Exploring the role of methylation and hydroxymethylation in Hereditary Breast and Ovarian Cancer
| Project/Area Number |
15K15478
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) |
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Principal Investigator |
Yamazawa Kazuki 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医師 (10338113)
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| Co-Investigator(Kenkyū-buntansha) |
松永 達雄 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚平衡覚研究部, 部長 (90245580)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 遺伝性乳癌卵巣癌 / 遺伝性腫瘍 / メチル化 / ヒドロキシメチル化 / エピジェネティクス / 遺伝性乳がん・卵巣がん症候群 |
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| Outline of Final Research Achievements |
The novel method to analyze the distribution of methylation/hydroxymethylation in genomic DNA has been developed. Using this method, we first reported the hydroxymethylation status in congenital human imprinting disorders. Next, we have tried to analyze the blood and tumor samples derived from the hereditary tumor syndromes; however, a limited number of tumor samples and denaturation of DNA have created much difficulties in performing the analysis. It has taken more time than expected to re-collect and re-analyze human tumor samples, thus the investigation has yet to be completed. We are still conducting the analysis.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Genetic heterogeneity of patients with suspected Silver-Russell syndrome: genome-wide copy number analysis in 82 patients without imprinting defects.2017
Author(s)
Inoue T, Nakamura A, Fuke T, Yamazawa K, Sano S, Matsubara K, Mizuno S, Matsukura Y, Harashima C, Hasegawa T, Nakajima H, Tsumura K, Kizaki Z, Oka A, Ogata T, Fukami M, Kagami M.
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Journal Title
Clin Epigenetics
Volume: 9
Issue: 1
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells2016
Author(s)
Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami K, Tanaka M, Fukuda K.
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Journal Title
Stem Cell Reports
Volume: 6
Issue: 6
Pages: 825-833
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Germline whole-gene deletion and somatic nonsense variant of the CDC73 gene in a boy with primary hyperparathyroidism.2017
Author(s)
Hatabu N, Katori N, Maeda N, Suzuki E, Komiyama O, Tsutsui H, Nagao T, Sato T, Ishii T, Hasegawa T, Yamazawa K.
Organizer
日本人類遺伝学会第62回大会
Related Report
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[Presentation] CDC73遺伝子全領域を含む3.4 Mbの欠失を認めた副甲状腺腺腫の15歳男児例.2017
Author(s)
山澤一樹, 前田直則, 籏生なおみ, 香取奈穂, 鈴木絵理, 込山修, 佐藤武志, 石井智弘, 長谷川奉延, 筒井英光, 長尾俊孝.
Organizer
第23回日本家族性腫瘍学会
Related Report
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