP could be a diagnostic factor and a therapeutic target, using clinicopathological analyses and animal models, respectively.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (51 results)

All 2017 2016 2015

All Journal Article (26 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 26 results,  Open Access: 15 results,  Acknowledgement Compliant: 9 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 7 results) Book (2 results)

  • [Journal Article] A novel prognostic factor TRIM44 promotes cell proliferation and migration, and inhibits apoptosis in testicular germ cell tumor.2017

    • Author(s)
      Yamada Y, Takayama KI, Fujimura T, Ashikari D, Obinata D, Takahashi S, Ikeda K, Kakutani S, Urano T, Fukuhara H, Homma Y, Inoue S.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 1 Pages: 32-41

    • DOI

      10.1111/cas.13105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.2017

    • Author(s)
      Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, and Inoue J.
    • Journal Title

      PLoS Pathog.

      Volume: 13 Issue: 12 Pages: e1006162-e1006162

    • DOI

      10.1371/journal.ppat.1006162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.2017

    • Author(s)
      Misawa A, Takayama KI, Fujimura T, Homma Y, Suzuki Y, Inoue S
    • Journal Title

      Cancer Sci

      Volume: 108(3) Issue: 3 Pages: 373-379

    • DOI

      10.1111/cas.13151

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Crosstalk of the Androgen Receptor with Transcriptional Collaborators: Potential Therapeutic Targets for Castration-Resistant Prostate Cancer.2017

    • Author(s)
      Obinata D, Takayama K, Takahashi S, Inoue S
    • Journal Title

      Cancers

      Volume: 9(3), Issue: 3 Pages: 22-22

    • DOI

      10.3390/cancers9030022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.2016

    • Author(s)
      Huang L,Zhang H,Cheng CY,Wen F,Tam POS,Zhao P,Chen H,Li Z,Chen L,Tai Z,Yamashiro K,Deng S,Zhu X,Chen W,Li C,Lu F,Li Y,Cheung CMG,Shi Y,Miyake M,Lin Y,Gong B,Liu X,Sim KS,Yang J,Mori K,Zhang X,Cackett PD,Tsujikawa M,Nishida K,Hao F,Ma S,Lin H,Chen J,Fei P,Lai TYY,Tang S,Laude A,Inoue S,et al.
    • Journal Title

      Nat Genet

      Volume: 48 Issue: 6 Pages: 640-647

    • DOI

      10.1038/ng.3546

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preventive effects of raloxifene treatment on agerelated weight loss in postmenopausal women.2016

    • Author(s)
      Urano T, Shiraki M, Kuroda T, Tanaka S, Uenishi K, Inoue S
    • Journal Title

      J Bone Miner Metab

      Volume: 35(1) Issue: 1 Pages: 108-113

    • DOI

      10.1007/s00774-015-0733-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Oct1 genomic function inhibits androgen receptor signaling and castration-resistant prostate cancer growth2016

    • Author(s)
      Obinata D, Takayama K, Fujiwara K, Suzuki T, Tsutsumi S, Fukuda N, Nagase H, Fujimura T, Urano T, Homma Y, Aburatani H, Takahashi S and Inoue S.
    • Journal Title

      Oncogene

      Volume: 35 Issue: 49 Pages: 6350-6358

    • DOI

      10.1038/onc.2016.171

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Androgen-induced lncRNA SOCS2-AS1 promotes cell growth and inhibits apoptosis in prostate cancer cells.2016

    • Author(s)
      Misawa A, Takayama K, Urano T, Inoue S
    • Journal Title

      J Biol Chem

      Volume: 291(34) Issue: 34 Pages: 17861-17880

    • DOI

      10.1074/jbc.m116.718536

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TACC2 (transforming acidic coiled-coil protein 2) in breast carcinoma as a potent prognostic predictor associated with cell proliferation.2016

    • Author(s)
      Onodera Y, Takagi K, Miki Y, Takayama KI, Shibahara Y, Watanabe M, Ishida T, Inoue S, Sasano H, Suzuki T.
    • Journal Title

      Cancer Med.

      Volume: 5 Issue: 8 Pages: 1973-1982

    • DOI

      10.1002/cam4.736

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.2016

    • Author(s)
      Aihara H
    • Journal Title

      Mol. Cell.

      Volume: 64 Issue: 1 Pages: 176-188

    • DOI

      10.1016/j.molcel.2016.09.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.2016

    • Author(s)
      Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M.
    • Journal Title

      Hum Mol Genet.

      Volume: 25 Pages: 5027-5034

    • DOI

      10.1093/hmg/ddw335

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Estrogen modulates exercise endurance along with mitochondrial uncoupling protein 3 downregulation in skeletal muscle of female mice.2016

    • Author(s)
      Nagai S, Ikeda K, Horie-Inoue K, Shiba S, Nagasawa S, Takeda S, Inoue S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 480 Issue: 4 Pages: 758-784

    • DOI

      10.1016/j.bbrc.2016.10.129

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prognostic value of CD66b positive tumor-infiltrating neutrophils in testicular germ cell tumor2016

    • Author(s)
      Yamada Y, Nakagawa T, Sugihara T, Horiuchi T, Yoshizaki U , Fujimura T, Fukuhara H, Urano T, Takayama K, Inoue S,Kume H, Homma Y
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 898-898

    • DOI

      10.1186/s12885-016-2926-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Androgen regulates Mafb expression through its 3’UTR during mouse urethral masculinization2016

    • Author(s)
      Matsushita S, Suzuki K, OginoY, Hino S, Sato T, Suyama M, Matsumoto T, Omori A, Inoue S, Yamada G
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 2 Pages: 844-857

    • DOI

      10.1210/en.2015-1586

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ABHD2, an androgen target gene, promotes prostate cancer cell proliferation and migration.2016

    • Author(s)
      Obinata D, Takada S, Takayama K, Urano T, Ito A, Ashikari D, Fujiwara K, Yamada Y, Murata T, Kumagai J, Fujimura T, Ikeda K, Horie-Inoue K, Homma Y
    • Journal Title

      Eur J Cancer 57

      Volume: 57 Pages: 39-49

    • DOI

      10.1016/j.ejca.2016.01.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased Expression of Tripartite Motif (TRIM) 47 Is a Negative Prognostic Predictor in Human Prostate Cancer.2016

    • Author(s)
      Fujimura T, Inoue S, Urano T, Takayama K, Yamada Y, Ikeda K, Obinata D, Ashikari D, Takahashi S, Homma Y.
    • Journal Title

      Clin Genitourin Cancer.

      Volume: Jan 28 Issue: 4 Pages: 1558-7673

    • DOI

      10.1016/j.clgc.2016.01.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The emerging role of non-coding RNA in prostate 1 cancer progression and its implication on diagnosis and treatment.2016

    • Author(s)
      Takayama K, Inoue S
    • Journal Title

      Brief Funct Genomics

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cyclic Stretch Augments Production of Neutrophil Chemokines, Matrix Metalloproteinases, and Activin A in Human Endometrial Stromal Cells.2015

    • Author(s)
      Izumi G, Koga K, Takamura M, Osuga Y.
    • Journal Title

      Am J Reprod Immunol

      Volume: epub Issue: 6 Pages: 501-506

    • DOI

      10.1111/aji.12359

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A2015

    • Author(s)
      Ikeda K, Horie-Inoue K, Ueno T, Suzuki T, Sato W, Shigekawa T, Osaki A, Saeki T, Berezikov E, Mano H, Inoue S
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 13170-13170

    • DOI

      10.1038/srep13170

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression.2015

    • Author(s)
      Takayama K, Misawa A, Suzuki T, Takagi K, Hayashizaki Y, Fujimura T, Homma Y, Takahashi S, Urano T, Inoue S
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 8219-8219

    • DOI

      10.1038/ncomms9219

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of TRIM22 as a progesterone-responsive gene in Ishikawa endometrial cancer cells.2015

    • Author(s)
      Saito-Kanatani M, Urano T, Hiroi H, Momoeda M, Ito M, Fujii T, Inoue S
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: 154 Pages: 217-225

    • DOI

      10.1016/j.jsbmb.2015.08.024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microrna library-based functional screening identified androgen-sensitive miR-216a as a player in bicalutamide resistance in prostate cancer2015

    • Author(s)
      Miyazaki T, Ikeda K, Horie-Inoue K, Okamoto K, Inoue S
    • Journal Title

      J. Clin. Med.

      Volume: 4 Issue: 10 Pages: 1853

    • DOI

      10.3390/jcm4101853

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Toremifene, a selective estrogen receptor modulator, significantly improved biochemical recurrence in bone metastatic prostate cancer: A randomized controlled phase II a trial2015

    • Author(s)
      Fujimura T, Takahashi S, Kume H, Urano T, Takayama K, Yamada Y, Suzuki M, Fukuhara H, Nakagawa T, Inoue S, Homma Y.
    • Journal Title

      BMC Cancer.

      Volume: 15 Issue: 1 Pages: 836-836

    • DOI

      10.1186/s12885-015-1871-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRIM25 has a dual function in the p53/Mdm2 circuit2015

    • Author(s)
      Zhang P, Selabd S, Hammer S, Solozobova V, Yan H, Barte F, Inoue S, Heinrich T, Wittbrodt J, Loosli F, Davidson G, Blattner C
    • Journal Title

      Oncogene

      Volume: 印刷中 Issue: 46 Pages: 5729-5738

    • DOI

      10.1038/onc.2015.21

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogen exhibits a biphasic effect on prostate tumor growth through the ERβ-KLF5 pathway.2015

    • Author(s)
      Nakajima Y, Osakabe A, Waku T, Suzuki T, Akaogi K, Fujimura T, Homma Y, Inoue S, Yanagisawa J
    • Journal Title

      Mol Cell Biol

      Volume: 36 Issue: 1 Pages: 144-156

    • DOI

      10.1128/mcb.00625-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogen-related receptors in breast cancer and prostate cancer.2015

    • Author(s)
      Misawa A, Inoue S
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 6 Pages: 83-83

    • DOI

      10.3389/fendo.2015.00083

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Identification of growth-modulatory long noncoding RNA that activates estrogen receptor signaling in breast cancer.2017

    • Author(s)
      Inoue S, Horie-Inoue K, Ikeda K
    • Organizer
      Keystone Symposia Conference, Noncoding RNAs: From Disease to Targeted Therapeutics
    • Place of Presentation
      Fairmont Banff Springs, Banff, Alberta, Canada.
    • Year and Date
      2017-02-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アンドロゲン作用プログラムを制御する新しい分子機構の解明;CRPCモデルにおけるアンドロゲンシグナリングの解析2017

    • Author(s)
      井上聡
    • Organizer
      第19回UTPシンポジウム[シンポジウム]
    • Place of Presentation
      ホテル椿山荘東京(東京都文京区)
    • Year and Date
      2017-01-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] [研究奨励賞受賞]エストロゲンによって誘導され乳がん細胞の増殖・生存を制御する長鎖非コードRNAの同定2017

    • Author(s)
      水戸部悠一、池田和博、堀江公仁子、井上聡
    • Organizer
      第17回関東ホルモンと癌研究会
    • Place of Presentation
      ベルサール八重洲(東京都中央区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Novel therapeutic strategy for castration-resistant prostate cancer by PI polyamide targeting Oct1.2017

    • Author(s)
      Takayama K, Inoue S
    • Organizer
      International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines[Symposium]
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] shRNAスクリーニングとシーケンス技術によるホルモン不応性がん関連のコード・非コードRNAの同定Functional shRNA library screening and sequencing-based identification of coding and non-coding RNAs that associate with the biology of hormone refractory cancers.2016

    • Author(s)
      堀江公仁子、池田和博、井上聡
    • Organizer
      第39回日本分子生物学会年会[ワークショップ]
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] アンドロゲン応答性long non-coding RNAとして同定したSOCS2-AS1は前立腺癌におけるアンドロゲンシグナルを促進しアポトーシスを抑制する(SOCS2-AS1, an AR-regulated long non-coding RNA, promotes androgen signals and inhibits apoptosis in prostate cancer)2016

    • Author(s)
      高山賢一、三沢彩、井上聡
    • Organizer
      第75日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリア呼吸鎖複合体の形成促進因子である COX7RP は糖新生を調節する(Mitochondrial supercomplex assembly-stimulating factor, COX7RP regulates gluconeogenesis)2016

    • Author(s)
      柴祥子、池田和博、堀江公仁子、中山哲俊、田中知明、井上聡
    • Organizer
      第89日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mitochondrial respiratory supercomplex assembly-promoting factor COX7RP regulates bone metabolism in mice.2016

    • Author(s)
      Ikeda K, Shiba S, Horie-Inoue K, Inoue S
    • Organizer
      The Joint Annual Meetings of the Endocrine Society of Australia, the Society for Reproductive Biology and the Australian and New Zealand Bone and Mineral Society (ESA/SRB/ANZBMS)
    • Place of Presentation
      Gold Coast, Queensland, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Female mice lacking estrogen binding fragment associated antigen 9 display decreased bone mineral density.2016

    • Author(s)
      Shiba S, Ikeda K, Azuma K, Sato W, Miyazaki T, Tanaka S, Horie-Inoue K, Inoue S
    • Organizer
      The Joint Annual Meetings of the Endocrine Society of Australia, the Society for Reproductive Biology and the Australian and New Zealand Bone and Mineral Society (ESA/SRB/ANZBMS)
    • Place of Presentation
      Gold Coast, Queensland, Australia
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリア超複合体形成と筋肉、褐色脂肪2016

    • Author(s)
      井上聡
    • Organizer
      第2回日本筋学会学術集会[特別講演]
    • Place of Presentation
      国立精神・神経医療研究センター(東京都小平市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] マウスの運動持続能と骨格筋におけるエストロゲンの役割の解析2016

    • Author(s)
      長井咲樹、池田和博、堀江公仁子、竹田省
    • Organizer
      第2回日本筋学会学術集会
    • Place of Presentation
      国立精神・神経医療研究センター(東京都小平市)
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] [優秀演題賞] エクソソームを介してがんの免疫エスケープを引き起こすEBAG9の新しい作用メカニズムと骨における役割2016

    • Author(s)
      井上聡、柴祥子、池田和博、宮崎利明、東浩太郎、田中伸哉、堀江公仁子
    • Organizer
      第2回日本骨免疫学会
    • Place of Presentation
      ホテルモントレ沖縄スパ&リゾート(沖縄県国頭郡)
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] アンドロゲン応答性long non-coding RNAとして同定したSOCS2-AS1を介する新たなアポトーシス制御機構の解明2016

    • Author(s)
      高山賢一、三沢彩、井上聡
    • Organizer
      日本アンドロロジー学会第35回学術大会
    • Place of Presentation
      群馬県前橋テルサ(群馬県前橋市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳癌予後予測因子としてのTRIM44の役割2016

    • Author(s)
      川端英孝、池田和博、東浩太郎、杉谷郁子、木脇圭一、藤井丈士、大崎昭彦、佐伯俊昭、堀江公仁子、井上聡
    • Organizer
      第17回ホルモンと癌研究会
    • Place of Presentation
      倉敷アイビースクエア(岡山県倉敷市)
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] [YIA受賞] 前立腺癌におけるp53制御を担う新たなアンドロゲン作用メカニズム2016

    • Author(s)
      芦苅大作、高山賢一、浦野友彦、高橋悟、井上聡
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] miRNAによるDNA修飾の変化を介したFOXA1およびアンドロゲン受容体の機能制御2016

    • Author(s)
      高山賢一、井上聡
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Estrogen-responsive COX7RP that stabilizes mitochondrial respiratory supercomplex assembly regulates tumor growth and metabolism in breast cancer.2016

    • Author(s)
      Inoue S, Ikeda K
    • Organizer
      Tenth AACR-JCA Joint Conference“Breakthroughs in Cancer Research: From Biology to Therapeutics”
    • Place of Presentation
      Maui, HI, USA
    • Year and Date
      2016-02-16
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] [指定講演] 性ホルモン作用プログラムを制御する新しい分子メカニズムとその破綻2016

    • Author(s)
      井上聡
    • Organizer
      第16回関東ホルモンと癌研究会
    • Place of Presentation
      東京大学医科学研究所附属病院(東京都港区)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] エストロゲンは骨格筋におけるエネルギー代謝関連遺伝子の発現を調節し生体での運動持続能を向上させる2016

    • Author(s)
      池田和博、長井咲樹、堀江公仁子、長澤さや、竹田省、井上聡
    • Organizer
      第24回日本ステロイドホルモン学会
    • Place of Presentation
      ホルトホール大分(大分県大分市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] [JCA-AACR joint symposium] 長鎖ならびに短鎖非コードRNAによるアンドロゲンのがんエピゲノム制御メカニズム(Androgen-mediated long and short non-coding RNA biology that epigenetically regulates tumor growth)2015

    • Author(s)
      井上聡
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] [シンポジウム] アンドロゲンシグナルの分子メカニズムと去勢抵抗性前立腺癌に対する治療戦略2015

    • Author(s)
      井上聡
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] stabilizing factor for mitochondrial respiratory supercomplex assembly facilitates breast tumor growth in hypoxia.2015

    • Author(s)
      Ikeda K, Horie-Inoue K, Inoue S
    • Organizer
      EMBO Meeting, Nuclear receptors: From molecules to humans
    • Place of Presentation
      Ajaccio, Corsica, France
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] [シンポジウム] アンドロゲン受容体による転写プログラムを制御する新しいエピゲノム作用メカニズム(Novel epigenetic regulatory mechanisms that govern androgen receptor transcriptional program)2015

    • Author(s)
      井上聡
    • Organizer
      第67回日本細胞生物学会
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Chaprer2; Vitamin K, SXR, and GGCX (pp 21-30) in ”Vitamin K2 - Vital for Health and Wellbeing"2017

    • Author(s)
      Azuma K, Inoue S
    • Total Pages
      326
    • Publisher
      InTech
    • Related Report
      2016 Annual Research Report
  • [Book] Long noncoding RNAs2015

    • Author(s)
      Takayama K, Inoue S
    • Total Pages
      257
    • Publisher
      Springer Japan
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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