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Development of novel hypoxia imaging probes with a novel retention mechanism and high versatility

Research Project

Project/Area Number 15K15468
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

Umeda Izumi, O.  国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (40160791)

Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Hideyo  帝京大学, 薬学部, 教授 (10266348)
NAKAMURA Takeshi  国立がん研究センター, 先端医療開発センター・機能診断開発分野, 特任研究員 (10624611)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords低酸素 / イメージング / がん / SPECT / Tc-99m / 画像診断 / 個別化医療 / 低酸素環境 / 分子イメージング / 核医学
Outline of Final Research Achievements

Hypoxia is a characteristic feature of most solid tumors and closely related to tumor malignancy and treatment-resistance; therefore, in vivo visualization of tumor hypoxia promises to greatly contribute for optimization of cancer therapy. We herein developed new SPECT probes with a unique retention mechanism, differing from conventional nitroimidazole derivatives. In cell-based assay, our Tc-99m-labeled probes demonstrated significantly higher uptake in hypoxic cells than in normoxic cells, indicating the validity of our strategy. Animal studies revealed that their tissue distribution pattern including tumor accumulation were greatly different depending on the structure of ligand components. By modifying them, they successfully accumulated in the hypoxic region in the tumor. In vivo SPECT/CT images clearly depicted their uptake in tumors. Tc-99m is the most common nuclide for nuclear medicine probes, therefore they are quite promising as general clinical probes for hypoxia imaging.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] 新規分子設計に基づく汎用性の高い核医学低酸素可視化プローブの開発2017

    • Author(s)
      梅田 泉、木村 禎亮、藤井 博史
    • Organizer
      第15回がんとハイポキシア研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Novel SPECT Hypoxia imaging probes with unique retention mechanism.2016

    • Author(s)
      Izumi O. Umeda,Sadaaki Kimura,Hirofumi Fujii.
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine2016
    • Place of Presentation
      Balcelona International Convention Centre(Barcelona,Spain)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Newly Developed 99mTc-labeled Compact Probes Specifically Accumulated in the Tumor Hypoxia Region with Unique Retention Mechanism Differing from Conventional Nitroimidazole Derivatives2016

    • Author(s)
      Izumi O. Umeda, Sadaaki Kimura, Hirofumi Fujii
    • Organizer
      World Molecular Imaging Congress 2016
    • Place of Presentation
      The Javits Center (New York, USA)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Newly Developed 99mTc-labeled Compact Probes Specifically Accumulated in the Tumor Hypoxia Region with Unique Retention Mechanism Differing from Conventional Nitroimidazole Derivatives2016

    • Author(s)
      Izumi O. Umeda, Sadaaki Kimura, Hirofumi Fujii
    • Organizer
      World Molecular Imaging Congress 2016
    • Place of Presentation
      New York (USA)
    • Year and Date
      2016-09-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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