Role of Pref-1 in the ovary as a novel infertility factor

• Project/Area Number: 15K15355
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: University of Fukui
• Principal Investigator: Miyamoto Kaoru 福井大学, 医学部, 教授 (30125877)
• Project Period (FY): 2015-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 卵巣 / Pref-1 / ステロイドホルモン

Outline of Final Research Achievements

Previously we found Pref-1 as a novel target gene of SF-1. In this study, we examined expression pattern of Pref-1 in the ovary by using gene expression and immunohistochemistry. The expression pattern of Pref-1 was very similar to those of steroidogenesis related genes such as StAR and CYP11A1, suggesting that Pref-1 works as a member of ovarian steroidogenesis or folliculogenesis. Pref-1 is known as a factor involved in the differentiation of adiposite. In this study, we identified, for the first time, that Pref-1 is also a member of steroidogenesis in the ovary and is involved in follicular development.

Research Products

• [Journal Article] Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1. (2015)
  • Author(s): Yazawa T, 他６名
  • Journal Title: Zoological Science Volume: 32 Issue: 4 Pages: 323-330
  • DOI: 10.2108/zs140237
  • NAID: 210000170450
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transcriptional regulation of genes related to progesterone production [Review] (2015)
  • Author(s): Mizutani, T., Ishikane, S., Kawabe, S., Umezawa, A., Miyamoto, K.
  • Journal Title: Endocrine Journal Volume: 62 Issue: 9 Pages: 757-763
  • DOI: 10.1507/endocrj.EJ15-0260
  • NAID: 130005100646
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex (2015)
  • Author(s): Mizutani, T., Kawabe, S., Ishikane, S., Imamichi, Y., Umezawa, A., Miyamoto, K.
  • Journal Title: Molecular and Cellular Endocrinology Volume: 408 Pages: 133-137
  • DOI: 10.1016/j.mce.2014.11.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Establishment and characterization of a novel orthotopic mouse model for human uterine sarcoma with different metastatic potentials. (2015)
  • Author(s): Kawabe, S., Mizutani, T., Ishikane, S., Martines, ME., Kiyono, Y., Miura, K., Hosoda, H., Imamichi, Y., Kangawa, K., Miyamoto, K., Yoshida Y.
  • Journal Title: Cancer Letters Volume: 366 Issue: 2 Pages: 182-190
  • DOI: 10.1016/j.canlet.2015.06.018
  • Peer Reviewed
• [Presentation] ヒト子宮肉腫の高肺転移モデルマウスの確立とその解析 (2015)
  • Author(s): 河邉真也, 水谷哲也, 石兼 真, 吉田好雄, 宮本 薫
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 血管内皮細胞におけるアンジオテンシンⅡシグナルは癌転移を増悪させる (2015)
  • Author(s): 石兼 真, 細田洋司, 野尻 崇, 徳留 健, 水谷哲也, 河邉真也, 今道力敬, 宮本 薫, 宮里幹也, 寒川賢治
  • Organizer: 第33回内分泌代謝学サマーセミナー
  • Place of Presentation: 柳川
  • Year and Date: 2015-07-09
• [Presentation] 心房性ナトリウム利尿ペプチドのアンジオテンシンII誘発メラノーマ肺転移増悪に対する抑制作用 (2015)
  • Author(s): 石兼 真, 水谷哲也, 細田洋司, 徳留 健, 野尻 崇, 三浦浩一, 木村 亨, 河邉真也, 今道力敬, 宮里幹也, 寒川賢治, 宮本 薫
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Presentation] 卵巣におけるCNP分子型の同定とその遺伝子発現調節 (2015)
  • Author(s): 水谷哲也, 河邉真也, 石兼 真, 松村健大, 今道力敬, 南野直人, 宮本 薫
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Presentation] ライディッヒ細胞におけるCox-2発現制御とプロスタグランジン産生 (2015)
  • Author(s): 矢澤隆志, 今道力敬, 宮本 薫, 梅澤明弘, 谷口隆信
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Presentation] ヒトにおける11-ケトテストステロンの合成と役割 (2015)
  • Author(s): 今道力敬, 矢澤隆志, 河邉真也, 石兼 真, 向井邦晃, 折坂 誠, 水谷哲也, 宮本 薫
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Remarks] 分子生体情報学分野-医学科 生命情報医科学講座
  • URL: http://seika2.med.lab.u-fukui.ac.jp/
• [Patent(Industrial Property Rights)] 子宮肉腫と子宮筋腫を鑑別する腫瘍マーカーの開発 (2015)
  • Inventor(s): 水谷哲也、宮本 薫、河邊真也、石兼 真、吉田好雄、福田 真
  • Industrial Property Rights Holder: 水谷哲也、宮本 薫、河邊真也、石兼 真、吉田好雄、福田 真
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-07-31