Elucidation of pathogenic mechanism of vitiligo using mice with Th17-type response.

• Project/Area Number: 15K15418
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Osaka University
• Principal Investigator: Katayama Ichiro 大阪大学, 医学系研究科, 教授 (80191980)
• Co-Investigator(Kenkyū-buntansha): 荒瀬 規子 大阪大学, 医学系研究科, 特任研究員 (30360481) ; 楊 伶俐 大阪大学, 医学系研究科, 特任研究員(常勤) (40711784) ; 越智 沙織 大阪大学, 医学系研究科, 助教 (00597495)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 免疫学 / ストレス / 生体分子 / メラノサイト / MHC / ロドデノール / アポトーシス / モデルマウス / 白斑 / Th17

Outline of Final Research Achievements

We had reported that significant role of Th17 cells in the development of vitiligo. On the other hand, we found that cellular misfolded proteins/ MHC complex resulted in development of autoimmune diseases. Therefore, we considered that these mechanisms might be involved in vitiligo development. Recently, rhododendrol revealed to induce leukoderma like vitiligo. We thought pathogenesis of rhododendrol-induced vitiligo might have implications for understanding vitiligo. We found that melanocytes were damaged with rhododendrol in the presence of ultraviolet light and an inflammatory cytokine. These effects depended on NF-kB activity.
As for establishment of model mice with vitiligo, we cloned several melanocyte antigens of both mice and human, introduced into the expression vector, and confirmed protein expression. We analyzed functions of MHC/melanocyte antigens. We would like to make mice model using the established constructs and the knowledges provided in this study.

Research Products

• [Journal Article] Anti-RNA polymerase III antibody positive limited cutaneous systemic sclerosis with cryoglobulin-induced digital gangrene. (2017)
  • Author(s): Deguchi A, Yamaoka T, Komurasaki Y, Hayashi M, Kiyohara E, Murota H, Katayama I.
  • Journal Title: Clin Exp Dermatol. Volume: 42 Issue: 2 Pages: 200-201
  • DOI: 10.1111/ced.12968
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Exacerbating factors of itch in atopic dermatitis (2017)
  • Author(s): Murota H, Katayama I.
  • Journal Title: Allergology International Volume: 66 Issue: 1 Pages: 8-13
  • DOI: 10.1016/j.alit.2016.10.005
  • NAID: 130005308460
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Japanese guidelines for atopic dermatitis 2017 (2017)
  • Author(s): Katayama I, Aihara M, Ohya Y, Saeki H, Shimojo N, Shoji S, Taniguchi M, Yamada H
  • Journal Title: Allergology International Volume: 66 Issue: 2 Pages: 230-247
  • DOI: 10.1016/j.alit.2016.12.003
  • NAID: 130005628171
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Critical renal adverse event induced by nivolumab therapy in a stage IV melanoma patient. J Dermatol. (2017)
  • Author(s): Tanaka A, Ikinaga K, Kiyohara E, Tanemura A, Wataya-Kaneda M, Fujimura R, Mizui M, Isaka Y, Katayama I
  • Journal Title: J Dermatol. Volume: In print
• [Journal Article] Abberant Sudomotor Functions in Sjögren's Syndrome: Comparable Study with Atopic Dermatitis on Dry Skin Manifestation. (2016)
  • Author(s): Katayama I
  • Journal Title: Curr Probl Dermatol. Volume: 51 Pages: 62-74
  • DOI: 10.1159/000446780
  • ISBN: 9783318059045, 9783318059052
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Histamine Modulates Sweating and Affects Clinical Manifestations of Atopic Dermatitis. (2016)
  • Author(s): Takahashi A, Tani S, Murota H, Katayama I
  • Journal Title: Curr Probl Dermatol. Volume: 51 Pages: 50-6
  • DOI: 10.1159/000446758
  • ISBN: 9783318059045, 9783318059052
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins. (2016)
  • Author(s): Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H.
  • Journal Title: Nature Microbiology Volume: - Issue: 6 Pages: 1-7
  • DOI: 10.1038/nmicrobiol.2016.54
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Local cortisol/corticosterone activation in skin physiology and pathology. (2016)
  • Author(s): Terao M, Katayama I
  • Journal Title: J Dermatol Sci. Volume: 84 Issue: 1 Pages: 11-6
  • DOI: 10.1016/j.jdermsci.2016.06.014
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Olecranon Osteomyelitis Caused by <i>Mycobacterium chelonae</i> (2016)
  • Author(s): Hagiya H, Hayashi M, Katayama I, Tomono K
  • Journal Title: Internal Medicine Volume: 55 Issue: 13 Pages: 1825-1825
  • DOI: 10.2169/internalmedicine.55.6490
  • NAID: 130005161013
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis. (2016)
  • Author(s): Tokumasu R, Yamaga K, Yamazaki Y, Murota H, Suzuki K, Tamura A, Bando K, Furuta Y, Katayama I, Tsukita S.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 113 Issue: 28
  • DOI: 10.1073/pnas.1525474113
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Local corticosterone activation by 11β-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis. (2016)
  • Author(s): Itoi-Ochi S, Terao M, Murota H, Katayama I
  • Journal Title: Dermatoendocrinol. Volume: 8 Issue: 1 Pages: e1119958-e1119958
  • DOI: 10.1080/19381980.2015.1119958
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The effect of rhododendrol inhibition of NF-κB on melanocytes in the presence of tyrosinase. (2016)
  • Author(s): Arase N, Yang L, Tanemura A, Yang F, Suenaga T, Arase H, Katayama I.
  • Journal Title: J Dermatol Sci. Volume: 83 Issue: 2 Pages: 157-159
  • DOI: 10.1016/j.jdermsci.2016.05.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Possible association of pigmentary demarcation line with cervical conization and contraceptives. (2016)
  • Author(s): Shindo S, Murota H, Katayama I
  • Journal Title: J Dermatol. Volume: 43 Issue: 12 Pages: 1444-5
  • DOI: 10.1111/1346-8138.13422
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes: The Role in Hapten-Induced Dermatitis. (2016)
  • Author(s): Terao M, Itoi S, Matsumura S, Yang L, Murota H, Katayama I
  • Journal Title: Am J Pathol. Volume: 186 Issue: 6 Pages: 1499-510
  • DOI: 10.1016/j.ajpath.2016.01.014
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. (2016)
  • Author(s): 3.Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Itoi-Ochi S, Penninger JM, Katayama I, Inohara H and Ishii M
  • Journal Title: Molecular and Cellular Biology Volume: 36 Issue: 11 Pages: 1610-20
  • DOI: 10.1128/mcb.01028-15
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin. (2016)
  • Author(s): Yang L, Murota H, Shindo S, Yang F, Serada S, Fujimoto M, Naka T, Katayama I
  • Journal Title: J Dermatol Sci. Volume: 82 Issue: 1 Pages: 57-9
  • DOI: 10.1016/j.jdermsci.2016.01.004
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Lymphangioleiomyomatosis and multifocal micronodular pneumocyte hyperplasia in Japanese patients with tuberous sclerosis complex (2016)
  • Author(s): Tanaka M, Hirata H, Wataya-Kaneda M*, Yoshida M, Katayama I
  • Journal Title: Respir Investig Volume: 54 Issue: 1 Pages: 8-13
  • DOI: 10.1016/j.resinv.2015.06.003
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow. (2016)
  • Author(s): Hanafusa T, Kato K, Azukizawa H, Miyazaki J, Takeda J, Katayama I.
  • Journal Title: J Dermatol Sci. Volume: 81(3) Issue: 3 Pages: 173-81
  • DOI: 10.1016/j.jdermsci.2015.11.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unique case of postural cholinergic urticaria induced by a standing position. (2016)
  • Author(s): Hirohata A, Yamaoka T, Hayashi M, Murota H, Tani M, Katayama I.
  • Journal Title: Clin Exp Dermatol. Volume: ahead of print Issue: 4 Pages: 439-440
  • DOI: 10.1111/ced.12796
  • Peer Reviewed
• [Journal Article] Evolving understanding on the aetiology of thermally provoked itch. (2016)
  • Author(s): Murota H, Katayama I.
  • Journal Title: Eur J Pain. Volume: 20 Issue: 1 Pages: 47-50
  • DOI: 10.1002/ejp.777
  • Peer Reviewed
• [Journal Article] Psoriatic Arthritis Complicating Systemic Sclerosis: Possible Involvement of M2 Macrophages. (2015)
  • Author(s): Yamaoka T, Inoue T, Kitaba S, Yokomi A, Azukizawa H, Terao M, Murota H, Higashiyama M, Katayama I.
  • Journal Title: Ann Dermatol. Volume: 27 Issue: 5 Pages: 631-2
  • DOI: 10.5021/ad.2015.27.5.631
  • Peer Reviewed
• [Journal Article] A vitamin D analog inhibits Th2 cytokine- and TGFβ -induced periostin production in fibroblasts: a potential role for vitamin D in skin sclerosis. (2015)
  • Author(s): Terao M, Yang L, Matsumura S, Yutani M, Murota H, Katayama I.
  • Journal Title: Dermatoendocrinol. Volume: 7 Issue: 1 Pages: e1010983-e1010983
  • DOI: 10.1080/19381980.2015.1010983
  • Peer Reviewed
• [Journal Article] Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. (2015)
  • Author(s): Hirobe S, Azukizawa H, Hanafusa T, Matsuo K, Quan YS, Kamiyama F, Katayama I, Okada N, Nakagawa S.
  • Journal Title: Biomaterials. Volume: 57 Pages: 50-8
  • DOI: 10.1016/j.biomaterials.2015.04.007
  • Peer Reviewed / Open Access
• [Journal Article] Oligosaccharide modification by N-acetylglucosaminyltransferase-V in macrophages are involved in pathogenesis of bleomycin-induced scleroderma. (2015)
  • Author(s): Kato A, Yutani M, Terao M, Kimura A, Itoi S, Murota H, Miyoshi E, Katayama I.
  • Journal Title: Exp Dermatol. Volume: 24 Issue: 8 Pages: 585-90
  • DOI: 10.1111/exd.12730
  • Peer Reviewed
• [Journal Article] NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation. (2015)
  • Author(s): Namiki T, Yaguchi T, Nakamura K, Valencia JC, Coelho SG, Yin L, Kawaguchi M, Vieira WD, Kaneko Y, Tanemura A, Katayama I, Yokozeki H, Kawakami Y, Hearing VJ.
  • Journal Title: Cancer Res. Volume: 75 Issue: 13 Pages: 2708-15
  • DOI: 10.1158/0008-5472.can-13-3209
  • Peer Reviewed
• [Journal Article] Th2 cytokines enhance TrkA expression, upregulate proliferation, and downregulate differentiation of keratinocytes. (2015)
  • Author(s): Matsumura S, Terao M, Murota H, Katayama I.
  • Journal Title: J Dermatol Sci. Volume: 78 Issue: 3 Pages: 215-23
  • DOI: 10.1016/j.jdermsci.2015.02.021
  • Peer Reviewed
• [Journal Article] Factors associated with the development and remission of allergic diseases in an epidemiological survey of high school students in Japan. (2015)
  • Author(s): Tokunaga T, Ninomiya T, Osawa Y, Imoto Y, Ito Y, Takabayashi T, Narita N, Kijima A, Murota H, Katayama I, Fujieda S.
  • Journal Title: Am J Rhinol Allergy. Volume: 29 Issue: 2 Pages: 94-9
  • DOI: 10.2500/ajra.2015.29.4135
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] β2-glycoprotein I/ HLA class II complexes are novel autoantigens in antiphospholipid syndrome. (2015)
  • Author(s): Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada H, Arase H.
  • Journal Title: Blood Volume: 125 Issue: 18 Pages: 2835-2844
  • DOI: 10.1182/blood-2014-08-593624
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex. (2015)
  • Author(s): Wataya-Kaneda M, Tnaka M, Yang L, Yang F, Tsuruta D, Nakamura A, Matsumoto S, Hamasaki T, Tanemura A, Katayama I
  • Journal Title: JAMA Dermatol. Volume: ? Issue: 7 Pages: 722-30
  • DOI: 10.1001/jamadermatol.2014.4298
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 4-(4-hydroroxyphenyl)-2-butanol (rhododendrol) activates the autophagy-lysosome pathway in melanocytes: insights into the mechanisms of rhododendrol-induced leukoderma (2015)
  • Author(s): Lingli Yang, .Fei Yang;、Mari Wataya-Kaneda, Atsuhi Tanemura, Daisuke Tsuruta, Ichiro Katayama
  • Journal Title: J Dermatol Sci. 2015 Mar;77(3):182-5. Volume: 77(3) Issue: 3 Pages: 182-5
  • DOI: 10.1016/j.jdermsci.2015.01.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus. (2015)
  • Author(s): Eleftheriadou V, Thomas K, van Geel N, Hamzavi I, Lim H, Suzuki T, Katayama I, Anbar T, Abdallah M, Benzekri L, Gauthier Y, Harris J, Silva de Castro CC, Pandya A, Goh BK, Lan CC, Oiso N, Al Issa A, Esmat S, Le Poole C, Lee AY, Parsad D, Taieb A, Picardo M, Ezzedine K ; Vitiligo Global Issues Consensus Group.
  • Journal Title: Pigment Cell Melanoma Res. Volume: 28 Issue: 3 Pages: 363-9
  • DOI: 10.1111/pcmr.12354
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] T helper 2 polarization in senile erythroderma with elevated levels of TARC and IgE. (2015)
  • Author(s): Nakano-Tahara M, Terao M, Nishioka M, Kitaba S, Murota H, Katayama I.
  • Journal Title: Dermatology. Volume: 230 Issue: 1 Pages: 62-9
  • DOI: 10.1159/000366502
  • Peer Reviewed
• [Journal Article] Possible association of anti-tumor necrosis factor-α antibody therapy with the development of scleroderma-like changes with lichen planus. (2015)
  • Author(s): Inoue-Nishimoto T, Hanafusa T, Igawa K, Azukizawa H, Yokomi A, Yokozeki H, Katayama I.
  • Journal Title: Eur J Dermatol. Volume: 25 Issue: 5 Pages: 513-5
  • DOI: 10.1684/ejd.2015.2631
  • Peer Reviewed
• [Journal Article] Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells. (2015)
  • Author(s): Tagami-Nagata N, Serada S, Fujimoto M, Tanemura A, Nakatsuka R, Ohkawara T, Murota H, Kishimoto T, Katayama I, Naka T.
  • Journal Title: Exp Dermatol. Volume: 24 Issue: 11 Pages: 864-71
  • DOI: 10.1111/exd.12802
  • Peer Reviewed
• [Journal Article] Case of Hermansky&#8211;Pudlak syndrome 1 in a Japanese infant (2015)
  • Author(s): Tanaka M, Yang L, Wataya-Kaneda M, Suzuki T, Okamura K, Hozumi Y, Yang F, Katayama I
  • Journal Title: J Dermatol Volume: 42 Issue: 9 Pages: 906-7
  • DOI: 10.1111/1346-8138.12937
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of additional i.v. immunoglobulin to steroid therapy in Stevens-Johnson syndrome and toxic epidermal necrolysis. (2015)
  • Author(s): Aihara M, Kano Y, Fujita H, Kambara T, Matsukura S, Katayama I, Azukizawa H, Miyachi Y, Endo Y, Asada H, Miyagawa F, Morita E, Kaneko S, Abe R, Ochiai T, Sueki H, Watanabe H, Nagao K, Aoyama Y, Sayama K, Hashimoto K, Shiohara T; SJS/TEN Study Group.
  • Journal Title: J Dermatol Volume: 42 Issue: 8 Pages: 768-777
  • DOI: 10.1111/1346-8138.12925
  • Peer Reviewed / Open Access
• [Journal Article] A rare case of mucinous carcinoma of the skin with multiple organ metastases. (2015)
  • Author(s): Tanemura A, Deguchi A, Tanaka A, Kiyohara E, Kishioka A, Katayama I.
  • Journal Title: Eur J Dermatol. Volume: 25 Issue: 5 Pages: 483-4
  • DOI: 10.1684/ejd.2015.2545
  • Peer Reviewed
• [Journal Article] Pyoderma gangrenosum and annular erythema associated with Sjogren's syndrome controlled with minocycline. (2015)
  • Author(s): Yamanaka K, Murota H, Goto H, Yamamoto S, Katayama I, Taniguchi Y, Mizutani H.
  • Journal Title: J Dermatol. Volume: 42 Issue: 8 Pages: 834-6
  • DOI: 10.1111/1346-8138.12897
  • Peer Reviewed
• [Journal Article] Possible involvement of CCR4+CD8+ T cells and elevated serum CCL22 and CCL17 in Patients with Rhododenol-induced Leukoderma. (2015)
  • Author(s): Nishioka M, Tanemura A, Yang L, Tanaka A, Arase N, Katayama I
  • Journal Title: J Dermatol Sci. Volume: 77 Issue: 3 Pages: 188-190
  • DOI: 10.1016/j.jdermsci.2015.02.014
  • Peer Reviewed / Open Access
• [Journal Article] An immune pathological and ultrastructural skin analysis for rhododenol-induced leukoderma patients. (2015)
  • Author(s): Tanemura A, Yang L, Yang F, Nagata Y, Wataya-Kaneda M, Fukai K, Tsuruta D, Ohe R, Yamakawa M, Suzuki T, Katayama I.
  • Journal Title: J Dermatol Sci. Volume: 777 Issue: 3 Pages: 185-8
  • DOI: 10.1016/j.jdermsci.2015.01.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Guide for medical professionals (i.e. dermatologists) for the management of Rhododenol-induced leukoderma. (2015)
  • Author(s): Nishigori C, Aoyama Y, Ito A, Suzuki T, Tanemura A, Ito M, Katayama I, Oiso N, Kagohashi Y, Sugiura S, Fukai K, Funasaka Y, Yamashita T, Matsunaga K.
  • Journal Title: Journal of Dermatology Volume: 42 Issue: 2 Pages: 113-128
  • DOI: 10.1111/1346-8138.12744
  • Peer Reviewed
• [Journal Article] Case of Behcet's disease complicated by oculomotor nerve palsy associated with internal carotid artery-posterior communicating artery aneurysm. (2015)
  • Author(s): Yamaoka T, Murota H, Katayama I.
  • Journal Title: J Dermatol. Volume: 42 Issue: 3 Pages: 315-7
  • DOI: 10.1111/1346-8138.12752
  • Peer Reviewed
• [Journal Article] Severe scoliosis associated with the WNT10A mutation. (2015)
  • Author(s): Koguchi-Yoshioka H, Wataya-Kaneda M, Nakano H, Tanemura A, Akasaka E, Sawamura D, Katayama I.
  • Journal Title: J Dermatol Volume: 42 Issue: 3 Pages: 322-323
  • DOI: 10.1111/1346-8138.12762
  • Peer Reviewed / Open Access
• [Journal Article] Sweat, the driving force behind normal skin: an emerging perspective on functional biology and regulatory mechanisms. (2015)
  • Author(s): Murota H, Matsui S, Ono E, Kijima A, Kikuta J, Ishii M, Katayama I.
  • Journal Title: J Dermatol Sci. Volume: 77 Issue: 1 Pages: 3-10
  • DOI: 10.1016/j.jdermsci.2014.08.011
  • Peer Reviewed
• [Journal Article] Development of necrotising fasciitis in a patient treated for rheumatoid arthritis with tocilizumab. (2015)
  • Author(s): Hashimoto N, Yamaoka T, Koguchi-Yoshioka H, Tanaka A, Tanemura A, Azukizawa H, Murota H, Kang J, Nakagawa Y, Shimazu T, Katayama I.
  • Journal Title: Acta Derm Venereol. Volume: 95 Issue: 3 Pages: 370-1
  • DOI: 10.2340/00015555-1952
  • Peer Reviewed
• [Journal Article] Atopic diathesis in hypohidrotic/anhidrotic ectodermal dysplasi (2014)
  • Author(s): Hanako Koguchi-Yoshioka1, Mari Wataya-Kaneda1#, Mizuki Yutani1, Hiroyuki Murota1, Hajime Nakano2, Daisuke Sawamura2, Ichiro Katayam
  • Journal Title: Acta Derm Venereol. Volume: ? Issue: 4 Pages: 476-479
  • DOI: 10.2340/00015555-1978
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Partial anhidrosis demonstrated by Q-SART in a patient with a novel mutation in the EDARADD gene (2014)
  • Author(s): Koguchi-Yoshioka H1, Wataya-Kaneda M1#, Yutani M1, Nakano H2, Sawamura D2, Katayama I1
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: 25 Issue: 7 Pages: 1443-9
  • DOI: 10.1111/jdv.12493
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] DIR is an innate immune sensor for microbially cleaved immunoglobulins. (2015)
  • Author(s): Kouyuki Hirayasu, Fumiji Saito, Tadahiro Suenaga, Kyoko Shida, Noriko Arase, Keita Oikawa, Toshifumi Yamaoka, Hiroyuki Murota, Hiroji Chibana, Ichiro Nakagawa, Tomoko Kubori, Hiroki Nagai, Yuji Nakamaru, Ichiro Katayama, Marco Colonna, Hisashi Arase.
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-18