The role of perivascular adipose tissue in skin immune responses
Project/Area Number |
15K15417
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 肥満 / アレルギー / 免疫 / 皮膚科学 / 免疫学 / 高脂肪食 / 尋常性乾癬 |
Outline of Final Research Achievements |
Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesity models, we found that HFD-fed mice exhibited aggravated psoriatic dermatitis, which was accompanied with increased accumulation of IL-17A-producing Vg4+ gd T cells in the skin. In addition, HFD-fed mice displayed increased expression of several gd T cell-recruiting chemokines in the skin. These results indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Phospholipase Cδ1 regulates p38 MAPK activity and skin barrier integrity.2017
Author(s)
Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura, Kenji Kabashima, Kiyoko Fukami
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Journal Title
Cell Death & Differentiation
Volume: in press
Issue: 6
Pages: 1079-1090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling2017
Author(s)
Ewald DA, Noda S, Oliva M, Litman T, Nakajima S, Li X, Xu H, Workman CT, Scheipers P, Svitacheva N, Labuda T, Krueger JG, Suarez-Farias M, Kabashima K, Guttman-Yassky E
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Journal Title
J Allergy Clin Immunol
Volume: 139
Issue: 2
Pages: 562-572
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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