Research Project
Grant-in-Aid for Challenging Exploratory Research
In previous study, it has been shown that the tumor derived exosome, a kind of extracellular vesicle, critically works for development of EBV+ lymphoproliferative diseases (LPD). Thereafter, in order to evaluate the efficacy of the depletion of exosome in these diseases, we tested whether the dilution of the tumor derived exosome effect on the tumor development by use of "parabiosis". As a results, the pair of mouse with and without caner, unexpectedly died just a week after parabiosis, while that of mice with cancer and that of mice without caner survived much longer than that. The mechanistic analysis of the result will be studied.
All 2017 2016 2015 Other
All Journal Article (3 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 3 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 3 results, Invited: 7 results) Book (2 results) Remarks (2 results)
JCI Insight
Volume: 1(8) Issue: 8
10.1172/jci.insight.86646
Scientific Reports
Volume: 12 Issue: 1 Pages: 10294-10294
10.1038/srep19204
Rinsho Ketsueki
Volume: 57 Issue: 1 Pages: 3-8
10.11406/rinketsu.57.3
130005125835
http://kotani.med.u-tokai.ac.jp/
http://inflam.jst.go.jp/research/p_2404kotani/index.html