| Project/Area Number |
15K15374
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KIRINO Yohei 横浜市立大学, 医学部, 講師 (50468154)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 成人スティル病 / マクロファージ / ヘムオキシゲナーゼ1 / フェリチン / ヘムオキシゲナーゼ / ＨＯ－１ |
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| Outline of Final Research Achievements |
In the current study, we collected sera from a total of 145 AOSD patients. These AOSD' patients were further divided into active, remission, and relapse groups. Forty-six cases of systemic vasculitis, sepsis, etc. were included as disease controls. We found that serum ferritin and HO-1 levels were significantly higher in active and relapsed AOSD cases, and were reduced by the treatment. Although a significant correlation was found between serum ferritin and HO-1 levels, a discrepancy was found in some cases such as iron-deficiency anemia.ROC analysis identified optimal levels of serum ferritin (>819 ng/ml; sensitivity 76.1% and specificity 73.8%), and serum HO-1 (>30.2 ng/ml; sensitivity 84.8% and specificity 83.3%) that differentiated AOSD from controls. Interestingly, 88.9% of patients with AOSD who relapsed exceeded the cut-off value of serum HO-1, but only 50.0% exceeded serum ferritin , suggesting that serum HO-1 levels may be a convenient indicator of AOSD disease status.
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