| Project/Area Number |
15K15378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kurano Makoto 東京大学, 医学部附属病院, 講師 (60621745)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / DIC / 多臓器不全 / アポ蛋白M / スフィンゴシン1－リン酸 / スフィンゴシン１－リン酸 / アポリポ蛋白M / スフィンゴシン1-リン酸 / 播種性血管内凝固症候群 |
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| Outline of Final Research Achievements |
We found that the overexpression of apolipoprotein M (ApoM), an apolipoprotein carried on HDL, ameliorated the survival rate and organ injuries caused by the treatment with lipopolysaccharides, while the suppression of apoM deteriorated them. Moreover, we successfully improved the outcomes of the injection with lipopolysaccharides with recombinant apoM. These findings suggest that apoM can be applied to the treatment with DIC and/or multiple organ failure which occur consequently to sepsis.
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