Research Project
Grant-in-Aid for Challenging Exploratory Research
X-ray and carbon ion beam (C-ion) resistant cancer cell X60 abundantly contained lysosomes, ATP, mitochondria, and reactive oxygen species. In addition, mTOR signaling, which is associated with regulation of energy production, was promoted in X60 cells. Inhibition of the mTOR signaling significantly decreased the X-ray and C-ion resistance in X60 cells. Therefore our results showed that mTOR signaling contributes the X-ray and C-ion resistance in cancer cells. Futhermore, the X60 cells were significantly resistant to plasma membrane damage which is induced by Streptolysin O treatment. Our results indicated that the X60 cells have a lot of Flottilin-1 domain on plasma membrane, which closely associated with lipid raft formation and endocytosis. Given these results, regulation of plasma membrane including lipid raft formation and endocytosis might also contribute to X-ray and C-ion resistance in cancer cells.
All 2016 2015
All Journal Article (2 results) (of which Peer Reviewed: 2 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results, Invited: 1 results)
Oncol. Rep.
Volume: 36 Issue: 5 Pages: 2946-2950
10.3892/or.2016.5122
Journal of Radiation Research
Volume: 56 Issue: 4 Pages: 633-638
10.1093/jrr/rrv015
