The molecular mechanism of a lipid mediator involved in metabolic dynamics of breast cancer
Project/Area Number |
15K15471
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
西條 康夫 新潟大学, 医歯学系, 教授 (10270828)
小山 諭 新潟大学, 医歯学系, 教授 (10323966)
小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736)
小林 隆 新潟大学, 医歯学総合病院, 講師 (40464010)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 脂質メディエーター / スフィンゴシン-1-リン酸 / スフィンゴシンキナーゼ / 癌代謝 / メタボローム / CRISPR/Cas9 / 薬剤耐性 / 乳癌 |
Outline of Final Research Achievements |
A pleiotropic bioactive lipid mediator, sphingosine-1-phosphate (S1P), produced by sphingosine kinases (SphK1 and SphK2) regulates many physiological and pathological processes. We hypothesized that SphKs regulates cancer cell-specific metabolism, which related to the cancer cell proliferation and survival. Metabolomics profiles of both SphK1KO and SphK2KO breast cancer cells were dramatically changed in the glycolysis pathway and TCA cycle compared to the control cells. Our data suggests that SphKs play an important role in cancer specific metabolism.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice2017
Author(s)
Wang Y, Aoki H, Yang J, Peng K, Liu R, Li X, Qiang X, Sun L, Gurley EC, Lai G, Zhang L, Liang G, Nagahashi M, Takabe K, Pandak WM, Hylemon PB, Zhou H.
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Journal Title
Hepatology
Volume: 印刷中
Issue: 6
Pages: 2005-2018
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] DNA damage response and sphingolipid signaling in liver diseases2016
Author(s)
Nagahashi M, Matsuda Y, Moro K, Tsuchida J, Soma D, Hirose Y, Kobayashi T, Kosugi SI, Takabe K, Komatsu M, Wakai T
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Journal Title
Surg Today
Volume: 印刷中
Issue: 9
Pages: 995-1005
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] DNA damage response and sphingolipid signaling in liver diseases.2016
Author(s)
Masayuki Nagahashi, Yasunobu Matsuda, Kazuki Moro, Daiki Soma, Junko Tsuchida, Yuki Hirose, Takashi Kobayashi, Shin-ichi Kosugi, Kazuaki Takabe, Masaaki Komatsu, Toshifumi Wakai
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Breast Cancer Cell Metabolism Is Regulated by Sphingosine Kinases2018
Author(s)
Nagahashi M, Nakajima M, Abe M, Saito T, Komatsu M, Soga T, Tsuchida J, Yuza K, Takabe K, Sakimura K, Wakai T
Organizer
The 13th Annual Academic Surgical Congress
Related Report
Int'l Joint Research
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[Presentation] Expression of Phosphorylated Sphingosine Kinase 1 Is Associated with Invasiveness of Gastric Cancer.2017
Author(s)
Hanyu T, Ichikawa H, Ishikawa T, Kosugi S, Nakajima M, Sakata J, Kobayashi T, Kameyama H, Wakai T, Nagahashi M
Organizer
The 12th Annual Academic Surgical Congress
Place of Presentation
Las Vegas, USA
Year and Date
2017-02-07
Related Report
Int'l Joint Research
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[Presentation] Sphingosine Kinase 1 Contributes to Breast Cancer Cell Metabolism and Survival.2017
Author(s)
Nagahashi M, Nakajima M, Saito T, Komatsu M, Soga T, Zhao R, Zhou H, Okuda S, Takabe K, Wakai T
Organizer
The 12th Annual Academic Surgical Congress
Place of Presentation
Las Vegas, USA
Year and Date
2017-02-07
Related Report
Int'l Joint Research
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[Presentation] Obesity-induced Sphingosine-1-phosphate in Breast Cancer Interstitial Fluid Promotes Angiogenesis.2017
Author(s)
Tsuchida J, Nakajima M, Moro K, Ohtani A, Endo M, Niwano T, Tatsuda K, Toshikawa C, Hasegawa M, Ikarashi M, Koyama Y, Sakata J, Kobayashi T, Kameyama H, Wakai T, Takabe K, Nagahashi M
Organizer
The 12th Annual Academic Surgical Congress
Place of Presentation
Las Vegas, USA
Year and Date
2017-02-07
Related Report
Int'l Joint Research
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[Presentation] Roles of Sphingosine-1-Phosphate Produced by Sphingosine Kinases in Pancreatic Cancer Progression2017
Author(s)
Nakajima M, Miura Y, Ando T, Yuza K, Tsuchida J, Tajima Y, Abe M, Sakimura K, Wakai T, Nagahashi M
Organizer
The 12th Annual Academic Surgical Congress
Place of Presentation
Las Vegas, USA
Year and Date
2017-02-07
Related Report
Int'l Joint Research
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[Presentation] Dysregulation of Sphingolipids in Human Breast Cancer2016
Author(s)
Masayuki Nagahashi, Junko Tsuchida, Kazuki Moro, Toshiyuki Niwano, Kumiko Tatsuda, Chie Toshikawa, Miki Hasegawa, Yu Koyama, Takashi Kobayashi, Shin-ichi Kosugi, Hitoshi Kameyama, Hiroaki Aoki, Kazuaki Takabe, Toshifumi Wakai
Organizer
The 11th Annual Academic Surgical Congress
Place of Presentation
Jacksonville, USA
Year and Date
2016-02-02
Related Report
Int'l Joint Research
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[Presentation] Serum sphingosine-1-phosphate levels are elevated in breast cancer patients with lymph node metastasis2016
Author(s)
Junko Tsuchida, Masayuki Nagahashi, Kazuki Moro, Toshiyuki Niwano, Kumiko Tatsuda, Chie Toshikawa, Miki Hasegawa, Yu Koyama, Takashi Kobayashi, Shin-ichi Kosugi, Hitoshi Kameyama, Hiroaki Aoki, Kazuaki Takabe, Toshifumi Wakai
Organizer
The 11th Annual Academic Surgical Congress
Place of Presentation
Jacksonville, USA
Year and Date
2016-02-02
Related Report
Int'l Joint Research
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