Development of a periostin detection kit of next generation

• Project/Area Number: 15K15372
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Saga University
• Principal Investigator: Izuhara Kenji 佐賀大学, 医学部, 教授 (00270463)
• Co-Investigator(Kenkyū-buntansha): 太田 昭一郎 佐賀大学, 医学部, 研究講師 (20346886) ; 有馬 和彦 佐賀大学, 医学部, 助手 (60336112) ; 小川 雅弘 佐賀大学, 医学部, 助教 (90599317) ; 南里 康弘 (宮内康弘) 佐賀大学, 医学部, 研究助教 (00382218) ; 布村 聡 佐賀大学, 医学部, 准教授 (70424728)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: アトピー性皮膚炎 / 喘息 / アレルギー学 / バイオマーカー / アレルギー性結膜炎 / ペリオスチン / 涙液 / マトリックスタンパク質 / 間質性肺炎 / 強皮症 / 診断

Outline of Final Research Achievements

Although it is known that periostin is useful as a biomarker for various diseases, it has a problem in the specificity for diseases. This study aimed at constructing a disease-specific periostin detection kit. We first found that periostin exists as both oligomers and monomers in serum. We next found that two monoclonal anti-periostin antibodies, SS19D and SS19A, recognize only monomeric periostin. We, furthermore, found that monomeric periostin is superior in the abilities to diagnose idiopathic pulmonary fibrosis (IPF) and to predict its poor prognosis of lung functions compared to its conventional biomarkers. These results suggest that measurement of monomeric periostin is useful for diagnosis and treatment of IPF patients.

Research Products

• [Journal Article] Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients (2018)
  • Author(s): Tomoko Okawa, Yukie Yamaguchi, et al.
  • Journal Title: Allergology International Volume: 67 Issue: 1 Pages: 124-130
  • DOI: 10.1016/j.alit.2017.06.016
  • NAID: 130006322096
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma (2017)
  • Author(s): Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono Junya, Atsuta R, Izuhara K, Takahashi K, Miyake S
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 302-309
  • DOI: 10.1016/j.alit.2016.07.005
  • NAID: 130005628231
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis (2017)
  • Author(s): Thuwajit Chanitra、Thuwajit Peti、Jamjantra Pranisa、Pairojkul Chawalit、Wongkham Sopit、Bhudhisawasdi Vajarabhongsa、Ono Junya、Ohta Shoichiro、Fujimoto Kiminori、Izuhara Kenji
  • Journal Title: Oncology Letters Volume: 14 Issue: 1 Pages: 623-634
  • DOI: 10.3892/ol.2017.6250
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum periostin as a useful biomarker of comorbid chronic rhinosinusitis in patients with asthma (2017)
  • Author(s): Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuk Fukumitsu e, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, and Akio Niimi
  • Journal Title: Annals of the American Thoracic Society Volume: 印刷中 Issue: 5 Pages: 667-675
  • DOI: 10.1513/annalsats.201609-720oc
  • Peer Reviewed / Open Access
• [Journal Article] Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma (2017)
  • Author(s): Nagasaki T, Matsumoto H, Izuhara K; The KiHAC Respiratory Medicine Group
  • Journal Title: Allergology International Volume: 66 Issue: 3 Pages: 404-410
  • DOI: 10.1016/j.alit.2017.02.003
  • NAID: 130005858799
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of severe asthma with fungal sensitization (2017)
  • Author(s): Masaki Katsunori、Fukunaga Koichi、Asano Koichiro、Betsuyaku Tomoko, et al.
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 119 Issue: 3 Pages: 253-257
  • DOI: 10.1016/j.anai.2017.07.008
  • Peer Reviewed
• [Journal Article] Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN (2017)
  • Author(s): James A.、Janson C.、Malinovschi A.、Holweg C.、Alving K.、Ono J.、Ohta S.、Ek A.、Middelveld R.、Dahl?n B.、Forsberg B.、Izuhara K.、Dahl?n S.-E.
  • Journal Title: Allergy Volume: 72 Issue: 11 Pages: 1753-1760
  • DOI: 10.1111/all.13181
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Periostin in inflammation and allergy. (2017)
  • Author(s): Izuhara K, Nunomura S, Nanri Y, Ogawa M, Ono J, Mitamura Y, Yoshihara T.
  • Journal Title: Cell Mol Life Sci Volume: 23 Issue: 23 Pages: 4293-4303
  • DOI: 10.1007/s00018-017-2648-0
  • Peer Reviewed / Open Access
• [Journal Article] Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma (2017)
  • Author(s): Mino M, Kanno K, Okimoto K, Sugiyama A, Kishikawa N, Kobayashi T, Ono J, Izuhara K, Kobayashi T, Ohigashi T, Ohdan H, Tazuma S
  • Journal Title: Hepatol Commun Volume: 1 Issue: 10 Pages: 1099-1109
  • DOI: 10.1002/hep4.1114
  • Peer Reviewed / Open Access
• [Journal Article] Subphenotypes of type 2 severe asthma in adults (2017)
  • Author(s): Matsusaka M, Kabata H, Fukunaga K, Izuhara K, Asano K, Betsuyaku T
  • Journal Title: J Allergy Clin Immunol Pract Volume: 6 Issue: 1 Pages: 274-276.e2
  • DOI: 10.1016/j.jaip.2017.06.015
  • Peer Reviewed / Open Access
• [Journal Article] Reduced vitreal concentration of periostin after vitrectomy in patients with proliferative diabetic retinopathy (2016)
  • Author(s): Tachibana T, Yoshida S, Kobayashi Y, Nakama T, Ishikawa K, Nakao S, Izuhara K, Kono T, Ishibashi T
  • Journal Title: Acta Ophthalmologica Volume: 94 Issue: 1
  • DOI: 10.1111/aos.12752
  • Peer Reviewed / Open Access
• [Journal Article] Increased YKL-40 and chitotriosidase in asthma and chronic obstructive pulmonary disease (2016)
  • Author(s): James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 193 Issue: 2 Pages: 131-142
  • DOI: 10.1164/rccm.201504-0760oc
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of periostin in respiratory disorders (2016)
  • Author(s): Izuhara K, Conway SJ, Moore BB, Matsumoto H, Holweg CTJ, Matthews JG, Arron JR
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 193 Issue: 9 Pages: 949-956
  • DOI: 10.1164/rccm.201510-2032pp
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment. (2016)
  • Author(s): Watanabe Y, Yamaguchi Y et al.
  • Journal Title: Br J Dermatol Volume: in press Issue: 6 Pages: 1327-1336
  • DOI: 10.1111/bjd.14426
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria (2016)
  • Author(s): Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, Park GH, Choi JH
  • Journal Title: Allergy, Asthma & Immunology Research Volume: 8 Issue: 5 Pages: 457-460
  • DOI: 10.4168/aair.2016.8.5.457
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multidimensional endotyping in severe asthma reveals inflammatory heterogeneity in MMPs and YKL-40 (2016)
  • Author(s): Hinks T, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanovi; R, Kurukulaaratchy R, Chauhan A, Howarth PH
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 138 Issue: 1 Pages: 61-75
  • DOI: 10.1016/j.jaci.2015.11.020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. (2016)
  • Author(s): Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K.
  • Journal Title: J Allergy Clin Immunol Volume: Epub ahead of print Issue: 2 Pages: 0-0
  • DOI: 10.1016/j.jaci.2015.11.039
  • NAID: 40020962730
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Using periostin as a biomarker in the treatment of asthma (2016)
  • Author(s): Izuhara K, Ohta S, Ono S
  • Journal Title: Allergy, Asthma and Immunology Research Volume: 8 Issue: 6 Pages: 491-498
  • DOI: 10.4168/aair.2016.8.6.491
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Allergen immunotherapy for allergic asthma: protocol for a systematic review (2016)
  • Author(s): Dhami S, Nurmatov U, Agache I, Lau S, Muraro A, Jutel M, Roberts G, Akdis C, Bonini M, Calderon M, Casale T, Cavkaytar O, Cox L, Demoly P, Flood B, Hamelmann E, Izuhara K
  • Journal Title: Clinical and Translational Allergy Volume: 6 Issue: 1 Pages: 5-5
  • DOI: 10.1186/s13601-016-0094-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periostin as a biomarker for diagnosis of pediatric asthma (2016)
  • Author(s): Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, Suzuki R, Sagara N, Yanagida N, Sato S, Ebisawa M, Ohta S, Ono J, Izuhara K, Katunuma T
  • Journal Title: Pediatric Allergy and Immunology Volume: 27 Issue: 5 Pages: 521-526
  • DOI: 10.1111/pai.12575
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. (2016)
  • Author(s): Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ohta S, Ito I, Oguma T, Inoue H, Iwata T, Kanemitsu Y, Nagasaki T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 未定 Issue: 10 Pages: 1472-1479
  • DOI: 10.1111/all.12922
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical implication of the serum periostin level for differentiating phenotypes of NSAID hypersensitivity (2016)
  • Author(s): Kim M, Yoon MK, Lee Y-S, Izuhara K, Ohta S, Ono J, Kim J-H, Ban GY, Ye Y-M, Park H-S
  • Journal Title: Allergology International Volume: 65 Issue: 4 Pages: 492-494
  • DOI: 10.1016/j.alit.2016.04.013
  • NAID: 130005431272
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
  • Journal Title: J Allergy Clin Immunol. Volume: 138 Issue: 5 Pages: 1458
  • DOI: 10.1016/j.jaci.2016.04.047
  • URL: https://pure.teikyo.jp/en/publications/550604d6-0884-4fad-8c75-2eddad633333
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction. (2016)
  • Author(s): Sugiyama A, Kanno K, Nishimichi N, Yokosaki Y, Izuhara K, Ono J, Tazuma S.
  • Journal Title: J Gastroenteroln Volume: in press Issue: 12 Pages: 1161-1174
  • DOI: 10.1007/s00535-016-1206-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Induction of airway allergic inflammation by hypothiocyanite via epithelial cells (2016)
  • Author(s): Suzuki S, Ogawa M, Ohta S, Nunomura S, Nanri Y, Shiraishi H, Mitamura Y, Yoshihara T, James J. Lee, Izuhara K
  • Journal Title: Journal of Biological Chemistry Volume: 291 Issue: 53 Pages: 27219
  • DOI: 10.1074/jbc.m116.746909
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis (2015)
  • Author(s): Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K-i, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K.
  • Journal Title: Allergology International Volume: 64 Issue: 1 Pages: 41-48
  • DOI: 10.1016/j.alit.2014.06.001
  • NAID: 130004873124
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis (2015)
  • Author(s): Tajiri, M., Okamoto, M., Fujimoto, K., Johkoh, T., Ono, J., Tominaga, M., Azuma, K., Kawayama, T., Ohta, S., Izuhara, K. & Hoshino, T.
  • Journal Title: Respiratory investigation Volume: 53 Issue: 2 Pages: 73-81
  • DOI: 10.1016/j.resinv.2014.12.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phenotype of asthma related with high serum periostin levels (2015)
  • Author(s): Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 175-180
  • DOI: 10.1016/j.alit.2014.07.003
  • NAID: 130005290305
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin (2015)
  • Author(s): Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
  • Journal Title: Brit J Ophthalmol Volume: ９９ Issue: 4 Pages: 451-456
  • DOI: 10.1136/bjophthalmol-2014-305321
  • Peer Reviewed / Open Access
• [Journal Article] Periostin in the bronchial lavage fluid of asthma patients (2015)
  • Author(s): akamura, Y., Nagashima, H., Ohta, S., Ono, J., Yamauchi, K. & Izuhara, K.
  • Journal Title: Allergology International Volume: 64 Issue: 2 Pages: 209-210
  • DOI: 10.1016/j.alit.2015.01.001
  • NAID: 130005290284
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] No increase in the serum periostin level is detected in elementary school-age children with allergic diseases (2015)
  • Author(s): Inoue, Y., Izuhara, K., Ohta, S., Ono, J. & Shimojo, N.
  • Journal Title: Allergology International Volume: 64 Issue: 3 Pages: 289-290
  • DOI: 10.1016/j.alit.2015.04.001
  • NAID: 130005290276
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma. (2015)
  • Author(s): Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0129704-e0129704
  • DOI: 10.1371/journal.pone.0129704
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum periostin levels correlate with airway hyperresponsiveness to methacholine and mannitol in children with asthma (2015)
  • Author(s): Song JS, You JS, Jeong SI, Yang S, Hwang IT, Im YG, Baek HS, Kim HY, Izuhara K
  • Journal Title: Allergy Volume: ７０ Issue: 6 Pages: 674-681
  • DOI: 10.1111/all.12599
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent developments regarding periostin in bronchial asthma (2015)
  • Author(s): Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M
  • Journal Title: Allergology International Volume: 64 Issue: Supplement.1 Pages: 3-10
  • DOI: 10.1016/j.alit.2015.04.012
  • NAID: 130005290263
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy (2015)
  • Author(s): Chen C-Y, Lee J-B, Liu B, Ohta S, Wang P-Y, Kartashov A, Mugge L, Abonia JP, Barski A, Izuhara K, Rothenberg ME, Finkelman FD, Hogan SP, Wang Y-S
  • Journal Title: Immunity Volume: ４３ Pages: 788-802
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predicting asthma morbidity in children using proposed markers of Th2-type inflammation (2015)
  • Author(s): Konradsen, J.R., Skantz, E., Nordlund, B., Lidegran, M., James, A., Ono, J., Ohta, S., Izuhara, K., Dahlen, S.E., Alving, K. & Hedlin, G.
  • Journal Title: Pediatric allergy and immunology Volume: 26 Issue: 8 Pages: 772-9
  • DOI: 10.1111/pai.12457
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Chitinase proteins YKL-40 and chitotriosidase are increased in both asthma and COPD (2015)
  • Author(s): James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
  • Journal Title: Am J Respir Crit Care Med Volume: １９３ Issue: 9 Pages: 131-142
  • DOI: 10.1371/journal.pone.0024399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Allergen immunotherapy for allergic asthma: protocol for a systematic review (2015)
  • Author(s): Dhami S, et al.
  • Journal Title: Clin Transl Allergy Volume: ６ Issue: 1 Pages: 12-12
  • DOI: 10.1186/s13601-016-0099-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation. (2014)
  • Author(s): Yoshida S, Kobayashi Y, Nakama T, Zhou Y, Ishikawa K, Arita R,Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T,Ishibashi T
  • Journal Title: Br J Ophthalmol Volume: 99 Issue: 5 Pages: 629-634
  • DOI: 10.1136/bjophthalmol-2014-305860
  • Peer Reviewed / Open Access
• [Presentation] Serum squamous cell carcinoma antigen-2 is a highly sensitive biomarker for atopic dermatitis in children (2018)
  • Author(s): Kawano T, Nagao M, Fujisawa T, Odajima H, Inagaki S, Ohya Y, Azuma Y, Nomura N, Izuhara K
  • Organizer: AAAAI Annual Meeting / World Allergy Congress (WAC) 2018
  • Int'l Joint Research
• [Presentation] An elevated circulating level of periostin in patients with systemic sclerosis: associations with functional impairment in various affected organs (2017)
  • Author(s): Yamaguchi Y, Shirai Y, Ono J, Kawaguchi Y, Izuhara K, Kuwana M, Aihara M
  • Organizer: 76th Society for Investigative Dermatology Annual Meeting
  • Int'l Joint Research
• [Presentation] Three-year follow-up on exacerbation rate in severe (2017)
  • Author(s): Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Suzuki M, Ono J, Ohta S, Izuhara K, Nishimura M
  • Organizer: American Thoracic Society (ATS)2017 International Conference
  • Int'l Joint Research
• [Presentation] Correlation between serum monomeric periostin and the prognosis in patients with acute exacerbation of fibrosing interstitial pneumonia (2017)
  • Author(s): Shimizu H, Sakamoto S, Isshiki T, Urabe N, Suzuki A, Gocho K, Sano G, Sugino K, Isobe K, Takai Y, Okamoto M, Hoshino T, Izuhara K, Homma S
  • Organizer: American Thoracic Society (ATS)2017 International Conference
  • Int'l Joint Research
• [Presentation] Decreased lung function relates to increased type-2 inflammation in asthma subjects from the swedish ga2len study (2017)
  • Author(s): Mogensen I, Alving K, James A, Ono J, Ohta S, Izuhara K, Forsberg B, Dahlen S, Janson C, Malinovschi A
  • Organizer: EAACI Congress 2017
  • Int'l Joint Research
• [Presentation] Clarification of the pathogenesis of allergic diseases and application of the findings to clinical medicine (2017)
  • Author(s): Izuhara K
  • Organizer: 5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR'17)
  • Int'l Joint Research / Invited
• [Presentation] Monitoring the inflammatory heterogeneity in asthma with multiple biomarkers for multidimentional endotyping (2017)
  • Author(s): Agache I, Strasser DS, Pierlot GM, Farine H, Izuhara K, Akdis CA
  • Organizer: European Respiratory Society (ERS) International Congress 2017
  • Int'l Joint Research
• [Presentation] Roles of periostin in patients with severe obstructive sleep apnea (2017)
  • Author(s): Sunadome H, Matsumoto H, Tachikawa R, Matsumoto T, Tanizawa K, Oga T, Izuhara K, Chin K, Ono J, Ohta S
  • Organizer: European Respiratory Society (ERS) International Congress 2017
  • Int'l Joint Research
• [Presentation] Risks for asthma exacerbations in patients with type 2-low endotype (2017)
  • Author(s): Ishiyama Y, Matsumoto H, Sunadome H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Kanemitsu Y, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Izuhara K, Mishima M
  • Organizer: European Respiratory Society (ERS) International Congress 2017
  • Int'l Joint Research
• [Presentation] Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort (2017)
  • Author(s): Jones T, Brown T, Elliott S, Barber C, Gove K, Lau L, Rupani H, Chauhan A, Howarth P, Ono J, Izuhara K
  • Organizer: European Respiratory Society (ERS) International Congress 2017
  • Int'l Joint Research
• [Presentation] Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling (2017)
  • Author(s): Kataoka M, Yamaguchi Y, Koumitsu N, Arima K, Izuhara K, Aihara M
  • Organizer: 47th Annual ESDR Meeting
  • Int'l Joint Research
• [Presentation] Serum tenascin-C levels in patients with asthma (2017)
  • Author(s): Harada N, Asaji M, Harada S, Ishimori A, Katsura Y, Itoigawa Y, Matsuno K, Makino F, Ito J, Ono J, Tobino K, Akiba H, Atsuta R, Izuhara K, Takahashi K
  • Organizer: The Asian Pacific Society of Respirology (APSR) Congress 2017
  • Int'l Joint Research
• [Presentation] 血清ペリオスチン低値喘息群における増悪因子 (2017)
  • Author(s): 石山祐美、松本久子、金光禎寛、東田有智、堀口高彦、北英夫、桑原和伸、富井啓介、大塚浩二郎、藤村政樹、大倉徳幸、富田桂公、横山彰仁、大西広志、中野恭幸、小熊哲也、保澤総一郎、新実彰男、出原裕美、長崎忠雄、小熊毅、田尻智子、伊藤功朗、出原賢治、三嶋理晃
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 重症閉塞性睡眠時無呼吸症候群における血清ペリオスチン値 (2017)
  • Author(s): 砂留広伸、松本久子、立川良、松本健、谷澤公伸、小賀徹、出原賢治、陳和夫
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 新規Periostin ELISAシステムを用いた肺線維症特異的バイオマーカーの探索研究 (2017)
  • Author(s): 岡元政樹、太田昭一郎、小野純也、出原賢治、星野智昭
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 好酸球性肺炎の気管支肺胞洗浄液ではペリオスチン濃度が上昇している (2017)
  • Author(s): 中込一之、中村豊、小林威仁、太田昭一郎、小野純也、野口哲、杣知行、坂本芳雄、山内広平、出原賢治、永田真
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 気管支喘息症例における末消血自然リンパ球 (2017)
  • Author(s): 石森絢子、原田紀宏、原田園子、松野圭、浅地美奈、牧野文彦、伊藤潤、熱田了、千葉麻子、出原賢治、三宅幸子、高橋和久
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] アレルギー性気管支肺アスペルギルス症におけるペリオスチン発現 (2017)
  • Author(s): 田中淳、小熊剛、蛇澤晶、原田一樹、友松克允、松坂雅子、加畑宏樹、福永興壱、別役智子、小野純也、太田昭一郎、出原賢冶、 浅野浩一郎
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] NOGhIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発 (2017)
  • Author(s): 丸岡秀一郎、伊藤亮治、布村聡、権寧博、曽田香織、太田昭一郎、出原賢治、伊藤守、橋本修
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 線維化型間質性肺炎急性憎悪における血清Periostin値と予後の検討 (2017)
  • Author(s): 清水宏繁、坂本晋、一色琢磨、ト部尚久、後町杏子、佐野剛、杉野圭史、磯部和順、高井雄二郎、岡本昌樹、星野友昭、出原賢治、本間栄
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 気道上皮細胞は平滑筋細胞からのペリオスチン産生を亢進させる (2017)
  • Author(s): 知花和行、堀金有紀子、渡邊泰治、 塩原太一、清水泰生、武政聡浩、小野純也、出原賢治、石井芳樹
  • Organizer: 第57回日本呼吸器学会学術講演会
• [Presentation] 癌抗原SCCA-2 は小児アトピー性皮膚炎の優れたバイオマーカーである (2017)
  • Author(s): 竹内聡、古庄憲弘、小野純也、竹村正規、江崎仁一、三田村康貴、 東義則、林純、出原賢治、古江増隆
  • Organizer: 第116回日本皮膚科学会総会
• [Presentation] ペリオスチンによる副鼻腔炎のフェノタイピング (2017)
  • Author(s): 二ノ宮貴裕、野口恵美子、春名威範、長谷川雅世、吉田拓人、山下ゆき子、岡野光博、吉田尚弘、春名眞一、佐久間康徳、太田昭一郎、出原賢治、岡田昌史、徳永貴広、坂下雅文、高林哲司、藤枝重治
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 血清ペリオスチン低値の喘息例における増悪因子の検討 (2017)
  • Author(s): 石山祐美、松本久子、金光禎寛、東田有智、堀口高彦、北英夫、桑原和伸、富井啓介、大塚浩二郎、藤村政樹、大倉徳幸、冨田桂公、横山彰仁、大西広志、中野恭幸、小熊哲也、保澤総一郎、新実彰男、出原賢治、三嶋理晃
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 気道上皮細胞は平滑筋細胞からのペリオスチン発現を亢進させる (2017)
  • Author(s): 塩原太一、知花和行、堀金有紀子、渡邊泰治、清水泰生、武政聡浩、小野純也、出原賢治、石井芳樹
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] Omalizumab投与後も増悪が残る重症喘息例の検討 (2017)
  • Author(s): 森本千絵、田尻智子、松本久子、出原裕美、権寧博、伊藤玲子、橋本修、出原賢治、太田昭一郎、小野純也、鈴川真穂、大田健、金光禎寛、長崎忠雄、小熊毅、伊藤功朗、新実彰男、三嶋理晃
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 好酸球性肺炎の気管支肺胞洗浄液におけるペリオスチン及びサイトカイン濃度の解析 (2017)
  • Author(s): 中込一之、中村豊、小林威仁、太田昭一郎、小野純也、野口哲、杣知行、坂本芳雄、山内広平、出原賢治、永田真
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 非アレルギー児における年齢別血清ペリオスチン値 第2報 (2017)
  • Author(s): 藤谷宏子、太田伸男、藤川詩織、春日彩季、比嘉勇介、新宅治夫、小野純也、出原賢治
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] ペリオスチントランスジェニックマウスにおける創傷治癒の遅延 (2017)
  • Author(s): 布村聡，太田昭一郎、小川雅弘，南里康弘、三田村康貴、吉原智仁、 出原賢治
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] ヒト線維細胞におけるSOX11を介したIL-13依存性のペリオスチン発現の誘導 (2017)
  • Author(s): 三田村康貴、布村聡、小川雅弘、南里康弘、太田昭一郎、吉原智仁、古江増隆、出原賢治
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 小児喘息診断におけるペリオスチンを含むバイオマーカーの組み合わせによる有用性の検討 (2017)
  • Author(s): 相良長俊、井上隆志、青田明子、赤司賢一、小野純也、出原賢治、勝沼俊雄
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 剖検肺にてペリオスチンの集積を認めた家族性間質性肺炎の急性増悪の一例 (2017)
  • Author(s): 村田圭祐、古賀康彦、 蜂巣克昌、笠原礼光、 鶴巻寛朗、矢冨正清、小野昭浩、解良恭一、中島希、松村望、横尾英明、布村 聡、太田昭一郎、出原賢治、小野純也、土橋邦生、久田剛志
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 慢性蕁麻疹（CSU）患者における抗FcεRIα鎖（α鎖）自己抗体の解析(第1報） (2017)
  • Author(s): 伊崎聡志、豊島翔太、西盛信幸、柏倉淳一、布村聡、藤澤大輔、畠田優子、葉山惟大、藤田英樹、羅智靖、照井正、岡山吉道
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 慢性蕁麻疹（CSU）患者におけるIgE自己抗体および抗FcεRIα鎖（α鎖）自己抗体の解析(第2報） (2017)
  • Author(s): 伊崎聡志、豊島翔太、西盛信幸、柏倉淳一、布村聡、藤澤大輔、畠田優子、葉山惟大、藤田英樹、羅智靖、照井正、岡山吉道
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 好酸球性多発血管炎性肉芽腫症のバイオマーカーとしてのペリオスチン (2017)
  • Author(s): 伊藤潤、谷口正実、福富友馬、渡井健太郎、三井千尋、林浩昭、関谷潔史、粒来崇博、小野純也、原田紀宏、熱田了、出原賢治、高橋和久
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] 苦参は好酸球造血及び遊走を阻害することにより好酸球性気道炎症を抑制する (2017)
  • Author(s): 續啓史、有信洋二郎、宮脇恒太、高木綾子、大田俊一郎、植木尚子、大田友里、Tabrizi SJ、三苫弘喜、赤星光輝、新納宏昭、堀内孝彦、太田昭一郎、出原賢治、水口博之、福井裕行、塚本浩、赤司浩一
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] マウス慢性喘息モデルを用いたペリオスチン動態の検討 (2017)
  • Author(s): 田中圭介、布村聡、太田昭一郎、與語健二、間木麻友、出原賢治、松本義弘
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] A novel, automated periostin assay; correlation with a commercial ELISA method and usability as a biomarker for type 2 inflammation (2017)
  • Author(s): Takai M, Ono J, Kamei A, Matsumoto H, Ohta S, Izuhara K
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] Squamous cell carcinoma antigen (SCCA)-2 is a potent biomarker for infantile and preschool child atopic dermatitis in Ishigaki Cohort (2017)
  • Author(s): Takeuchi S, Furusyo N, Ono J, Takemura M, Esaki H, Yamamura K, Mitamura Y, Tsuji G, Oda M, Azuma Y, Hayashi J, Izuhara K, Furue M
  • Organizer: 第66回日本アレルギー学会学術大会
• [Presentation] Elevated periostin concentrations in the bronchoalveolar lavage fluid of eosinophilic pneumonia (2017)
  • Author(s): Nakagome K, Ohta S, Soma T, Izuhara K
  • Organizer: 第46回日本免疫学会総会・学術集会
• [Presentation] The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation (2017)
  • Author(s): Mitamura Y, Nunomura S, Ogawa M, Nanri Y, Yoshihara T, Masuoka M, Tuji G, Nakahara T, Furue M, Izuhara K
  • Organizer: 日本研究皮膚科学会（JSID）第42回年次学術大会・総会
• [Presentation] Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling (2017)
  • Author(s): Kanaoka M, Yamaguchi Y, Komitsu N, Arima K, Izuhara K, Aihara M
  • Organizer: 日本研究皮膚科学会（JSID）第42回年次学術大会・総会
• [Presentation] Integration of periostin and M2 macrophages in human and murine melanoma progression (2017)
  • Author(s): Ohno F, Nakahara T, Nakahara M, Nunomura S, Izuhara K, Furue M
  • Organizer: 日本研究皮膚科学会（JSID）第42回年次学術大会・総会
• [Presentation] Anti-FcεRIα and IgE autoantibodies of the chronic spontaneous urticaria patients may have the ability of crosslinking of FcεRI. (2017)
  • Author(s): Izaki S, Toyoshima S, Nunomura S, Kanegae K, Kashiwakura J, Nakamura R, Sakamoto T, Nishimori N, Endo T, Akiyama H, Hayama K, Ra C, Okayama Y, Terui T
  • Organizer: 日本研究皮膚科学会（JSID）第42回年次学術大会・総会
• [Presentation] アレルギー疾患の治療薬最前線-2型サイトカインの標的薬 (2017)
  • Author(s): 出原賢治
  • Organizer: 第4回総合アレルギー講習会
• [Presentation] A case of Eosinophilic fasciitis immunohistochemically positive for Periostin (2017)
  • Author(s): Mori M, Masuoka M, Nagase K, Inoue T, Izuhara K, Narisawa Y
  • Organizer: 第69回日本皮膚科学会西部支部学術大会
• [Presentation] 新規治療薬のコンパニオン診断 (2016)
  • Author(s): 出原賢治
  • Organizer: 第3回日本アレルギー学会総合アレルギー講習会
  • Place of Presentation: 横浜
  • Year and Date: 2016-12-17
  • Invited
• [Presentation] アレルギー疾患とペリオスチン (2016)
  • Author(s): 出原賢治
  • Organizer: 第65回日本アレルギー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-19
  • Invited
• [Presentation] Allergology Internationalから観た英文論文作製の注意点とコツ (2016)
  • Author(s): 出原賢治
  • Organizer: 第65回日本アレルギー学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] The potential for repositioning anti-thyroid agents as anti-asthma drugs (2016)
  • Author(s): Izuhara K, Suzuki S, Ogawa M, Ohta S, Nanri Y
  • Organizer: 31st Collegium Internationale Allergologicum
  • Place of Presentation: Charleston (USA)
  • Year and Date: 2016-04-06
  • Int'l Joint Research
• [Presentation] アレルギー性炎症の慢性化機序 (2016)
  • Author(s): 出原賢治
  • Organizer: 第34回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 鳥羽
  • Year and Date: 2016-02-04
  • Invited
• [Presentation] 分子標的の探索 (2015)
  • Author(s): 出原賢治
  • Organizer: 第2回日本アレルギー学会総合アレルギー講習会
  • Place of Presentation: 横浜
  • Year and Date: 2015-12-12
  • Invited
• [Presentation] 気管支喘息治療における新時代の幕開け (2015)
  • Author(s): 出原賢治
  • Organizer: 第53回日本内科学会近畿支部生涯教育講演会
  • Place of Presentation: 神戸
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] マトリセルラータンパク質であるペリオスチンによる炎症惹起機序とその臨床応用 (2015)
  • Author(s): 出原賢治
  • Organizer: 第19回日本内分泌病理学会学術総会
  • Place of Presentation: 佐賀
  • Year and Date: 2015-10-24
  • Invited
• [Presentation] Potential protein markers for asthma (2015)
  • Author(s): Izuhara K
  • Organizer: XXIV World Allergy Congress
  • Place of Presentation: Seoul
  • Year and Date: 2015-10-14
  • Int'l Joint Research / Invited
• [Presentation] Recent progress in the basic research of periostin in bronchial asthma (2015)
  • Author(s): 出原賢治
  • Organizer: 第25回国際喘息学会日本・北アジア部会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-03
  • Int'l Joint Research / Invited
• [Presentation] 喘息におけるバイオマーカー レビュートーク (2015)
  • Author(s): 出原賢治
  • Organizer: 第64回日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-26
  • Invited
• [Presentation] 間質性肺炎特異的ペリオスチン測定キットの開発 (2015)
  • Author(s): 出原賢治
  • Organizer: 第55回日本呼吸器学会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-17
  • Invited
• [Book] Evolution of Atopic Dermatitis in the 21st Century: Cytokine Network (2018)
  • Author(s): Izuhara K, Nunomura S, Ohta S, Ogawa M, Nanri Y
  • Total Pages: 381
  • Publisher: Springer Nature Singapore
  • ISBN: 9789811055409
• [Book] The role of pendrin in health and disease: The role of pendrin in the airways: Links with asthma and COPD (2017)
  • Author(s): Izuhara K, Suzuki S, Nofziger C, Ogawa M, Ohta S, Nanri Y, Mitamura Y, Yoshihara T, Pedemonte N, Galietta LJV, Paulmichl M
  • Total Pages: 226
  • Publisher: Springer International Publishing Switzerland
  • ISBN: 9783319432854
• [Book] 内科学 第11版：アレルギーに関与する細胞・分子 (2017)
  • Author(s): 出原賢治
  • Total Pages: 2385
  • Publisher: 朝倉書店
  • ISBN: 9784254322705
• [Book] llergies: Current challenges and solutions (2016)
  • Author(s): Izuhara K, Matsumoto H, Nagasaki T, Ohta S, Ono J, Kinki Hokuriku Airway Disease Conference
  • Total Pages: 239
  • Publisher: Pacini Editore Medicina
• [Book] Annual Review 2015 呼吸器 (2015)
  • Author(s): 出原賢治、有馬和彦、太田昭一郎
  • Total Pages: 252
  • Publisher: 中外医学社
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学ホームページ
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php