Circadian regulation of sex steroids in aged skin after menopause
| Project/Area Number |
15K15416
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
Masao Doi 京都大学, 薬学研究科(研究院), 准教授 (20432578)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Hitoshi 京都大学, 大学院薬学研究科, 教授 (60158813)
Fustin Jean-Michel 京都大学, 大学院薬学研究科, 特定講師 (50711818)
SASANO Hironobu 東北大学, 大学院医学研究科, 教授 (50187142)
NAKAMURA Yasuhiro 東北大学, 大学院医学研究科, 准教授 (80396499)
KABASHIMA Kenji 京都大学, 大学院医学研究科, 教授 (00362484)
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| Research Collaborator |
YARIMIZU Daisuke
NAKAGAWA Yuuki
TSUJIHANA Kojiro
MURAI Iori
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 概日時計 / 皮膚 / 性ステロイド / ステロイド合成律速酵素 |
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| Outline of Final Research Achievements |
We found that the circadian clock regulates expression of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD), a rate-limiting enzyme of de novo steroid synthesis, and demonstrated that its expression occurs in the sebaceous gland, a sex steroid producing organ in the skin (MCE 2014; MCE 2015). Molecular characterization revealed that expression levels of this enzyme are regulated not only by the circadian clock, but also through stimulus-selective induction of the orphan nuclear receptor, nerve growth factor-induced clone B (EJ 2015). Cutaneously produced steroids are an important source of sex steroids for post-menopausal women. Further investigation into the regulated expression of 3β-HSD may elucidate an important component of the environmental adaptation mechanism of the skin.
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Report
(2 results)
Research Products
(22 results)
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[Journal Article] Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.2016
Author(s)
Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga JI, Matsuoka M, Hastings MH, Kiyonari H, and Okamura H.
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Journal Title
Nat Commun
Volume: 7
Issue: 1
Pages: 10583-10583
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] 3ß-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma2015
Author(s)
Konosu-Fukaya S, Nakamura Y, Satoh F, Ono Y, Felizola SJ, Ise K, Maekawa T, Takeda K, Katsu K, Fujishima F, Kasajima A, Watanabe M, Arai Y, Gomez-Sanchez EP, Gomez-Sanchez CE, Doi M, Okamura H, and Sasano H
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Journal Title
Mol. Cell. Endocrinol.
Volume: 印刷中
Pages: 205-212
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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