| Project/Area Number |
15K15416
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
Masao Doi 京都大学, 薬学研究科(研究院), 准教授 (20432578)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Hitoshi 京都大学, 大学院薬学研究科, 教授 (60158813)
Fustin Jean-Michel 京都大学, 大学院薬学研究科, 特定講師 (50711818)
SASANO Hironobu 東北大学, 大学院医学研究科, 教授 (50187142)
NAKAMURA Yasuhiro 東北大学, 大学院医学研究科, 准教授 (80396499)
KABASHIMA Kenji 京都大学, 大学院医学研究科, 教授 (00362484)
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| Research Collaborator |
YARIMIZU Daisuke
NAKAGAWA Yuuki
TSUJIHANA Kojiro
MURAI Iori
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 概日時計 / 皮膚 / 性ステロイド / ステロイド合成律速酵素 |
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| Outline of Final Research Achievements |
We found that the circadian clock regulates expression of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD), a rate-limiting enzyme of de novo steroid synthesis, and demonstrated that its expression occurs in the sebaceous gland, a sex steroid producing organ in the skin (MCE 2014; MCE 2015). Molecular characterization revealed that expression levels of this enzyme are regulated not only by the circadian clock, but also through stimulus-selective induction of the orphan nuclear receptor, nerve growth factor-induced clone B (EJ 2015). Cutaneously produced steroids are an important source of sex steroids for post-menopausal women. Further investigation into the regulated expression of 3β-HSD may elucidate an important component of the environmental adaptation mechanism of the skin.
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