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Establish of novel therapy for DIC and multiple organ failures with apolipoprotein M

Research Project

Project/Area Number 15K15378
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Kurano Makoto  東京大学, 医学部附属病院, 講師 (60621745)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords敗血症 / DIC / 多臓器不全 / アポ蛋白M / スフィンゴシン1-リン酸 / スフィンゴシン1-リン酸 / アポリポ蛋白M / スフィンゴシン1-リン酸 / 播種性血管内凝固症候群
Outline of Final Research Achievements

We found that the overexpression of apolipoprotein M (ApoM), an apolipoprotein carried on HDL, ameliorated the survival rate and organ injuries caused by the treatment with lipopolysaccharides, while the suppression of apoM deteriorated them. Moreover, we successfully improved the outcomes of the injection with lipopolysaccharides with recombinant apoM. These findings suggest that apoM can be applied to the treatment with DIC and/or multiple organ failure which occur consequently to sepsis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate among Lipoproteins and in the Modulation of its Functions2017

    • Author(s)
      Kurano, M., Hara, M., Ikeda, H., Tsukamoto, K., and Yatomi, Y
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol.

      Volume: 37 Issue: 3 Pages: 506

    • DOI

      10.1161/atvbaha.116.308692

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 9 Pages: 954-969

    • DOI

      10.5551/jat.37663

    • NAID

      130006038432

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence2016

    • Author(s)
      Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0149462-e0149462

    • DOI

      10.1371/journal.pone.0149462

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resveratrol exerts a biphasic effect on apolipoprotein M2016

    • Author(s)
      Kurano M, Hara M, Nojiri T, Ikeda H, Tsukamoto K, Yatomi Y.
    • Journal Title

      Br J Pharmacol

      Volume: 173 Issue: 1 Pages: 222

    • DOI

      10.1111/bph.13360

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] リコンビナントアポ蛋白Mを利用した多臓器不全に対する新規治療法の開発.2016

    • Author(s)
      蔵野 信,矢冨 裕.
    • Organizer
      第56回 日本臨床化学会年次学術集会.
    • Place of Presentation
      熊本
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sphingosine 1-Phosphate Possesses the Carrier-dependent Effects on the Plasminogen Activator Inhibitor 1 Expression in Adipocytes.2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
    • Organizer
      AHA Scientific Sessions 2016.
    • Place of Presentation
      New Orleans, Louisiana, USA.
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Carrier-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression in Adipocytes.2016

    • Author(s)
      Takahashi, C., Kurano, M., Nishikawa, M., and Yatomi, Y.
    • Organizer
      The 9th Congress of the Asia Pacific Society on Thrombosis and Hemostasis
    • Place of Presentation
      Taipei, Chinese Taipei.
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アポ蛋白Mを用いた播種性血管内凝固症候群,多臓器不全の新規治療法の開発2016

    • Author(s)
      蔵野 信,常山 幸一,常名 政弘,矢冨 裕.
    • Organizer
      第38回 日本血栓止血学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] アポ蛋白Mを用いた播種性血管内凝固症候群、多臓器不全の新規治療法の開発2016

    • Author(s)
      蔵野 信、常山 幸一、常名 政弘、矢冨 裕
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム(奈良・奈良市)
    • Year and Date
      2016-06-16
    • Related Report
      2015 Research-status Report
  • [Presentation] アポ蛋白Mを通じたスフィンゴシン1-リン酸学の構築.2015

    • Author(s)
      蔵野 信
    • Organizer
      第55回 日本臨床化学会学術集会
    • Place of Presentation
      大阪大学コンベンションセンター(大阪・吹田市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 実験医学 増刊号2015

    • Author(s)
      蔵野 信,可野 邦行,矢冨 裕,青木 順賢
    • Total Pages
      221
    • Publisher
      羊土社
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京大学医学部附属病院 検査部

    • URL

      http://lab-tky.umin.jp/index.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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