Identification of novel therapeutic target of melanoma with focus on gain-of-function mutation of SH3 domain of KIT

• Project/Area Number: 15K15414
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Fujita Health University (2016); Nagoya University (2015)
• Principal Investigator: SUGIURA Kazumitsu 藤田保健衛生大学, 医学部, 教授 (70335032)
• Co-Investigator(Renkei-kenkyūsha): KOSHIKAWA Naohiko 神奈川県立がんセンター臨床研究所, がん生物学部, 部長 (70334282)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 悪性黒色腫 / KIT / SH3ドメイン / 色素異常症 / ｃ－ＫＩＴ

Outline of Final Research Achievements

The aims of this study are to identify novel theraputic targets of melanoma caused by KIT mutation, and to elucidate that a novel KIT mutation creates SH3 domain which binds to some proteins which have SH2 domain. Constitutive malignant KIT mutation expressed amelanotic melanocyte cell line, constitutive non-malignant KIT mutaion expressed amelonotic melanocyte cell line, and constitutive wild type KIT expressed amelonotic melonocyte cell line were established. The novel kit mutation was proven to create SH3 domain by proteome analysis. Some binding proteins which bound to the KIT mutation were identified. Moreover, some proteins, which overexpressed in constitutive malignant KIT mutation expressed amelonotic melonocyte cell line, were also identified.

Research Products

• [Journal Article] Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis. (2017)
  • Author(s): Saito-Sasaki N, Izu K, Sawada Y, Hino R, Nakano R, Shimajiri S, Nishimura I, Nakamura H, Sugiura K, Nakamura M.
  • Journal Title: Acta Derm Venereol Volume: 97 Issue: 3 Pages: 410-411
  • DOI: 10.2340/00015555-2527
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Striate palmoplantar keratoderma showing transgrediens in a patient harboring heterozygous nonsense mutations in both DSG1 and SERPINB7. (2017)
  • Author(s): Fukaura R, Takeichi T, Okuno Y, Kojima D, Kono M, Sugiura K, Suga Y, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 97 Issue: 3 Pages: 399-401
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Punctate Palmoplantar Keratoderma Type 1 with a Novel AAGAB Frameshift Mutation: intrafamilial phenotype variation due to aging. (2017)
  • Author(s): Kono M, Fukai K, Shimizu N, Nagao J, Takeichi T, Tsuruta D, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 3
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ripple-pattern lichen amyloidosis in a case of ichthyosis vulgaris with a novel FLG mutation. (2017)
  • Author(s): Kono M, Nishida K, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 2
  • DOI: 10.1111/jdv.13877
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A case of epidermolytic ichthyosis showing a very mild phenotype due to a novel tail extension mutation in KRT10. (2017)
  • Author(s): Kono M, Fukai K, Omura R, Sugawara K, Tsuruta D, K Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 31 Issue: 2
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  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pityriasis rubra pilaris type V as an auto inflammatory disease by CARD14 mutations. (2017)
  • Author(s): Takeichi T, Sugiura K, Nomura T, Sakamoto T, Ogawa Y, Oiso N, Futei Y, Fujisaki A, Koizumi A, Aoyama Y, Nakajima K, Hatano Y, Hayashi K, Akemi Ishida-Yamamoto A, Fujiwara S, Sano S, Iwatsuki K, Kawada A, Suga Y, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: JAMA Dermatol Volume: 153 Issue: 1 Pages: 66-70
  • DOI: 10.1001/jamadermatol.2016.3601
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A newly revealed IL36RN mutation in sibling cases complements our IL36RN mutation statistics for generalized pustular psoriasis. (2017)
  • Author(s): Takeichi T, Togawa Y, Taniguchi R, Okuno Y, Kono M, Matsue H, Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 85 Issue: 1 Pages: 58-60
  • DOI: 10.1016/j.jdermsci.2016.10.009
  • NAID: 120006305585
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Novel and recurrent ATP2A2 mutations in Japanese patients with Darier’s disease (2016)
  • Author(s): Noda K, Takeichi T, Okuno Y, Takama H, Miura S, Kagami S, Hino H, Nakamura Y, Fujio Y, Konohana I, Otani A, Mukai H, Sugiura K, Akiyama M.
  • Journal Title: Nagoya Journal of Medical Science Volume: 78 Issue: 4 Pages: 485-492
  • DOI: 10.18999/nagjms.78.4.485
  • NAID: 120005889988
  • ISSN: 2186-3326
  • URL: https://nagoya.repo.nii.ac.jp/records/22949
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Darier’s Disease Complicated by Schizophrenia Caused by a Novel ATP2A2 Mutation (2016)
  • Author(s): Takeichi T, Sugiura K, Nakamura Y, Fujio Y, Konohana I, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: in press Issue: 7 Pages: 993-994
  • DOI: 10.2340/00015555-2422
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Epididymitis with epididymal cysts indicating IgA vasculitis in an adult. (2016)
  • Author(s): Nanbu A, Sugiura K, Sassa N, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 96 Issue: 7 Pages: 985-986
  • DOI: 10.2340/00015555-2382
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hyperpigmentation over the metacarpophalangeal joints and the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations. (2016)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: - Issue: 10 Pages: 44-46
  • DOI: 10.1111/jdv.13290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A 45-year-old woman with Ehlers-Danlos syndrome caused by dermatan 4-O-sulfotransferase-1 deficiency: implications of dermatan sulfate depletion on early aging. (2016)
  • Author(s): Kono M, Hasegawa-Murakami Y, Sugiura K, Ono M, Toriyama K, Miyake N, Hatamochi A, Kamei Y, Kosho T, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: - Pages: 1-2
  • DOI: 10.2340/00015555-2390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function (2016)
  • Author(s): Takeichi T, Sugiura K, Hsu CK, Nomura T, Takama H, Simpson MA, Shimizu H, McGrath JA, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 96 Issue: 4 Pages: 557-559
  • DOI: 10.2340/00015555-2307
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lipodystrophia centrifugalis abdominalis infantilis accompanied by idiopathic encephalopathy. (2016)
  • Author(s): Kaibuchi-Noda K, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 30 Issue: 5 Pages: 862-864
  • DOI: 10.1111/jdv.13031
  • NAID: 120005844134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutires syndrome 6 are phenotypic variants caused by ADAR1 mutations. (2016)
  • Author(s): Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: J Invest Dermatol. Volume: 136 Issue: 4 Pages: 875-8
  • DOI: 10.1016/j.jid.2015.12.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cutaneous Manifestations in Dermatomyositis: Key Clinical and Serological Features-a Comprehensive Review (2016)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Clin Rev Allergy Immunol Volume: 51 Pages: 293-302
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Unilateral generalized linear porokeratosis with nail dystrophy. (2016)
  • Author(s): Kono M, Yokoyama N, Ogawa Y, Takama H, Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Volume: 43 Issue: 3 Pages: 286-7
  • DOI: 10.1111/1346-8138.13204
  • Peer Reviewed
• [Journal Article] Noteworthy clinical findings of harlequin ichthyosis: Digital autoamputation caused by cutaneous constriction bands in a case with novel ABCA12 mutations (2016)
  • Author(s): Tanahashi K, Sugiura K, Sato T, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 174 Issue: 3 Pages: 689
  • DOI: 10.1111/bjd.14228
  • Peer Reviewed
• [Journal Article] Bi-allelic nonsense mutations in ABHD5 underlie a mild phenotype of Dorfman-Chanarin syndrome. (2016)
  • Author(s): Takeichi T, Sugiura K, Tso S, Simpson MA, McGrath JA, Akiyama M.
  • Journal Title: J Dermatol Sci, Volume: 81 Issue: 2 Pages: 134-6
  • DOI: 10.1016/j.jdermsci.2015.10.015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anti-transcription intermediary factor 1-γ antibody-positive clinically amyopathic dermatomyositis complicated by interstitial lung disease and breast cancer. (2015)
  • Author(s): Ogawa M, Sugiura K, Yokota K, Muro Y, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: 29 Issue: 2 Pages: 373-375
  • DOI: 10.1111/jdv.12797
  • Peer Reviewed
• [Journal Article] Serum thymus and activation-regulated chemokine (TARC/CCL17) levels reflect the disease activity in a patient with bullous pemphigoid. (2015)
  • Author(s): Nin-Asai R, Muro Y, Sekiya A, Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 30 Issue: 2 Pages: 327-328
  • DOI: 10.1111/jdv.12719
  • Peer Reviewed
• [Journal Article] Apparent homozygosity due to compound heterozygosity of one point mutation and an overlapping exon deletion mutation in ABCA12. (2015)
  • Author(s): Shibata A, Sugiura K, Suzuki A, Ichiki T, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 80 Issue: 3 Pages: 196-202
  • DOI: 10.1016/j.jdermsci.2015.10.003
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging findings are useful for evaluating the three-dimensional development and follow-up of linear lupus erythematosus profundus. (2015)
  • Author(s): Ogawa M, Muro Y, Sugiura K, Sakakibara A, Akiyama M.
  • Journal Title: Lupus Volume: 24 Issue: 11 Pages: 1214-1216
  • DOI: 10.1177/0961203315574559
  • Peer Reviewed
• [Journal Article] What are the "true" pathogenic anti-desmoglein antibodies? (2015)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 95 Pages: 872-874
  • DOI: 10.2340/00015555-2119
  • Peer Reviewed / Open Access
• [Journal Article] Successful treatment with infliximab of sibling cases with generalized pustular psoriasis caused by deficiency of interleukin-36 receptor antagonist. (2015)
  • Author(s): Sugiura K, Endo K, Akasaka T, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol Volume: 29 Issue: 10 Pages: 2054-6
  • DOI: 10.1111/jdv.12590
  • Peer Reviewed
• [Journal Article] Lamellar ichthyosis caused by a previously unreported homozygous ALOXE3 mutation in East Asia. (2015)
  • Author(s): Sugiura K, Akiyama M.
  • Journal Title: Acta Derm Venereol Volume: 95 Issue: 7 Pages: 858-9
  • DOI: 10.2340/00015555-2022
  • Peer Reviewed / Open Access
• [Journal Article] Porokeratotic eccrine ostial and dermal duct nevus with a somatic homozygous or monoallelic variant of connexin 26. (2015)
  • Author(s): Noda K, Sugiura K, Kono M, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 80 Issue: 1 Pages: 74-6
  • DOI: 10.1016/j.jdermsci.2015.07.003
  • Peer Reviewed
• [Journal Article] Novel indel mutation of STS underlies a new phenotype of self-healing recessive X-linked ichthyosis. (2015)
  • Author(s): Takeichi T, Sugiura K, Chao-Kai Hsu CK, Tanahashi K, Takama H, Michael A Simpson, MA, McGrath JA, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 79 Issue: 3 Pages: 317-9
  • DOI: 10.1016/j.jdermsci.2015.07.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High incidence of cancer in anti-small ubiquitin-like modifier activating enzyme antibody-positive dermatomyositis. (2015)
  • Author(s): Muro Y, Sugiura K, Akiyama M.
  • Journal Title: Rheumatology (Oxford) Volume: 54 Issue: 9 Pages: 1745-1747
  • DOI: 10.1093/rheumatology/kev247
  • Peer Reviewed
• [Journal Article] Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations. (2015)
  • Author(s): Tanahashi K, Sugiura K, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 173 Issue: 3 Pages: 865-6
  • DOI: 10.1111/bjd.13790
  • Peer Reviewed
• [Journal Article] Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. (2015)
  • Author(s): Sugiura K, Nakasuka A, Kono H, Kono M, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 79 Issue: 3 Pages: 319-20
  • DOI: 10.1016/j.jdermsci.2015.06.003
  • Peer Reviewed
• [Journal Article] Dowling-Degos disease with mutations in POFUT1 is clinicopathologically distinct from reticulate acropigmentation of Kitamura. (2015)
  • Author(s): Kono M, Suganuma M, Takama H, Zarzoso I, Saritha M, Bodet D, Aboobacker S, Kaliaperumal K, Suzuki T, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 173 Issue: 2 Pages: 584-6
  • DOI: 10.1111/bjd.13702
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A case of annular pustular psoriasis with heterozygous IL36RN mutation. (2015)
  • Author(s): Miyake T, Umemura H, Doi Y, Kousogabe J, Tsuji K, Hamada T, Sugiura K, Aoyama Y, Akiyama M, Iwatsuki K.
  • Journal Title: Eur J Dermatol Volume: 25 Pages: 349-50
  • Peer Reviewed
• [Journal Article] The novel GJB3 mutation p.Thr202Asn in the M4 transmembrane domain underlies erythrokeratodermia variabilis. (2015)
  • Author(s): Sugiura K, Arima M, Matsunaga K, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 173 Issue: 1 Pages: 309-11
  • DOI: 10.1111/bjd.13641
  • Peer Reviewed
• [Journal Article] Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris. (2015)
  • Author(s): Aizu T, Matsui A, Takiyoshi N, Akasaka E, Kaneko T, Nakano H, Sugiura K, Akiyama M, Sawamura D
  • Journal Title: Case Rep Dermatol Volume: 7 Issue: 2 Pages: 187-193
  • DOI: 10.1159/000438505
  • Peer Reviewed / Open Access
• [Journal Article] Update on autosomal recessive congenital ichthyosis: mRNA analysis using hair samples is a powerful tool for genetic diagnosis. (2015)
  • Author(s): Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 79 Issue: 1 Pages: 4-9
  • DOI: 10.1016/j.jdermsci.2015.04.009
  • Peer Reviewed
• [Journal Article] Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation. (2015)
  • Author(s): Ohno Y, Nakamichi S, Ohkuni A, Kamiyama N, Naoe A, Tsujimura H, Yokose U, Sugiura K, Ishikawa J, Akiyama M, Kihara A.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 112 Issue: 25 Pages: 7707-12
  • DOI: 10.1073/pnas.1503491112
  • NAID: 120005690012
  • Peer Reviewed / Open Access
• [Journal Article] Annular Elastolytic Giant Cell Granuloma Successfully Treated with Minocycline Hydrochloride. (2015)
  • Author(s): Nanbu A, Sugiura K, Kono M, Muro Y, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: in press Issue: 6 Pages: 756-7
  • DOI: 10.2340/00015555-2056
  • Peer Reviewed / Open Access
• [Journal Article] Pustular psoriasis-like lesions associated with hereditary lactate dehydrogenase M subunit deficiency without interleukin-36 receptor antagonist mutation: long-term follow-up of two cases. (2015)
  • Author(s): Ito T , Aoshima M, Sugiura K, Fujiyama T, Ito N, Sakabe JI, Akiyama M, Maekawa M, Tokura Y
  • Journal Title: Br J Dermatol. Volume: Epub Issue: 6 Pages: 1674-6
  • DOI: 10.1111/bjd.13590
  • Peer Reviewed / Open Access
• [Journal Article] Diversity of humoral responses to the centromere proteins among HCV-related chronic liver disease, PBC and AIH patients. (2015)
  • Author(s): Himoto T, Tanaka N, Saito A, Muro Y, Sugiura K, Tani J, Miyoshi H, Morishita A, Yoneyama H, Haba R, Masaki T.
  • Journal Title: Clin Res Hepatol Gastroenterol Volume: 39 Issue: 2 Pages: 222-229
  • DOI: 10.1016/j.clinre.2014.08.004
  • Peer Reviewed
• [Journal Article] TRPS1 haploinsufficiency results in increased STAT3 and SOX9 mRNA expression in hair follicles in trichorhinophalangeal syndrome. (2015)
  • Author(s): Shibata A, Tanahashi K, Sugiura K, Akiyama M
  • Journal Title: Acta Derm Venereol Volume: 95 Issue: 5 Pages: 620-1
  • DOI: 10.2340/00015555-1948
  • Peer Reviewed / Open Access
• [Presentation] 皮膚の自己炎症性疾患、DITRAとCAMPS：遺伝学的研究からわかってきたこと (2016)
  • Author(s): 杉浦一充
  • Organizer: 第40回皮膚科免疫セミナー
  • Place of Presentation: 経団連会館 東京都千代田区
  • Year and Date: 2016-03-05
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International congress of human genetics
  • Place of Presentation: 京都市(京都国際会館）
  • Int'l Joint Research / Invited
• [Presentation] 遺伝性の乾癬：DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第60回日本リウマチ学会総会・学術集会
  • Place of Presentation: 横浜市（パシフィコ横浜）
  • Invited
• [Presentation] 汎発性膿疱性乾癬における膿疱形成のメカニズム (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第115回日本皮膚科学会総会
  • Place of Presentation: 京都市（京都国際会館）
  • Invited
• [Presentation] 意外な遺伝性皮膚疾患 (2016)
  • Author(s): 杉浦一充
  • Organizer: 第276回日本皮膚科学会東海地方会
  • Place of Presentation: 名古屋市（大正製薬(株)中日本支店）
  • Invited
• [Presentation] インターロイキン36受容体拮抗因子欠損と加齢が身体に及ぼす影響の検討 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第12回加齢皮膚医学研究会
  • Place of Presentation: 神戸市（兵庫県医師会館）
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: Asia-Pacific Combined Dermatology Research Conference
  • Place of Presentation: Noosa, Australia(Sofitel Pacific Resort Noosa Hotel)
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: 宇都宮市(ホテル東日本宇都宮)
  • Invited
• [Presentation] IL-36R阻害剤 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第31回日本乾癬学会学術大会
  • Place of Presentation: 宇都宮市(ホテル東日本宇都宮)
  • Invited
• [Presentation] 皮膚科の自己炎症性疾患；DITRAとCAMPS (2016)
  • Author(s): 杉浦 一充
  • Organizer: 日本皮膚科学会愛媛地方会第64回学術大会
  • Place of Presentation: 松山市(いよてつ会館)
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 12th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: 東京都文京区(東京医科歯科大学)
  • Int'l Joint Research / Invited
• [Presentation] 膿疱症とDITRA(deficiency of interleukin-36 receptor antagonist) (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第32回日本臨床皮膚科医会 東海北陸ブロック総会
  • Place of Presentation: 名古屋市(キャッスルプラザ)
  • Invited
• [Presentation] IL-36と乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第80回日本皮膚科学会東部支部学術大会
  • Place of Presentation: 浜松市(浜松アクトシティ)
  • Invited
• [Presentation] IL36RN 遺伝子と膿疱性乾癬 (2016)
  • Author(s): 杉浦 一充
  • Organizer: 第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 東京都新宿区(京王プラザホテル)
  • Invited
• [Presentation] Genetic background of generalized pustular psoriasis (2016)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 日本研究皮膚科学会第41回年次学術大会・総会
  • Place of Presentation: 仙台市(仙台国際センター）
  • Invited
• [Presentation] Genetic background of pustular psoriasis (2015)
  • Author(s): Sugiura K.
  • Organizer: 日本研究皮膚科学会第40回年次学術大会・総会
  • Place of Presentation: 岡山コンベンションセンター 岡山県岡山市
  • Year and Date: 2015-12-13
  • Invited
• [Presentation] 膿疱症 up-to-date (2015)
  • Author(s): 杉浦一充
  • Organizer: 平成27年度生涯教育講演会第274回日本皮膚科学会東海地方会
  • Place of Presentation: 大正製薬名古屋支店 愛知県名古屋市
  • Year and Date: 2015-12-06
  • Invited
• [Presentation] 先天性縮毛症・乏毛症 (2015)
  • Author(s): 杉浦一充
  • Organizer: 第20回日本臨床毛髪学会学術集会
  • Place of Presentation: 総合あいしんセンター 高知県高知市
  • Year and Date: 2015-12-05
  • Invited
• [Presentation] 膿疱症 (2015)
  • Author(s): 杉浦一充
  • Organizer: 平成27年度日本皮膚科学会研修講習会（必須Aコース）
  • Place of Presentation: 学術総合センター 東京都千代田区
  • Year and Date: 2015-08-29
  • Invited
• [Presentation] 膿疱性乾癬とAGEPの関係 (2015)
  • Author(s): 杉浦一充
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜 神奈川県横浜市
  • Year and Date: 2015-05-30
  • Invited
• [Patent(Industrial Property Rights)] 関節症性乾癬モデル動物及び膿疱性乾癬モデル動物 (2015)
  • Inventor(s): 秋山真志、杉浦一充、柴田章貴
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-181223
  • Filing Date: 2015-09-14
• [Patent(Industrial Property Rights)] インターロイキン36受容体アンタゴニスと欠損症の治療薬 (2015)
  • Inventor(s): 秋山真志、杉浦一充、柴田章貴
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-254560
  • Filing Date: 2015-12-25