| Project/Area Number |
15K15470
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Toyoda Yu 東京大学, 医学部附属病院, 特任助教 (80650340)
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| Co-Investigator(Kenkyū-buntansha) |
高田 龍平 東京大学, 医学部附属病院, 講師 (90376468)
中川 大 中部大学, 応用生物学部, 講師 (40397039)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳がん / トランスポーター / メタボローム解析 / 乳がんリスク因子 / 乳腺外科学 |
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| Outline of Final Research Achievements |
Recently, based on an epidemiological study focusing on the patients with breast cancer in Japan, it has been pointed out that the ABCC11 wild type (WT) could be associated with the risk of breast cancer. However, it has not been well understood whether ABCC11 WT really contributes to the breast cancer risk. The aim of this study was to clear the latent relationship. Since in vivo and in vitro models are arranged as well as metabolomics technique, key molecules that are substrates for ABCC11 and could affect the nature of mammary gland should be determined in the near future.
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