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Search of organ specific tumor markers by N-glycan expression in pancreatic cancer

Research Project

Project/Area Number 15K15501
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

Natsugoe Shoji  鹿児島大学, 医歯学域医学系, 教授 (70237577)

Co-Investigator(Kenkyū-buntansha) 又木 雄弘  鹿児島大学, 医歯学域附属病院, 特任講師 (10444902)
前村 公成  鹿児島大学, 医歯学域医学系, 准教授 (30398292)
内門 泰斗  鹿児島大学, 医歯学域附属病院, 特任准教授 (30464465)
上之園 芳一  鹿児島大学, 医歯学総合研究科, 特任准教授 (60398279)
橋口 照人  鹿児島大学, 医歯学域医学系, 教授 (70250917)
蔵原 弘  鹿児島大学, 医歯学域医学系, 助教 (70464469)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵臓癌 / N型糖鎖 / 腫瘍マーカー
Outline of Final Research Achievements

We analyzed the serum N-glycan in 17 pancreatic cancer patients and 11 healthy volunteers. N-glycan expression by using OPLS method was stratified between pancreatic cancer patients and healthy volunteers on the base of glycan expression pattern. We extracted six N-glycan with statistical significance between pancreatic cancer patients and healthy volunteers. According to these six markers, four markers was ascertained by duplication test. These results show that these N-glycan may be a useful markers in early detection of pancreatic cancer and relapse disease.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Radiotherapy for metastatic lesion of pancreatic cancer2015

    • Author(s)
      Maemura K, Mataki Y, Kurahara H, Shinchi H, Natsugoe S.
    • Journal Title

      Nihon Rinsho

      Volume: 73 Pages: 163-167

    • Related Report
      2015 Research-status Report
  • [Journal Article] Assessment of percutaneous laparoscopic ultrasonography-guided core needle biopsy for the advanced diagnosis of unresectable pancreatic cancer.2015

    • Author(s)
      Maemura K, Shinchi H, Mataki Y, Kurahara H, Iino S, Sakoda M, Ueno S, Takao S, Natsugoe S.
    • Journal Title

      JOP.

      Volume: 16 Pages: 45-49

    • DOI

      10.6092/1590-8577/2891

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prognostication by inflammation-based score in patients with locally advanced pancreatic cancer treated with chemoradiotherapy2015

    • Author(s)
      Hiroshi Kurahara
    • Journal Title

      Pancreatology

      Volume: 15 Issue: 6 Pages: 688-693

    • DOI

      10.1016/j.pan.2015.09.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 局所進行膵癌に対する化学放射線療法の効果予測因子2015

    • Author(s)
      蔵原 弘,夏越祥次
    • Organizer
      第70回日本消化器外科学会
    • Place of Presentation
      アクトシティ浜松浜松市
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 切除不能局所進行膵癌に対する化学放射線療法2015

    • Author(s)
      蔵原 弘,夏越祥次
    • Organizer
      第46回日本膵臓学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 切除症例からみた膵癌に対する術前化学放射線療法および術前化学療法2015

    • Author(s)
      蔵原 弘,夏越祥次
    • Organizer
      第115回日本外科学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] N結合型糖鎖を利用した消化器癌の検査方法2016

    • Inventor(s)
      鹿児島大学 住友ベークライト
    • Industrial Property Rights Holder
      鹿児島大学 住友ベークライト
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-04-06
    • Acquisition Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
    • Overseas

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Published: 2015-04-16   Modified: 2018-03-22  

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