Evaluation of arrhythmogenesis in patients with cardiac sarcoidosis using PET-MRI fusion images

• Project/Area Number: 15K15441
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Tamaki Nagara 北海道大学, 医学研究科, 特任教授 (30171888)
• Co-Investigator(Kenkyū-buntansha): 納谷 昌直 北海道大学, 大学病院, 講師 (20455637) ; 吉永 恵一郎 北海道大学, 医学研究科, 客員研究員 (30435961) ; 横式 尚司 北海道大学, 大学病院, 講師 (40360911) ; 真鍋 治 北海道大学, 医学研究科, 特任助教 (40443957) ; 西嶋 剣一 北海道大学, 大学病院, 薬剤師 (60364254)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 心サルコイドーシス / PET-MRI

Outline of Final Research Achievements

We established a method for semi-automatic and quantitative measurement of activity of glucose metabolism in the myocardial inflammation using FDG-PET. Evaluation of steroid treatment effect by quantitative metabolic volume (MV) revealed that 1 month of steroid treatment markedly reduced myocardial inflammation, but cardiac function improvement was not observed. Patients presenting with the acute phase of AV block are related to FDG accumulation rather than MRI delayed contrast images and may be associated with the activity of inflammation. Detailed assessment between changes in electrocardiogram findings after treatment and image inspection including FDG PET, MRI and sympathetic function is required in the future.

Research Products

• [Journal Article] Comparison of (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) and cardiac magnetic resonance (CMR) in corticosteroid-naive patients with conduction system disease due to cardiac sarcoidosis. (2016)
  • Author(s): Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, Wells GA, Yoshinaga K, Tsujino I, Sato T, Manabe O, Oyama-Manabe N, Nishimura M, Tamaki N, Dick A, Dennie C, Klein R, Renaud J, deKemp RA, Ruddy TD, Chow BJ, Davies R, Hessian R, Liu P, Beanlands RS, Nery PB.
  • Journal Title: Eur J Nucl Med Mol Imaging. Volume: 43 Issue: 2 Pages: 259-269
  • DOI: 10.1007/s00259-015-3181-8
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis. (2016)
  • Author(s): Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, Yamada A, Oyama-Manabe N, Hirata K, Nishimura M, Tamaki N.
  • Journal Title: J Nucl Cardiol Volume: 23 Issue: 2 Pages: 244-252
  • DOI: 10.1007/s12350-015-0226-0
  • NAID: 120005753717
  • Peer Reviewed / Open Access / Int'l Joint Research