| Project/Area Number |
15K15401
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 昌利 東北大学, 大学病院, 講師 (00451584)
北西 龍太 東北大学, 大学病院, 助手 (20436116)
埴田 卓志 東北大学, 大学病院, 助手 (30400360)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 人工胎盤 / 人工換気 / 新生児蘇生 / 遷延性肺高血圧 / 胎児仮死 / 呼吸窮迫症候群 / ヒツジ胎仔 / 動物実験 / ヒツジ / 胎仔 / 胎仔仮死 / 胎児機能不全 / 蘇生 / 新生児遷延性肺高血圧 / 適応障害 |
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| Outline of Final Research Achievements |
The study was performed to make clear the efficacy of a pumpless artificial placenta (AP) as a resuscitation devise on persistent pulmonary hypertension of newborn, induced by antenatal acute hypoxia, using experimentally instrumented fetal sheep. The fetuses were divided into 3 groups, based on methods for resuscitation; a control, mechanical ventilation (MV) and AP groups (each n=3). The total required hours of the MV at 24 hours after the resuscitation was compared between the 3 groups. The time (mean ±SEM) in the MV group (12.3±3.4) showed to be longer than that in the other 2 groups, no difference was found between the control (3.0±3.0) and AP (6.0±6.0) group and 2 of the 3 fetuses in the AP group was not required MV. The results might suggest the potent efficacy of the pumpless AP system as a neonatal resuscitation devise.
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