| Project/Area Number |
15K15359
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Chiba Shigeru 筑波大学, 医学医療系, 教授 (60212049)
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| Co-Investigator(Renkei-kenkyūsha) |
OBARA Naoshi 筑波大学, 医学医療系, 教授 (70422178)
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| Research Collaborator |
NISHIKII Hidekazu
SAKAMOTO Tatsuhiro
Luan Cao Sy
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨髄ストローマ / 赤芽球 / nestin / NOTCH / Rbpj / 幹細胞ニッチ / Notch / 赤芽球造血 |
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| Outline of Final Research Achievements |
Cells that help blood production in the bone marrow were analyzed using genetically modified mice. It was demonstrated that erythrocyte production in the bone marrow is impaired if a specific signaling (NOTCH signaling) system is turned off in "nestin-expressing cells," one type of non-blood producing cells that are present in the bone marrow at a very low frequency. The mechanism for this observation was analyzed as follows: the abnormality in nestin-expressing bone marrow non-blood producing cells disturbs local environment and increases the secretion of a substance called interleukin 6 from "macrophages," which directly support erythrocyte production in the bone marrow. This causes adverse effect on erythropoietic production.
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