Establish of novel therapy for DIC and multiple organ failures with apolipoprotein M
Project/Area Number |
15K15378
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
|
Research Institution | The University of Tokyo |
Principal Investigator |
Kurano Makoto 東京大学, 医学部附属病院, 講師 (60621745)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 敗血症 / DIC / 多臓器不全 / アポ蛋白M / スフィンゴシン1-リン酸 / スフィンゴシン1-リン酸 / アポリポ蛋白M / スフィンゴシン1-リン酸 / 播種性血管内凝固症候群 |
Outline of Final Research Achievements |
We found that the overexpression of apolipoprotein M (ApoM), an apolipoprotein carried on HDL, ameliorated the survival rate and organ injuries caused by the treatment with lipopolysaccharides, while the suppression of apoM deteriorated them. Moreover, we successfully improved the outcomes of the injection with lipopolysaccharides with recombinant apoM. These findings suggest that apoM can be applied to the treatment with DIC and/or multiple organ failure which occur consequently to sepsis.
|
Report
(3 results)
Research Products
(12 results)
-
-
[Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017
Author(s)
Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
-
Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 24
Issue: 9
Pages: 954-969
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.2016
Author(s)
Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
-
Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0149462-e0149462
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Presentation] Sphingosine 1-Phosphate Possesses the Carrier-dependent Effects on the Plasminogen Activator Inhibitor 1 Expression in Adipocytes.2016
Author(s)
Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
Organizer
AHA Scientific Sessions 2016.
Place of Presentation
New Orleans, Louisiana, USA.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
-
-
-
-
-
-