Hematopoietic regulation by five senses: scent

• Project/Area Number: 15K15363
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: KATAYAMA YOSHIO 神戸大学, 医学部附属病院, 講師 (80397885)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: かおり / 細胞運命制御 / 嗅覚刺激 / 造血制御

Outline of Final Research Achievements

I confirmed mRNA expression of olfactory-specific molecules such as AC3 and Golf in mouse bone marrow, thymus, spleen as well as in cell lines of hematopoietic progenitors and T cells. I also confirmed the protein expression in some of these tissues and cells. G-CSF-induced hematopoietic progenitor mobilization was not altered when an α-pinin was administered together with G-CSF.
We next focused on the in vitro effect of a substance on the cell fate determination in many kinds of cell lines including both hematopoietic and mesenchymal lineage cells. I cannot release the information about this part because I have a plan to apply for a patent.