| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) is accepted as the promising next generation radiotherapy. For widespread expansion of BNCT development of tumor specific boron-containing agents is required. The present research aimed to label representative boron scaffold, caroboranes, with positron emitting radionuclide, fluorine-18 which enables biodistribution examination by molecular imaging technique. We tried F-18 labeling of carboranes using electrophilic fluorinating agents starting from F-18 labeled elemental fluorine. We optimized condition of 18F-F2 production by double-irradiation method starting from 18O-O2. Optimal concentration of F2-Ar for the second irradiation was 1% as it showed good recovery of radioactivity and acceptable specific activity of radiopharmaceutical thus obtained. F-18 labeling of o-carborane was accomplished using this 18F-F2 in 21% radiochemical yield.
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