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The development of anti-allergy therapies targeting several inhibitory receptors

Research Project

Project/Area Number 15K15376
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionJuntendo University

Principal Investigator

Kitaura Jiro  順天堂大学, 医学(系)研究科(研究院), 先任准教授 (30282651)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー / 抑制型受容体 / 脂質 / マスト細胞
Outline of Final Research Achievements

Binding and reporter assays using an extracellular domain of inhibitory receptors showed that mast cell inhibitory receptors tested, except for LMIR1 and LMIR3, failed to recognize specific lipids. While the binding of ceramide to LMIR3 inhibited FceRI signals in vitro and in vivo, the interaction between phosphatidylserine and LMIR1 failed to do so. Accordingly, the inhibitory effect of vesicles containing both ceramide and phosphatidylserine on FceRI-mediated mast cell activation was weaker than that of vesicles containing ceramide alone. Thus, administering vesicles containing lipid ligands for LMIR3 might be effective for allergic diseases.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.2017

    • Author(s)
      Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J
    • Journal Title

      J Biol Chem.

      Volume: 292 Issue: 7 Pages: 2924-2932

    • DOI

      10.1074/jbc.m116.768366

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.2015

    • Author(s)
      Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J
    • Journal Title

      Gut

      Volume: 印刷中 Issue: 5 Pages: 1-11

    • DOI

      10.1136/gutjnl-2014-308900

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection.2015

    • Author(s)
      Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A
    • Journal Title

      J Virol

      Volume: 90 Issue: 1 Pages: 92-102

    • DOI

      10.1128/jvi.01849-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells.2015

    • Author(s)
      Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T
    • Journal Title

      Journal of immunology

      Volume: 195(7) Issue: 7 Pages: 3427-3435

    • DOI

      10.4049/jimmunol.1402856

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Ceramide-CD300f interaction inhibits Mrgprb2-mediated pseudo-allergic drug reactions in mice.2017

    • Author(s)
      Hatayama Tomoki, Takamori Ayako, Izawa Kumi, Maehara Akie, Isobe Masamichi, Kaitani Ayako, Uchida Shino, Nakano Nobuhiro, Maeda Keiko, Ando Tomoaki, Okumura Ko, Kitamura Toshio, Kitaura Jiro
    • Organizer
      第45回日本免疫学会
    • Place of Presentation
      Okinawa Convention Center・Laguna Garden Hotel、沖縄
    • Year and Date
      2017-12-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 敗血症性腹膜炎におけるセラミド-CD300fシグナルの役割2016

    • Author(s)
      伊沢久未、奥村康、北浦次郎
    • Organizer
      第9回セラミド研究会学術集会
    • Place of Presentation
      東京ユビキタス協創広場CANVAS、東京
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Inhibition of allergic responses by ceramide-CD300f axis.2016

    • Author(s)
      Jiro Kitaura
    • Organizer
      Federation of American Societies for Experimental Biology (FASEB): IgE and Allergy: 50 Years and Onward
    • Place of Presentation
      West Palm Beach, Florida (USA)
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Disrupting ceramide-LMIR3 interaction prevents bacterial sepsis by stimulating neutrophil recruitment2015

    • Author(s)
      伊沢久未、磯部優理、奥村康、北村俊雄、北浦次郎
    • Organizer
      第43回日本臨床免疫学会
    • Place of Presentation
      神戸国際会議場兵庫県)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] セラミドによるアレルギー性炎症の制御2015

    • Author(s)
      北浦次郎
    • Organizer
      第64 回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] マウスおよびヒトLMIR3のリガンド同定と機能解析2015

    • Author(s)
      伊沢久未、奥村康、北村俊雄、北浦次郎
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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