Role of Pref-1 in the ovary as a novel infertility factor
Project/Area Number |
15K15355
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Endocrinology
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Research Institution | University of Fukui |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | 卵巣 / Pref-1 / ステロイドホルモン |
Outline of Final Research Achievements |
Previously we found Pref-1 as a novel target gene of SF-1. In this study, we examined expression pattern of Pref-1 in the ovary by using gene expression and immunohistochemistry. The expression pattern of Pref-1 was very similar to those of steroidogenesis related genes such as StAR and CYP11A1, suggesting that Pref-1 works as a member of ovarian steroidogenesis or folliculogenesis. Pref-1 is known as a factor involved in the differentiation of adiposite. In this study, we identified, for the first time, that Pref-1 is also a member of steroidogenesis in the ovary and is involved in follicular development.
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Report
(2 results)
Research Products
(12 results)
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[Journal Article] Transcriptional regulation of genes related to progesterone production [Review]2015
Author(s)
Mizutani, T., Ishikane, S., Kawabe, S., Umezawa, A., Miyamoto, K.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 9
Pages: 757-763
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex2015
Author(s)
Mizutani, T., Kawabe, S., Ishikane, S., Imamichi, Y., Umezawa, A., Miyamoto, K.
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Journal Title
Molecular and Cellular Endocrinology
Volume: 408
Pages: 133-137
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials.2015
Author(s)
Kawabe, S., Mizutani, T., Ishikane, S., Martines, ME., Kiyono, Y., Miura, K., Hosoda, H., Imamichi, Y., Kangawa, K., Miyamoto, K., Yoshida Y.
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Journal Title
Cancer Letters
Volume: 366
Issue: 2
Pages: 182-190
DOI
Related Report
Peer Reviewed
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[Presentation] 心房性ナトリウム利尿ペプチドのアンジオテンシンII誘発メラノーマ肺転移増悪に対する抑制作用2015
Author(s)
石兼 真, 水谷哲也, 細田洋司, 徳留 健, 野尻 崇, 三浦浩一, 木村 亨, 河邉真也, 今道力敬, 宮里幹也, 寒川賢治, 宮本 薫
Organizer
第88回日本内分泌学会学術総会
Place of Presentation
東京
Year and Date
2015-04-23
Related Report
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