Establishment of novel cell therapy for diabetes by introducing angiogenic peptide
Project/Area Number |
15K15469
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
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Research Institution | Tohoku University |
Principal Investigator |
Goto Masafumi 東北大学, 医学系研究科, 教授 (50400453)
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Research Collaborator |
NOKIHARA Kiyoshi
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 移植・再生医療 / 血管新生 / 膵島移植 / ペプチド |
Outline of Final Research Achievements |
Subcutaneous islet transplantation is associated with minimal invasiveness, replicability, and ready removability, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Therefore , in the present study, we first evaluated the effectiveness of angiogenic peptide. Although rather small amount of angiogenic peptide was effective for constructing vascular network under the skin, high dose of angiogenic peptide was required in order to improve the engraftment of subcutaneous islet transplantation. Then, we focused on recombinant peptide, which includes a lot of RGD constructions. It was proved that recombinant peptide was effective for inducing vascular network under the skin, and that the outcome of subcutaneous islet transplantation using recombinant peptide was almost comparable with that of current standard intraportal islet transplantation.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] The optimization of short-term hepatocyte preservation prior to transplantation2017
Author(s)
Fukuoka K, Inagaki A, Nakamura Y, Matsumura M, Yoshida S, Imura T, Igarashi Y, Miyagi S, Ohashi K, Enosawa S, Kamei T, Unno M, Ohuchi N, Satomi S, Goto M
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Journal Title
Transplantation Direct
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Supplemental Analysis for N-linked Sugars in Adult Pig Islets2016
Author(s)
Eguchi H, Kawamura T, Kashiyama N, Matsuura R, Sakai R, Nakahata K, Lo PC, Asada M, Maeda A, Goto M, Toyoda M, Okuyama H, Miyagawa S
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Journal Title
Transplantation Proc
Volume: 48
Pages: 1302-1303
Related Report
Peer Reviewed
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[Presentation] The influence of dissociation enzymes on isolated islets during pancreatic islet isolation procedures2016
Author(s)
Yuki Miyazaki, Takehiro Imura, Youhei Yamagata, Hiroshi Maeda, Kazutaka Murayama, Kimiko Watanabe, Akiko Inagaki, Yasuhiro Igarashi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
Organizer
26th International Congress of The Transplantation Society (2016)
Place of Presentation
Hong Kong (CHINA)
Year and Date
2016-08-18
Related Report
Int'l Joint Research
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