| Project/Area Number |
15K15481
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Shimoda Masayuki 国立研究開発法人国立国際医療研究センター, その他部局等, 膵島移植プロジェクト長 (40640529)
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| Research Collaborator |
MATSUMOTO Shinichi
SHINOHARA Koya
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 臓器透明化 / 膵島移植 |
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| Outline of Final Research Achievements |
Islet transplantation has attracted attention as a treatment for unstable type 1 diabetes. It is a less invasive cell transplantation therapy and it is already a standard treatment in some countries. On the other hand, one of the drawbacks of islet transplantation is a low survival rate. It is necessary to elucidate the cause, but it is a big obstacle not to be able to observe the implanted islets directly after the portal vein injection. Therefore, by using the transparency technique of organs and a sheet laser fluorescence microscope, the whole mouse liver was visualized and the pancreatic islets were observed after transplantation while maintaining the three-dimensional structure. As a result, it was possible to verify the overall distribution of the islets, decrease of the number of islets over time. The results were announced at the international conference.
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