| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Subcutaneous islet transplantation is associated with minimal invasiveness, replicability, and ready removability, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Therefore , in the present study, we first evaluated the effectiveness of angiogenic peptide. Although rather small amount of angiogenic peptide was effective for constructing vascular network under the skin, high dose of angiogenic peptide was required in order to improve the engraftment of subcutaneous islet transplantation. Then, we focused on recombinant peptide, which includes a lot of RGD constructions. It was proved that recombinant peptide was effective for inducing vascular network under the skin, and that the outcome of subcutaneous islet transplantation using recombinant peptide was almost comparable with that of current standard intraportal islet transplantation.
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