Crosstalk between GVHD and fungal infection
Project/Area Number |
15K15358
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Hematology
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Research Institution | Hokkaido University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | GVHD / Candida / 肺 / Th17 / Dectin-2 / mannan / 真菌感染 / Mannan / Heat shock protein / 造血幹細胞移植 / 真菌 / カンジダ |
Outline of Final Research Achievements |
We evaluated mechanistic link between graft-versus-host disease (GVHD) and Candida infection after allogeneic hematopoietic stem cell transplantation (SCT) in mouse models. Injection of alpha-Mannan, a major component of fungal cell wall, or heat-killed Candida albicans accelerated lung GVHD. alpha-Mannan induced donor Th17 differentiation and lung specific chemokine environment in GVHD led to Th17 infiltration to the lung. Such effects of alpha-Mannan on GVHD was dependent on both recipient Dectin-2 and donor IL-17A. These results demonstrate a novel mechanistic link between GVHD and Candida infection following allogeneic SCT.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Graft-versus-host disease targets ovary and causes female infertility in mice.2017
Author(s)
S. Shimoji, D. Hashimoto, H. Tsujigiwa, K. Miyawaki, K. Kato, S. Takahashi, R. Ogasawara, T. Jiromaru, H. Iwasaki, T. Miyamoto, K. Akashi, *T. Teshima
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Journal Title
Blood
Volume: 129
Issue: 9
Pages: 1216-1225
DOI
Related Report
Peer Reviewed
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[Journal Article] α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice2015
Author(s)
.Uryu H, Hashimoto D, Kato K, Hayase E, Matsuoka S, Ogasawara R, Takahashi S, Maeda Y, Iwasaki H, Miyamoto T, Saijo S, Iwakura Y, Hill GR, Akashi K, Teshima T
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Journal Title
Blood
Volume: 125
Pages: 3014-3023
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] R-spondin1 promotes Paneth cell growth, maintains intestinal microbial ecology, and ameliorates GVHD2015
Author(s)
Hayase E, Hashimoto D, Nakamura K, Ogura Y, Hayashi T, Kurokawa K, Ayabe T, Teshima T
Organizer
American Society of Hematology
Place of Presentation
Orlando, USA
Year and Date
2015-12-04
Related Report
Int'l Joint Research