| Project/Area Number |
15K15363
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | かおり / 細胞運命制御 / 嗅覚刺激 / 造血制御 |
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| Outline of Final Research Achievements |
I confirmed mRNA expression of olfactory-specific molecules such as AC3 and Golf in mouse bone marrow, thymus, spleen as well as in cell lines of hematopoietic progenitors and T cells. I also confirmed the protein expression in some of these tissues and cells. G-CSF-induced hematopoietic progenitor mobilization was not altered when an α-pinin was administered together with G-CSF.
We next focused on the in vitro effect of a substance on the cell fate determination in many kinds of cell lines including both hematopoietic and mesenchymal lineage cells, and found that α-pinin can induce apoptosis in T cell line EL-4.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒノキの臭い主成分の一つのα-ピネンは、強く増殖するTリンパ球を抑制し、定常状態にあるT細胞には影響が少ないことから、α-ピネンは免疫抑制剤やT細胞性腫瘍に対する治療薬として有効である可能性があることが示唆された。今後の薬剤デリバリーの観点からも、注射剤などではなくアロマとして病室に漂わせることで補助的治療効果を担う薬剤の開発にも役立つかもしれない。またこれは、森林浴によるヒーリングと言われている現象の一部の説明にもつながるかもしれない。
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