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Development of arterial grafts regenerated from the xenogeneic scaffolds

Research Project

Project/Area Number 15K15477
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Kanda Keiichi  京都府立医科大学, 医学(系)研究科(研究院), 講師 (60295649)

Co-Investigator(Kenkyū-buntansha) 坂井 修  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10298432)
渡辺 太治  京都府立医科大学, 医学(系)研究科(研究院), 特任助教 (20448723)
山南 将志  京都府立医科大学, 医学部附属病院, 研究員 (30438204)
中山 泰秀  国立研究開発法人国立循環器病研究センター, その他, 研究員 (50250262)
田地川 勉  関西大学, システム理工学部, 准教授 (80351500)
Research Collaborator Yaku Hitoshi  京都府立医科大学, 医学(系)研究科(研究院), 教授 (50295648)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生体内組織工学 / 同種移植 / 異種移植 / 代用血管 / 脱細胞処理 / 自家組織 / 同種・異種移植 / 化学的修飾 / 脱細胞化処理 / 自家移植 / 小口径代用血管 / 心臓血管外科 / 小児心臓血管外科 / 生体内組織形成 / 同種・他種移植 / 細胞工学 / 心臓血管組織再生 / 架橋処理
Outline of Final Research Achievements

We applied various chemical treatments to the autologous connective tissue substitute blood vessel formed in the subcutaneous tissue of recipients and aimed at application to xenogeneic grafts. It was confirmed that glutaraldehyde, which was widely used for antigenic treatment, functioned well even with grafts of xenogeneic origin. However, since the tissue healing process tended to be slightly delayed compared to untreated autologous tissue, decellularization treatment was performed in the latter period. As a result, we were able to realize sufficient removal of antigenicity and enough strength at the same time, so we carried out xenogeneic / allogeneic animal transplant experiments. As a result, a healing process comparable to autologous tissue was revealed, suggesting the possibility of future clinical application.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results) Presentation (14 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] One year Rat Study of iBTA-induced "Microbiotube" Microvascular Grafts With an Ultra-Small Diameter of 0.6 mm.2018

    • Author(s)
      Ishii D, et al.
    • Journal Title

      Eur J Vasc Endovasc Surg.

      Volume: 13-Apr Issue: 6 Pages: 150-3

    • DOI

      10.1016/j.ejvs.2018.03.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Wall thickness control in biotubes prepared using type-C mold.2018

    • Author(s)
      Terazawa T, et al
    • Journal Title

      J Artif Organs.

      Volume: 30-Mar Issue: 3 Pages: 387-391

    • DOI

      10.1007/s10047-018-1035-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Implanted In-Body Tissue-Engineered Heart Valve Can Adapt the Histological Structure to the Environment.2018

    • Author(s)
      Takewa Y, et al.
    • Journal Title

      ASAIO J.

      Volume: May/Jun;64(3) Issue: 3 Pages: 395-405

    • DOI

      10.1097/mat.0000000000000769

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] First Successful Clinical Application of the In Vivo Tissue-Engineered Autologous Vascular Graft.2016

    • Author(s)
      Kato N, Yamagishi M, Kanda K, Miyazaki T, Maeda Y, Yamanami M, Watanabe T, Yaku H.
    • Journal Title

      Ann Thorac Surg.

      Volume: Oct;102(4) Issue: 4 Pages: 1387-90

    • DOI

      10.1016/j.athoracsur.2016.06.095

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of an in vivo tissue-engineered vascular graft with designed wall thickness (biotube type C) based on a novel caged mold.2016

    • Author(s)
      Furukoshi M, Moriwaki T, Nakayama Y.
    • Journal Title

      J Artif Organs.

      Volume: 19(1) Issue: 1 Pages: 54-61

    • DOI

      10.1007/s10047-015-0859-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 組織工学的手法で作製した脱細胞化結合組織膜の動脈パッチ移植への応用2018

    • Author(s)
      山南 将志、神田 圭一、森本 和樹、井上 知也、渡辺 太治、坂井 修、上 大介、五條 理志、夜久 均
    • Organizer
      第48回日本心臓血管外科学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脱細胞化生体由来結合組織膜の動脈パッチ移植への応用2018

    • Author(s)
      山南 将志、神田 圭一、森本 和樹、井上 知也、渡辺 太治、坂井 修、上 大介、五條 理志、夜久 均
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 異種由来自己再生型小口径代用血管『バイオチューブ・マトリックス』の開発2017

    • Author(s)
      山南 将志, 河崎 貴宣, 上 大介, 渡辺 太治, 神田 圭一, 五條 理志, 夜久 均
    • Organizer
      第16回 再生医療学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] DEVELOPMENT OF IN VIVO TISSUE ENGINEERED XENOGENEIC VASCULAR GRAFTS2017

    • Author(s)
      Yamanami M, Kawasaki T, Kami D, Watanabe T, Kanda K, Gojo S, Yaku H
    • Organizer
      The Third International Symposium on Vascular Tissue Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] First clinical application of the human Biotube to the congenital heart disease2017

    • Author(s)
      Fujita S, Yamagishi M, Yamanami M, Watanabe T, Kandan K, Yaku H
    • Organizer
      The Third International Symposium on Vascular Tissue Engineering
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Development of Xenogeneic, Self-Organizing Small-Caliber Vascular Grafts2017

    • Author(s)
      Yamanami M, Kawasaki T, Kami D, Watanabe T, Kanda K, Gojo S, Yaku H
    • Organizer
      European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2017 (TERMIS-EU 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of the xenogeneic decellularized tube matrix produced by in vivo tissue engineering to the ‘off-the-shelf’ small-caliber vascular graft2017

    • Author(s)
      Yamanami M, Kawasaki T, Kami D, Watanabe T, Kanda K, Gojo S, Yaku H
    • Organizer
      44th Annual Congress of the European Society for Artificial Organs (ESAO 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] いつでも使用可能な異種由来自己再生型小口径代用血管『バイオチューブ・マトリックス』の開発2016

    • Author(s)
      山南 将志, 河崎 貴宣, 上 大介, 渡辺 太治, 神田 圭一, 五條 理志, 夜久 均
    • Organizer
      第54回日本人工臓器学会.
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2016-11-23
    • Related Report
      2016 Research-status Report
  • [Presentation] The Development Of Xenogeneic, Self-Organizing Small-Diameter Vascular Graft2016

    • Author(s)
      Masashi Yamanami, Takanori Kawasaki, Daisuke Kami, Taiji Watanabe, Keiichi Kanda, Satoshi Gojo, Hitoshi Yaku.
    • Organizer
      ESAO 2016.
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 『バイオチューブ・マトリックス』を活用した異種由来自己再生型小口径代用血管の開発2016

    • Author(s)
      山南 将志, 河崎 貴宣, 上 大介, 渡辺 太治, 神田 圭一, 五條 理志, 夜久 均
    • Organizer
      第44回日本血管外科学会学術総会.
    • Place of Presentation
      ホテルグランパシフィック台場
    • Year and Date
      2016-05-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 新しいコンセプトに基づく生体材料の創製 Shelf Ready Graftとしての使用を目指した異種バイオチューブ小口径代用血管(XenoBiotube)の開発2015

    • Author(s)
      山南 将志, 渡辺 太治, 森本 和樹, 川尻 英長, 坂井 修, 神田 圭一, 夜久 均
    • Organizer
      第53回人工臓器学会学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] In Vivo Tissue Engineered Small Diamiter Vascular Graft; Application To Off-pump CABG In The Porcine Model.2015

    • Author(s)
      Watanabe T, Kanda K, Yamanami M, Yaku H.
    • Organizer
      American Heart Association 2015
    • Place of Presentation
      オーランド、アメリカ
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shelf Ready Graft としての使用を目指した小口径代用血管の開発:異種バイオチューブ(XenoBiotube)動物移植実験.2015

    • Author(s)
      山南 将志、渡辺 太治、川尻 英長、坂井 修、神田 圭一、夜久 均
    • Organizer
      第68回日本胸部外科学会定期学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of shelf-ready xenogeneic vascular graftDevelopment of shelf-ready xenogeneic vascular grafts; xenobiotubes.2015

    • Author(s)
      Yamanami M, Watanabe T, Kanda K, Yaku H, Nakayama Y.
    • Organizer
      European Society of Artificial Organs Annual Meeting
    • Place of Presentation
      Leuven, Belgium
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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