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Development of a periostin detection kit of next generation

Research Project

Project/Area Number 15K15372
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionSaga University

Principal Investigator

Izuhara Kenji  佐賀大学, 医学部, 教授 (00270463)

Co-Investigator(Kenkyū-buntansha) 太田 昭一郎  佐賀大学, 医学部, 研究講師 (20346886)
有馬 和彦  佐賀大学, 医学部, 助手 (60336112)
小川 雅弘  佐賀大学, 医学部, 助教 (90599317)
南里 康弘 (宮内康弘)  佐賀大学, 医学部, 研究助教 (00382218)
布村 聡  佐賀大学, 医学部, 准教授 (70424728)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsアトピー性皮膚炎 / 喘息 / アレルギー学 / バイオマーカー / アレルギー性結膜炎 / ペリオスチン / 涙液 / マトリックスタンパク質 / 間質性肺炎 / 強皮症 / 診断
Outline of Final Research Achievements

Although it is known that periostin is useful as a biomarker for various diseases, it has a problem in the specificity for diseases. This study aimed at constructing a disease-specific periostin detection kit. We first found that periostin exists as both oligomers and monomers in serum. We next found that two monoclonal anti-periostin antibodies, SS19D and SS19A, recognize only monomeric periostin. We, furthermore, found that monomeric periostin is superior in the abilities to diagnose idiopathic pulmonary fibrosis (IPF) and to predict its poor prognosis of lung functions compared to its conventional biomarkers. These results suggest that measurement of monomeric periostin is useful for diagnosis and treatment of IPF patients.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (104 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (39 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 39 results,  Open Access: 37 results,  Acknowledgement Compliant: 13 results) Presentation (58 results) (of which Int'l Joint Research: 15 results,  Invited: 12 results) Book (5 results) Remarks (2 results)

  • [Journal Article] Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients2018

    • Author(s)
      Tomoko Okawa, Yukie Yamaguchi, et al.
    • Journal Title

      Allergology International

      Volume: 67 Issue: 1 Pages: 124-130

    • DOI

      10.1016/j.alit.2017.06.016

    • NAID

      130006322096

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma2017

    • Author(s)
      Ishimori A, Harada N, Chiba A, Harada S, Matsuno K, Makino F, Ito J, Ohta S, Ono Junya, Atsuta R, Izuhara K, Takahashi K, Miyake S
    • Journal Title

      Allergology International

      Volume: 66 Issue: 2 Pages: 302-309

    • DOI

      10.1016/j.alit.2016.07.005

    • NAID

      130005628231

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis2017

    • Author(s)
      Thuwajit Chanitra、Thuwajit Peti、Jamjantra Pranisa、Pairojkul Chawalit、Wongkham Sopit、Bhudhisawasdi Vajarabhongsa、Ono Junya、Ohta Shoichiro、Fujimoto Kiminori、Izuhara Kenji
    • Journal Title

      Oncology Letters

      Volume: 14 Issue: 1 Pages: 623-634

    • DOI

      10.3892/ol.2017.6250

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum periostin as a useful biomarker of comorbid chronic rhinosinusitis in patients with asthma2017

    • Author(s)
      Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuk Fukumitsu e, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, and Akio Niimi
    • Journal Title

      Annals of the American Thoracic Society

      Volume: 印刷中 Issue: 5 Pages: 667-675

    • DOI

      10.1513/annalsats.201609-720oc

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of serum periostin in combination with exhaled nitric oxide in the management of asthma2017

    • Author(s)
      Nagasaki T, Matsumoto H, Izuhara K; The KiHAC Respiratory Medicine Group
    • Journal Title

      Allergology International

      Volume: 66 Issue: 3 Pages: 404-410

    • DOI

      10.1016/j.alit.2017.02.003

    • NAID

      130005858799

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of severe asthma with fungal sensitization2017

    • Author(s)
      Masaki Katsunori、Fukunaga Koichi、Asano Koichiro、Betsuyaku Tomoko, et al.
    • Journal Title

      Annals of Allergy, Asthma & Immunology

      Volume: 119 Issue: 3 Pages: 253-257

    • DOI

      10.1016/j.anai.2017.07.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN2017

    • Author(s)
      James A.、Janson C.、Malinovschi A.、Holweg C.、Alving K.、Ono J.、Ohta S.、Ek A.、Middelveld R.、Dahl?n B.、Forsberg B.、Izuhara K.、Dahl?n S.-E.
    • Journal Title

      Allergy

      Volume: 72 Issue: 11 Pages: 1753-1760

    • DOI

      10.1111/all.13181

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Periostin in inflammation and allergy.2017

    • Author(s)
      Izuhara K, Nunomura S, Nanri Y, Ogawa M, Ono J, Mitamura Y, Yoshihara T.
    • Journal Title

      Cell Mol Life Sci

      Volume: 23 Issue: 23 Pages: 4293-4303

    • DOI

      10.1007/s00018-017-2648-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periostin promotes malignant potential by induction of epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma2017

    • Author(s)
      Mino M, Kanno K, Okimoto K, Sugiyama A, Kishikawa N, Kobayashi T, Ono J, Izuhara K, Kobayashi T, Ohigashi T, Ohdan H, Tazuma S
    • Journal Title

      Hepatol Commun

      Volume: 1 Issue: 10 Pages: 1099-1109

    • DOI

      10.1002/hep4.1114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subphenotypes of type 2 severe asthma in adults2017

    • Author(s)
      Matsusaka M, Kabata H, Fukunaga K, Izuhara K, Asano K, Betsuyaku T
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 6 Issue: 1 Pages: 274-276.e2

    • DOI

      10.1016/j.jaip.2017.06.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced vitreal concentration of periostin after vitrectomy in patients with proliferative diabetic retinopathy2016

    • Author(s)
      Tachibana T, Yoshida S, Kobayashi Y, Nakama T, Ishikawa K, Nakao S, Izuhara K, Kono T, Ishibashi T
    • Journal Title

      Acta Ophthalmologica

      Volume: 94 Issue: 1

    • DOI

      10.1111/aos.12752

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased YKL-40 and chitotriosidase in asthma and chronic obstructive pulmonary disease2016

    • Author(s)
      James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 193 Issue: 2 Pages: 131-142

    • DOI

      10.1164/rccm.201504-0760oc

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of periostin in respiratory disorders2016

    • Author(s)
      Izuhara K, Conway SJ, Moore BB, Matsumoto H, Holweg CTJ, Matthews JG, Arron JR
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine

      Volume: 193 Issue: 9 Pages: 949-956

    • DOI

      10.1164/rccm.201510-2032pp

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevation of serum squamous cell carcinoma antigen 2 in patients with psoriasis: associations with disease severity and response to the treatment.2016

    • Author(s)
      Watanabe Y, Yamaguchi Y et al.
    • Journal Title

      Br J Dermatol

      Volume: in press Issue: 6 Pages: 1327-1336

    • DOI

      10.1111/bjd.14426

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria2016

    • Author(s)
      Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, Park GH, Choi JH
    • Journal Title

      Allergy, Asthma & Immunology Research

      Volume: 8 Issue: 5 Pages: 457-460

    • DOI

      10.4168/aair.2016.8.5.457

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multidimensional endotyping in severe asthma reveals inflammatory heterogeneity in MMPs and YKL-402016

    • Author(s)
      Hinks T, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanovi; R, Kurukulaaratchy R, Chauhan A, Howarth PH
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 138 Issue: 1 Pages: 61-75

    • DOI

      10.1016/j.jaci.2015.11.020

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases.2016

    • Author(s)
      Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K.
    • Journal Title

      J Allergy Clin Immunol

      Volume: Epub ahead of print Issue: 2 Pages: 0-0

    • DOI

      10.1016/j.jaci.2015.11.039

    • NAID

      40020962730

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Using periostin as a biomarker in the treatment of asthma2016

    • Author(s)
      Izuhara K, Ohta S, Ono S
    • Journal Title

      Allergy, Asthma and Immunology Research

      Volume: 8 Issue: 6 Pages: 491-498

    • DOI

      10.4168/aair.2016.8.6.491

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Allergen immunotherapy for allergic asthma: protocol for a systematic review2016

    • Author(s)
      Dhami S, Nurmatov U, Agache I, Lau S, Muraro A, Jutel M, Roberts G, Akdis C, Bonini M, Calderon M, Casale T, Cavkaytar O, Cox L, Demoly P, Flood B, Hamelmann E, Izuhara K
    • Journal Title

      Clinical and Translational Allergy

      Volume: 6 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s13601-016-0094-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Periostin as a biomarker for diagnosis of pediatric asthma2016

    • Author(s)
      Inoue T, Akashi K, Watanabe M, Ikeda Y, Ashizuka S, Motoki T, Suzuki R, Sagara N, Yanagida N, Sato S, Ebisawa M, Ohta S, Ono J, Izuhara K, Katunuma T
    • Journal Title

      Pediatric Allergy and Immunology

      Volume: 27 Issue: 5 Pages: 521-526

    • DOI

      10.1111/pai.12575

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma.2016

    • Author(s)
      Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ohta S, Ito I, Oguma T, Inoue H, Iwata T, Kanemitsu Y, Nagasaki T, Niimi A, Mishima M.
    • Journal Title

      Allergy

      Volume: 未定 Issue: 10 Pages: 1472-1479

    • DOI

      10.1111/all.12922

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical implication of the serum periostin level for differentiating phenotypes of NSAID hypersensitivity2016

    • Author(s)
      Kim M, Yoon MK, Lee Y-S, Izuhara K, Ohta S, Ono J, Kim J-H, Ban GY, Ye Y-M, Park H-S
    • Journal Title

      Allergology International

      Volume: 65 Issue: 4 Pages: 492-494

    • DOI

      10.1016/j.alit.2016.04.013

    • NAID

      130005431272

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The potential for repositioning antithyroid agents as antiasthma drugs2016

    • Author(s)
      Suzuki S, Ogawa M, Ohta S, Arima K, Nunomura S, Nanri Y, Mitamura Y, Yoshihara T, Nakamura Y, Yamauchi K, Chibana K, Ishii Y, Lee JJ, Aratani Y, Kakuta S, Kubo S, Iwakura Y, Yoshida H, Izuhara K.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 138 Issue: 5 Pages: 1458

    • DOI

      10.1016/j.jaci.2016.04.047

    • URL

      https://pure.teikyo.jp/en/publications/550604d6-0884-4fad-8c75-2eddad633333

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction.2016

    • Author(s)
      Sugiyama A, Kanno K, Nishimichi N, Yokosaki Y, Izuhara K, Ono J, Tazuma S.
    • Journal Title

      J Gastroenteroln

      Volume: in press Issue: 12 Pages: 1161-1174

    • DOI

      10.1007/s00535-016-1206-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Induction of airway allergic inflammation by hypothiocyanite via epithelial cells2016

    • Author(s)
      Suzuki S, Ogawa M, Ohta S, Nunomura S, Nanri Y, Shiraishi H, Mitamura Y, Yoshihara T, James J. Lee, Izuhara K
    • Journal Title

      Journal of Biological Chemistry

      Volume: 291 Issue: 53 Pages: 27219

    • DOI

      10.1074/jbc.m116.746909

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis2015

    • Author(s)
      Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K-i, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 1 Pages: 41-48

    • DOI

      10.1016/j.alit.2014.06.001

    • NAID

      130004873124

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis2015

    • Author(s)
      Tajiri, M., Okamoto, M., Fujimoto, K., Johkoh, T., Ono, J., Tominaga, M., Azuma, K., Kawayama, T., Ohta, S., Izuhara, K. & Hoshino, T.
    • Journal Title

      Respiratory investigation

      Volume: 53 Issue: 2 Pages: 73-81

    • DOI

      10.1016/j.resinv.2014.12.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phenotype of asthma related with high serum periostin levels2015

    • Author(s)
      Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 2 Pages: 175-180

    • DOI

      10.1016/j.alit.2014.07.003

    • NAID

      130005290305

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of CD163 in vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy: possible involvement of periostin2015

    • Author(s)
      Kobayashi Y, Yoshida S, Nakama T, Zhou Y, Ishikawa K, Arita R, Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T, Ishibashi T
    • Journal Title

      Brit J Ophthalmol

      Volume: 99 Issue: 4 Pages: 451-456

    • DOI

      10.1136/bjophthalmol-2014-305321

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periostin in the bronchial lavage fluid of asthma patients2015

    • Author(s)
      akamura, Y., Nagashima, H., Ohta, S., Ono, J., Yamauchi, K. & Izuhara, K.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 2 Pages: 209-210

    • DOI

      10.1016/j.alit.2015.01.001

    • NAID

      130005290284

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] No increase in the serum periostin level is detected in elementary school-age children with allergic diseases2015

    • Author(s)
      Inoue, Y., Izuhara, K., Ohta, S., Ono, J. & Shimojo, N.
    • Journal Title

      Allergology International

      Volume: 64 Issue: 3 Pages: 289-290

    • DOI

      10.1016/j.alit.2015.04.001

    • NAID

      130005290276

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.2015

    • Author(s)
      Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0129704-e0129704

    • DOI

      10.1371/journal.pone.0129704

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Serum periostin levels correlate with airway hyperresponsiveness to methacholine and mannitol in children with asthma2015

    • Author(s)
      Song JS, You JS, Jeong SI, Yang S, Hwang IT, Im YG, Baek HS, Kim HY, Izuhara K
    • Journal Title

      Allergy

      Volume: 70 Issue: 6 Pages: 674-681

    • DOI

      10.1111/all.12599

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent developments regarding periostin in bronchial asthma2015

    • Author(s)
      Izuhara K, Matsumoto H, Ohta S, Ono J, Arima K, Ogawa M
    • Journal Title

      Allergology International

      Volume: 64 Issue: Supplement.1 Pages: 3-10

    • DOI

      10.1016/j.alit.2015.04.012

    • NAID

      130005290263

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy2015

    • Author(s)
      Chen C-Y, Lee J-B, Liu B, Ohta S, Wang P-Y, Kartashov A, Mugge L, Abonia JP, Barski A, Izuhara K, Rothenberg ME, Finkelman FD, Hogan SP, Wang Y-S
    • Journal Title

      Immunity

      Volume: 43 Pages: 788-802

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predicting asthma morbidity in children using proposed markers of Th2-type inflammation2015

    • Author(s)
      Konradsen, J.R., Skantz, E., Nordlund, B., Lidegran, M., James, A., Ono, J., Ohta, S., Izuhara, K., Dahlen, S.E., Alving, K. & Hedlin, G.
    • Journal Title

      Pediatric allergy and immunology

      Volume: 26 Issue: 8 Pages: 772-9

    • DOI

      10.1111/pai.12457

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Chitinase proteins YKL-40 and chitotriosidase are increased in both asthma and COPD2015

    • Author(s)
      James AJ, Reinius LE, Verhoek M, Gomes A, Kupczyk M, Hammar U, Ono J, Ohta S, Izuhara K, Bel E, Kere J, Söderhäll C, Dahlén B, Boot RG, Dahlén S
    • Journal Title

      Am J Respir Crit Care Med

      Volume: 193 Issue: 9 Pages: 131-142

    • DOI

      10.1371/journal.pone.0024399

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Allergen immunotherapy for allergic asthma: protocol for a systematic review2015

    • Author(s)
      Dhami S, et al.
    • Journal Title

      Clin Transl Allergy

      Volume: 6 Issue: 1 Pages: 12-12

    • DOI

      10.1186/s13601-016-0099-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased expression of M-CSF and IL-13 in vitreous of patients with proliferative diabetic retinopathy: implications for M2 macrophage-involving fibrovascular membrane formation.2014

    • Author(s)
      Yoshida S, Kobayashi Y, Nakama T, Zhou Y, Ishikawa K, Arita R,Nakao S, Miyazaki M, Sassa Y, Oshima Y, Izuhara K, Kono T,Ishibashi T
    • Journal Title

      Br J Ophthalmol

      Volume: 99 Issue: 5 Pages: 629-634

    • DOI

      10.1136/bjophthalmol-2014-305860

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Serum squamous cell carcinoma antigen-2 is a highly sensitive biomarker for atopic dermatitis in children2018

    • Author(s)
      Kawano T, Nagao M, Fujisawa T, Odajima H, Inagaki S, Ohya Y, Azuma Y, Nomura N, Izuhara K
    • Organizer
      AAAAI Annual Meeting / World Allergy Congress (WAC) 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An elevated circulating level of periostin in patients with systemic sclerosis: associations with functional impairment in various affected organs2017

    • Author(s)
      Yamaguchi Y, Shirai Y, Ono J, Kawaguchi Y, Izuhara K, Kuwana M, Aihara M
    • Organizer
      76th Society for Investigative Dermatology Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-year follow-up on exacerbation rate in severe2017

    • Author(s)
      Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Suzuki M, Ono J, Ohta S, Izuhara K, Nishimura M
    • Organizer
      American Thoracic Society (ATS)2017 International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between serum monomeric periostin and the prognosis in patients with acute exacerbation of fibrosing interstitial pneumonia2017

    • Author(s)
      Shimizu H, Sakamoto S, Isshiki T, Urabe N, Suzuki A, Gocho K, Sano G, Sugino K, Isobe K, Takai Y, Okamoto M, Hoshino T, Izuhara K, Homma S
    • Organizer
      American Thoracic Society (ATS)2017 International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decreased lung function relates to increased type-2 inflammation in asthma subjects from the swedish ga2len study2017

    • Author(s)
      Mogensen I, Alving K, James A, Ono J, Ohta S, Izuhara K, Forsberg B, Dahlen S, Janson C, Malinovschi A
    • Organizer
      EAACI Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clarification of the pathogenesis of allergic diseases and application of the findings to clinical medicine2017

    • Author(s)
      Izuhara K
    • Organizer
      5th International Symposium & Exhibition on Aqua Science and Water Resources (ISASWR'17)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Monitoring the inflammatory heterogeneity in asthma with multiple biomarkers for multidimentional endotyping2017

    • Author(s)
      Agache I, Strasser DS, Pierlot GM, Farine H, Izuhara K, Akdis CA
    • Organizer
      European Respiratory Society (ERS) International Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of periostin in patients with severe obstructive sleep apnea2017

    • Author(s)
      Sunadome H, Matsumoto H, Tachikawa R, Matsumoto T, Tanizawa K, Oga T, Izuhara K, Chin K, Ono J, Ohta S
    • Organizer
      European Respiratory Society (ERS) International Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Risks for asthma exacerbations in patients with type 2-low endotype2017

    • Author(s)
      Ishiyama Y, Matsumoto H, Sunadome H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Kanemitsu Y, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Izuhara K, Mishima M
    • Organizer
      European Respiratory Society (ERS) International Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predictors of sputum and BAL eosinophilia in the Wessex Severe Asthma Cohort2017

    • Author(s)
      Jones T, Brown T, Elliott S, Barber C, Gove K, Lau L, Rupani H, Chauhan A, Howarth P, Ono J, Izuhara K
    • Organizer
      European Respiratory Society (ERS) International Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling2017

    • Author(s)
      Kataoka M, Yamaguchi Y, Koumitsu N, Arima K, Izuhara K, Aihara M
    • Organizer
      47th Annual ESDR Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serum tenascin-C levels in patients with asthma2017

    • Author(s)
      Harada N, Asaji M, Harada S, Ishimori A, Katsura Y, Itoigawa Y, Matsuno K, Makino F, Ito J, Ono J, Tobino K, Akiba H, Atsuta R, Izuhara K, Takahashi K
    • Organizer
      The Asian Pacific Society of Respirology (APSR) Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血清ペリオスチン低値喘息群における増悪因子2017

    • Author(s)
      石山祐美、松本久子、金光禎寛、東田有智、堀口高彦、北英夫、桑原和伸、富井啓介、大塚浩二郎、藤村政樹、大倉徳幸、富田桂公、横山彰仁、大西広志、中野恭幸、小熊哲也、保澤総一郎、新実彰男、出原裕美、長崎忠雄、小熊毅、田尻智子、伊藤功朗、出原賢治、三嶋理晃
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重症閉塞性睡眠時無呼吸症候群における血清ペリオスチン値2017

    • Author(s)
      砂留広伸、松本久子、立川良、松本健、谷澤公伸、小賀徹、出原賢治、陳和夫
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規Periostin ELISAシステムを用いた肺線維症特異的バイオマーカーの探索研究2017

    • Author(s)
      岡元政樹、太田昭一郎、小野純也、出原賢治、星野智昭
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 好酸球性肺炎の気管支肺胞洗浄液ではペリオスチン濃度が上昇している2017

    • Author(s)
      中込一之、中村豊、小林威仁、太田昭一郎、小野純也、野口哲、杣知行、坂本芳雄、山内広平、出原賢治、永田真
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 気管支喘息症例における末消血自然リンパ球2017

    • Author(s)
      石森絢子、原田紀宏、原田園子、松野圭、浅地美奈、牧野文彦、伊藤潤、熱田了、千葉麻子、出原賢治、三宅幸子、高橋和久
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アレルギー性気管支肺アスペルギルス症におけるペリオスチン発現2017

    • Author(s)
      田中淳、小熊剛、蛇澤晶、原田一樹、友松克允、松坂雅子、加畑宏樹、福永興壱、別役智子、小野純也、太田昭一郎、出原賢冶、 浅野浩一郎
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] NOGhIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発2017

    • Author(s)
      丸岡秀一郎、伊藤亮治、布村聡、権寧博、曽田香織、太田昭一郎、出原賢治、伊藤守、橋本修
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 線維化型間質性肺炎急性憎悪における血清Periostin値と予後の検討2017

    • Author(s)
      清水宏繁、坂本晋、一色琢磨、ト部尚久、後町杏子、佐野剛、杉野圭史、磯部和順、高井雄二郎、岡本昌樹、星野友昭、出原賢治、本間栄
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 気道上皮細胞は平滑筋細胞からのペリオスチン産生を亢進させる2017

    • Author(s)
      知花和行、堀金有紀子、渡邊泰治、 塩原太一、清水泰生、武政聡浩、小野純也、出原賢治、石井芳樹
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 癌抗原SCCA-2 は小児アトピー性皮膚炎の優れたバイオマーカーである2017

    • Author(s)
      竹内聡、古庄憲弘、小野純也、竹村正規、江崎仁一、三田村康貴、 東義則、林純、出原賢治、古江増隆
    • Organizer
      第116回日本皮膚科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペリオスチンによる副鼻腔炎のフェノタイピング2017

    • Author(s)
      二ノ宮貴裕、野口恵美子、春名威範、長谷川雅世、吉田拓人、山下ゆき子、岡野光博、吉田尚弘、春名眞一、佐久間康徳、太田昭一郎、出原賢治、岡田昌史、徳永貴広、坂下雅文、高林哲司、藤枝重治
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清ペリオスチン低値の喘息例における増悪因子の検討2017

    • Author(s)
      石山祐美、松本久子、金光禎寛、東田有智、堀口高彦、北英夫、桑原和伸、富井啓介、大塚浩二郎、藤村政樹、大倉徳幸、冨田桂公、横山彰仁、大西広志、中野恭幸、小熊哲也、保澤総一郎、新実彰男、出原賢治、三嶋理晃
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 気道上皮細胞は平滑筋細胞からのペリオスチン発現を亢進させる2017

    • Author(s)
      塩原太一、知花和行、堀金有紀子、渡邊泰治、清水泰生、武政聡浩、小野純也、出原賢治、石井芳樹
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Omalizumab投与後も増悪が残る重症喘息例の検討2017

    • Author(s)
      森本千絵、田尻智子、松本久子、出原裕美、権寧博、伊藤玲子、橋本修、出原賢治、太田昭一郎、小野純也、鈴川真穂、大田健、金光禎寛、長崎忠雄、小熊毅、伊藤功朗、新実彰男、三嶋理晃
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 好酸球性肺炎の気管支肺胞洗浄液におけるペリオスチン及びサイトカイン濃度の解析2017

    • Author(s)
      中込一之、中村豊、小林威仁、太田昭一郎、小野純也、野口哲、杣知行、坂本芳雄、山内広平、出原賢治、永田真
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非アレルギー児における年齢別血清ペリオスチン値 第2報2017

    • Author(s)
      藤谷宏子、太田伸男、藤川詩織、春日彩季、比嘉勇介、新宅治夫、小野純也、出原賢治
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ペリオスチントランスジェニックマウスにおける創傷治癒の遅延2017

    • Author(s)
      布村聡,太田昭一郎、小川雅弘,南里康弘、三田村康貴、吉原智仁、 出原賢治
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト線維細胞におけるSOX11を介したIL-13依存性のペリオスチン発現の誘導2017

    • Author(s)
      三田村康貴、布村聡、小川雅弘、南里康弘、太田昭一郎、吉原智仁、古江増隆、出原賢治
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小児喘息診断におけるペリオスチンを含むバイオマーカーの組み合わせによる有用性の検討2017

    • Author(s)
      相良長俊、井上隆志、青田明子、赤司賢一、小野純也、出原賢治、勝沼俊雄
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 剖検肺にてペリオスチンの集積を認めた家族性間質性肺炎の急性増悪の一例2017

    • Author(s)
      村田圭祐、古賀康彦、 蜂巣克昌、笠原礼光、 鶴巻寛朗、矢冨正清、小野昭浩、解良恭一、中島希、松村望、横尾英明、布村 聡、太田昭一郎、出原賢治、小野純也、土橋邦生、久田剛志
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性蕁麻疹(CSU)患者における抗FcεRIα鎖(α鎖)自己抗体の解析(第1報)2017

    • Author(s)
      伊崎聡志、豊島翔太、西盛信幸、柏倉淳一、布村聡、藤澤大輔、畠田優子、葉山惟大、藤田英樹、羅智靖、照井正、岡山吉道
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性蕁麻疹(CSU)患者におけるIgE自己抗体および抗FcεRIα鎖(α鎖)自己抗体の解析(第2報)2017

    • Author(s)
      伊崎聡志、豊島翔太、西盛信幸、柏倉淳一、布村聡、藤澤大輔、畠田優子、葉山惟大、藤田英樹、羅智靖、照井正、岡山吉道
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 好酸球性多発血管炎性肉芽腫症のバイオマーカーとしてのペリオスチン2017

    • Author(s)
      伊藤潤、谷口正実、福富友馬、渡井健太郎、三井千尋、林浩昭、関谷潔史、粒来崇博、小野純也、原田紀宏、熱田了、出原賢治、高橋和久
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 苦参は好酸球造血及び遊走を阻害することにより好酸球性気道炎症を抑制する2017

    • Author(s)
      續啓史、有信洋二郎、宮脇恒太、高木綾子、大田俊一郎、植木尚子、大田友里、Tabrizi SJ、三苫弘喜、赤星光輝、新納宏昭、堀内孝彦、太田昭一郎、出原賢治、水口博之、福井裕行、塚本浩、赤司浩一
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス慢性喘息モデルを用いたペリオスチン動態の検討2017

    • Author(s)
      田中圭介、布村聡、太田昭一郎、與語健二、間木麻友、出原賢治、松本義弘
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A novel, automated periostin assay; correlation with a commercial ELISA method and usability as a biomarker for type 2 inflammation2017

    • Author(s)
      Takai M, Ono J, Kamei A, Matsumoto H, Ohta S, Izuhara K
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Squamous cell carcinoma antigen (SCCA)-2 is a potent biomarker for infantile and preschool child atopic dermatitis in Ishigaki Cohort2017

    • Author(s)
      Takeuchi S, Furusyo N, Ono J, Takemura M, Esaki H, Yamamura K, Mitamura Y, Tsuji G, Oda M, Azuma Y, Hayashi J, Izuhara K, Furue M
    • Organizer
      第66回日本アレルギー学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Elevated periostin concentrations in the bronchoalveolar lavage fluid of eosinophilic pneumonia2017

    • Author(s)
      Nakagome K, Ohta S, Soma T, Izuhara K
    • Organizer
      第46回日本免疫学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The IL-13/periostin/IL-24 pathway causes epidermal barrier dysfunction in allergic skin inflammation2017

    • Author(s)
      Mitamura Y, Nunomura S, Ogawa M, Nanri Y, Yoshihara T, Masuoka M, Tuji G, Nakahara T, Furue M, Izuhara K
    • Organizer
      日本研究皮膚科学会(JSID)第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling2017

    • Author(s)
      Kanaoka M, Yamaguchi Y, Komitsu N, Arima K, Izuhara K, Aihara M
    • Organizer
      日本研究皮膚科学会(JSID)第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Integration of periostin and M2 macrophages in human and murine melanoma progression2017

    • Author(s)
      Ohno F, Nakahara T, Nakahara M, Nunomura S, Izuhara K, Furue M
    • Organizer
      日本研究皮膚科学会(JSID)第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Anti-FcεRIα and IgE autoantibodies of the chronic spontaneous urticaria patients may have the ability of crosslinking of FcεRI.2017

    • Author(s)
      Izaki S, Toyoshima S, Nunomura S, Kanegae K, Kashiwakura J, Nakamura R, Sakamoto T, Nishimori N, Endo T, Akiyama H, Hayama K, Ra C, Okayama Y, Terui T
    • Organizer
      日本研究皮膚科学会(JSID)第42回年次学術大会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] アレルギー疾患の治療薬最前線-2型サイトカインの標的薬2017

    • Author(s)
      出原賢治
    • Organizer
      第4回総合アレルギー講習会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A case of Eosinophilic fasciitis immunohistochemically positive for Periostin2017

    • Author(s)
      Mori M, Masuoka M, Nagase K, Inoue T, Izuhara K, Narisawa Y
    • Organizer
      第69回日本皮膚科学会西部支部学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規治療薬のコンパニオン診断2016

    • Author(s)
      出原賢治
    • Organizer
      第3回日本アレルギー学会総合アレルギー講習会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] アレルギー疾患とペリオスチン2016

    • Author(s)
      出原賢治
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-19
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Allergology Internationalから観た英文論文作製の注意点とコツ2016

    • Author(s)
      出原賢治
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The potential for repositioning anti-thyroid agents as anti-asthma drugs2016

    • Author(s)
      Izuhara K, Suzuki S, Ogawa M, Ohta S, Nanri Y
    • Organizer
      31st Collegium Internationale Allergologicum
    • Place of Presentation
      Charleston (USA)
    • Year and Date
      2016-04-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] アレルギー性炎症の慢性化機序2016

    • Author(s)
      出原賢治
    • Organizer
      第34回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      鳥羽
    • Year and Date
      2016-02-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 分子標的の探索2015

    • Author(s)
      出原賢治
    • Organizer
      第2回日本アレルギー学会総合アレルギー講習会
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 気管支喘息治療における新時代の幕開け2015

    • Author(s)
      出原賢治
    • Organizer
      第53回日本内科学会近畿支部生涯教育講演会
    • Place of Presentation
      神戸
    • Year and Date
      2015-11-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] マトリセルラータンパク質であるペリオスチンによる炎症惹起機序とその臨床応用2015

    • Author(s)
      出原賢治
    • Organizer
      第19回日本内分泌病理学会学術総会
    • Place of Presentation
      佐賀
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Potential protein markers for asthma2015

    • Author(s)
      Izuhara K
    • Organizer
      XXIV World Allergy Congress
    • Place of Presentation
      Seoul
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent progress in the basic research of periostin in bronchial asthma2015

    • Author(s)
      出原賢治
    • Organizer
      第25回国際喘息学会日本・北アジア部会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 喘息におけるバイオマーカー レビュートーク2015

    • Author(s)
      出原賢治
    • Organizer
      第64回日本アレルギー学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 間質性肺炎特異的ペリオスチン測定キットの開発2015

    • Author(s)
      出原賢治
    • Organizer
      第55回日本呼吸器学会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] Evolution of Atopic Dermatitis in the 21st Century: Cytokine Network2018

    • Author(s)
      Izuhara K, Nunomura S, Ohta S, Ogawa M, Nanri Y
    • Total Pages
      381
    • Publisher
      Springer Nature Singapore
    • ISBN
      9789811055409
    • Related Report
      2017 Annual Research Report
  • [Book] The role of pendrin in health and disease: The role of pendrin in the airways: Links with asthma and COPD2017

    • Author(s)
      Izuhara K, Suzuki S, Nofziger C, Ogawa M, Ohta S, Nanri Y, Mitamura Y, Yoshihara T, Pedemonte N, Galietta LJV, Paulmichl M
    • Total Pages
      226
    • Publisher
      Springer International Publishing Switzerland
    • ISBN
      9783319432854
    • Related Report
      2017 Annual Research Report
  • [Book] 内科学 第11版:アレルギーに関与する細胞・分子2017

    • Author(s)
      出原賢治
    • Total Pages
      2385
    • Publisher
      朝倉書店
    • ISBN
      9784254322705
    • Related Report
      2017 Annual Research Report
  • [Book] llergies: Current challenges and solutions2016

    • Author(s)
      Izuhara K, Matsumoto H, Nagasaki T, Ohta S, Ono J, Kinki Hokuriku Airway Disease Conference
    • Total Pages
      239
    • Publisher
      Pacini Editore Medicina
    • Related Report
      2016 Research-status Report
  • [Book] Annual Review 2015 呼吸器2015

    • Author(s)
      出原賢治、有馬和彦、太田昭一郎
    • Total Pages
      252
    • Publisher
      中外医学社
    • Related Report
      2015 Research-status Report
  • [Remarks] 佐賀大学医学部分子生命科学講座分子医化学ホームページ

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2016 Research-status Report
  • [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野

    • URL

      http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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