| Project/Area Number |
15K15370
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kindai University (2016)
Kyoto University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IgG4関連疾患 / 自己免疫性膵炎 / 形質細胞様樹状細胞 / 腸内細菌 |
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| Outline of Final Research Achievements |
We tried to elucidate innate immune responses involved in the development of IgG4-related autoimmune pancreatitis (AIP). To this end, we utilized samples obtained from murine experimental models of AIP and human IgG4-related AIP. In both human and animal studies, we found that AIP-related innate immune responses are characterized by activation of plasmacytoid dendritic cells (pDCs). The development of AIP depends upon both IFN-alpha and IL-33 produced by pDCs. Taken together, these data suggest that activation of pDCs upon sensing of intestinal microflora induces IgG4-related AIP through the production of IFN-alpha and IL-33.
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