Identification of a liver-derived factor that regulates proliferation of islet alpha cells
| Project/Area Number |
15K15356
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | グルカゴン / アミノ酸 / ノックアウトマウス / 糖尿病 / 神経内分泌腫瘍 / ランゲルハンス島 / α細胞 / 細胞増殖制御 / グルカゴノーマ / 液性因子 / mTOR |
|---|
| Outline of Final Research Achievements |
Homozygous glucagon-GFP knock-in mice, which is deficient in all the peptide derived from proglucagon, are nomoglycemic and develop hyperplasia of GFP-positive islet alpha-like cells. To elucidate the regulatory mechanisms of alpha cell proliferation, subrenal capsule transplantation experiments were performed, and the result indicated that proliferation of alpha cells is regulated by a humoral factor(s) derived from liver. Although exploration to identify a specific humoral factor failed to identify such factors encoded by a specific gene, accumulating data suggested that hyperaminoacidemia under glucagon deficiency should be involved in accelerated proliferation of islet alpha cells.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Glucose-dependent insulinotropic polypeptide is required for moderate high fat diet, but not high carbohydrate diet-induced weight gain.2018
Author(s)
Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, Hamada Y, Oiso Y, Inagaki N, Arima H, Hayashi Y, Seino Y.
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 6
Issue: 6
Pages: 111-112
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin.2016
Author(s)
Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y.
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Journal Title
Diabetologia
Volume: x
Issue: 7
Pages: 1533-1541
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Chronic hyponatremia causes neurologic and psychologic impairments2016
Author(s)
Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y
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Journal Title
Journal of the American Society of Nephrology
Volume: 27
Issue: 3
Pages: 766-780
DOI
Related Report
Peer Reviewed
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