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Fundamental research of intraoperative nerve monitoring and sensing using magnetic utilization for thoracoscopic surgery surgery

Research Project

Project/Area Number 15K15487
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionTohoku Medical and Pharmaceutical University (2017)
Tohoku University (2015-2016)

Principal Investigator

Nakano Toru  東北医科薬科大学, 医学部, 准教授 (50451571)

Co-Investigator(Kenkyū-buntansha) 亀井 尚  東北大学, 医学系研究科, 教授 (10436115)
大内 憲明  東北大学, 医学系研究科, 客員教授 (90203710)
Research Collaborator Shimizu Kazuo  
Ujiie Naoto  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords外科 / 機能温存 / 反回神経 / 食道 / 神経 / 磁気 / 低侵襲 / 手術 / 跳躍伝導 / 低侵襲手術 / 磁界
Outline of Final Research Achievements

In order to apply intraoperative nerve monitoring method to thoracoscopic surgery for esophageal cancer, coils and magnetic sensors for magnetic nerve stimulation were fabricated for preservation of function and intraoperative nerve search. Electric and magnetic excitation conditions and electric and magnetic measurement conditions were examined using these instruments. It was necessary and possible to separately measure the electric signal of the saltatory conduction peculiar to the myelinated nerve and the electric signal conducting the surrounding tissue under non-shielding environment. It was suggested that a magnetic flux density of 0.4 T or more is required to induce nerve stimulation by magnetic flux irradiation and a response speed of 10 ms or less is required. It was also suggested that the saltately conduction would be induced by the eddy current generated by the magnetic flux generated from the coil in a short time.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Thoracoscopic primary repair with mediastinal drainage is a viable option for patients with Boerhaave’s syndrome2018

    • Author(s)
      Nakano Toru、Onodera Ko、Ichikawa Hirofumi、Kamei Takashi、Taniyama Yusuke、Sakurai Tadashi、Miyata Go
    • Journal Title

      Journal of Thoracic Disease

      Volume: 10 Issue: 2 Pages: 784-789

    • DOI

      10.21037/jtd.2018.01.50

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma2017

    • Author(s)
      Onodera Y, Nakano T, Takeyama D, Maruyama, Taniyama Y, Sakurai , Heishi T, Sato C, Kumagai T and Kamei T
    • Journal Title

      World Journal of Gastroenterology

      Volume: 23(46) Pages: 8256-8260

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors for delayed oral dietary intake in patients with deep neck infections including descending necrotizing mediastinitis.2017

    • Author(s)
      Hidaka H, Ozawa D, Kuriyama S, Obara T, Nakano T, Kakuta R, Nomura K, Watanabe K, Katori Y.
    • Journal Title

      Eur Arch Otolaryngol.

      Volume: 274 Issue: 11 Pages: 3951-3958

    • DOI

      10.1007/s00405-017-4716-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful corticosteroid treatment for pleural effusion due to radiation-induced pleuritis after chemoradiotherapy in a patient with esophageal cancer2017

    • Author(s)
      Kumagai Takuro、Nakano Toru、Matsushita Haruo、Jingu Keiichi、Ohuchi Noriaki、Kamei Takashi
    • Journal Title

      International Cancer Conference Journal

      Volume: 6 Issue: 3 Pages: 138-143

    • DOI

      10.1007/s13691-017-0293-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bilateral approach for thoracoscopic esophagectomy with lymph node dissection in the dorsal area of the thoracic aorta in patients with esophageal cancer: A report of two cases2017

    • Author(s)
      Onodera Yu、Nakano Toru、Heishi Takahiro、Sakurai Tadashi、Taniyama Yusuke、Sato Chiaki、Ohuchi Noriaki、Kamei Takashi
    • Journal Title

      International Journal of Surgical Case Report

      Volume: 31 Pages: 154-158

    • DOI

      10.1016/j.ijscr.2017.01.040

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thoracoscopic surgery in the prone position for esophageal cancer in patients with situs inversus totalis: A report of two cases2017

    • Author(s)
      Nakano Toru、Kamei Takashi、Onodera Yu、Ujiie Naoto、Ohuchi Noriaki
    • Journal Title

      International Journal of Surgical Case Report

      Volume: 31 Pages: 43-46

    • DOI

      10.1016/j.ijscr.2017.01.009

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of routine recurrent laryngeal nerve monitoring in prone esophagectomy with mediastinal lymph node dissection. Surgical Endoscopy2016

    • Author(s)
      Hikage M, Kamei T, Nakano T, Shigeo A, Katsura K, Taniyama Y, Sakurai T, Teshima J, Ito S, Niizuma N, Hiroshi Okamoto H, Fukutomi T, Masato Yamada M, Shota Maruyama S Noriaki Ohuchi N.
    • Journal Title

      Surgical Endoscopy

      Volume: 8 Issue: 7 Pages: 2986-2996

    • DOI

      10.1007/s00464-016-5317-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thoracoscopic esophageal repair with barbed suture material in a case of Boerhaave’s syndrome.2016

    • Author(s)
      Nakano T, Chiaki Sato C, Sakurai T, Kamiya K, Kamei T, and Ohuchi N
    • Journal Title

      Journal Thoracic Disease

      Volume: - Issue: 12 Pages: 1572-1580

    • DOI

      10.21037/jtd.2016.12.46

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A laser-induced pulsed water jet for layer-selective submucosal dissection of the esophagus2016

    • Author(s)
      Nakano T, Sato C, Masato Y,Yamamoto H, Fujishima F, Tominaga T, Nakagawa A, Satomi S, Ohuchi N.
    • Journal Title

      LASER THERAPY

      Volume: 25 Issue: 3 Pages: 185-191

    • DOI

      10.5978/islsm.16-OR-14

    • NAID

      130005598506

    • ISSN
      0898-5901, 1884-7269
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of a newly developed piezo actuator-driveb pulsed water jet system for liver resection in a surviving swine model.2016

    • Author(s)
      Nakanishi C, Nakano T, Nakagawa A, Sato C, Yamada M, Kawagishi N, Tomonaga T, Ohuchi N
    • Journal Title

      BioMedical Engineering OnLine

      Volume: 15 Issue: 1 Pages: 9-9

    • DOI

      10.1186/s12938-016-0126-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 食道癌サルベージ手術のリンパ節郭清と安全性に施行するための工夫2018

    • Author(s)
      中野 徹, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 佐藤 千晃, 岡本 宏史, 小野寺 優, 武山 大輔, 亀井 尚
    • Organizer
      日本消化管学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当科における胸腔鏡下食道切除術の手術手技と治療成績2017

    • Author(s)
      櫻井 直, 中野 徹, 谷山 裕亮, 瓶子 隆弘, 武山 大輔, 佐藤 千晃, 丸山 祥太, 今野 卓朗, 小関 健, 亀井 尚
    • Organizer
      72回 日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食道癌に対する縦隔リンパ節郭清の手術手技 腹臥位胸腔鏡下食道切除術における縦隔リンパ節郭清手技 助手の役割と合併症予防対策2017

    • Author(s)
      中野 徹, 櫻井 直, 谷山 裕亮, 瓶子 隆弘, 武山 大輔, 丸山 祥太, 今野 卓朗, 小関 健, 亀井 尚
    • Organizer
      72回 日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢cStageII/III胸部食道癌患者に対する治療の現況と展望.日本食道学会学術集会プログラム2017

    • Author(s)
      氏家 直人, 谷山 裕亮, 中野 徹, 櫻井 直, 瓶子 隆弘, 武山 大輔, 佐藤 千晃, 丸山 祥太, 亀井 尚
    • Organizer
      71回 日本食道学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食道癌に対する根治的化学放射線治療後の胸腔鏡下サルベージ手術における局所制御と周術期の工夫2017

    • Author(s)
      中野 徹, 谷山 裕亮, 櫻井 直, 瓶子 隆弘, 武山 大輔, 丸山 祥太, 今野 卓朗, 小野寺 優, 亀井 尚
    • Organizer
      71回 日本食道学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胸腔鏡下食道切除術における術中反回神経モニタリングとその工夫2016

    • Author(s)
      中野 徹、亀井 尚、櫻井 直、谷山 裕亮、武山 大輔、佐藤 千晃、久保田 洋介、神谷 蔵人、
    • Organizer
      日本内視鏡外科学会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行食道癌における副損傷回避のための胸腔鏡下手術手技~大血管、気道からの剥離操作2016

    • Author(s)
      亀井 尚,中野 徹,谷山 祐亮,櫻井 直,武山 大輔,瓶子 隆弘,佐藤 千晃,大内 憲明..
    • Organizer
      第78回日本臨床外科学会 2016.11.24-26 ,2016.
    • Place of Presentation
      東京都品川区、高輪プリンスホテル
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 道癌術後合併症の診断と治療 新しい工夫 食道癌術後合併症の低減を目的とした術中反回神経モニタリングと神経機能温存予測2015

    • Author(s)
      日景 允, 亀井 尚, 中野 徹, 谷山 裕亮, 櫻井 直, 手島 仁, 岡本 宏史, 福富 俊明, 伊藤 想一, 新妻 展近
    • Organizer
      日本食道学会
    • Place of Presentation
      横浜 パシフィコ横浜
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 臨床用補助器具2018

    • Inventor(s)
      中野徹、日景允
    • Industrial Property Rights Holder
      中野徹、日景允
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-12-27  

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