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Searching the potential factor(s) of regulating endogenous regeneration in infarcted heart of mice

Research Project

Project/Area Number 15K15509
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionNagasaki University

Principal Investigator

LI Tao-Sheng  長崎大学, 原爆後障害医療研究所, 教授 (50379997)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords心筋再生 / 因子 / 心臓再生 / 再生ニッチ / 心筋幹細胞 / 心筋梗塞
Outline of Final Research Achievements

By focusing on the kinetic changes of cytokines/chemokines and extracellular matrix/adhesion molecules after myocardial infarction, we tried to search the potential factor(s) of regulating endogenous regeneration in heart. We ligated the left anterior descending artery in healthy mice, and then collected heart tissues from infarct area, border area, and remote area at 1, 3, 7 and 14 days, respectively. RT2 ProfilerTM PCR array analysis showed that many genes were up- or down-regulated over 2-fold in each area during the 14 days following-up. Interestingly, the number of up- and down-regulated genes encoding cytokines/chemokines and extracellular matrix/adhesion molecules tended to decrease in the border area but not in the infarct area with time after MI. Further experiments are required to identify the key factor(s) involving in the regenerative process of heart after injury.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 9 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (1 results)

  • [Int'l Joint Research] NC State University(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future2018

    • Author(s)
      Tang Jun-Nan、Cores Jhon、Huang Ke、Cui Xiao-Lin、Luo Lan、Zhang Jin-Ying、Li Tao-Sheng、Qian Li、Cheng Ke
    • Journal Title

      STEM CELLS Translational Medicine

      Volume: 7 Issue: 4 Pages: 354-359

    • DOI

      10.1002/sctm.17-0196

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] abrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice.2017

    • Author(s)
      Luo L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li TS, Cheng K.
    • Journal Title

      Circulation Research

      Volume: 印刷中 Issue: 11 Pages: 1768-1775

    • DOI

      10.1161/circresaha.116.310374

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome2017

    • Author(s)
      Tang Junnan、Shen Deliang、Caranasos Thomas George、Wang Zegen、Vandergriff Adam C.、Allen Tyler A.、Hensley Michael Taylor、Dinh Phuong-Uyen、Cores Jhon、Li Tao-Sheng、Zhang Jinying、Kan Quancheng、Cheng Ke
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 13724-13724

    • DOI

      10.1038/ncomms13724

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ionizing radiation impairs endogenous regeneration of infarcted heart: an in vivo 18F-FDG PET/CT and 99mTc-tetrofosmin SPECT/CT study in mice.2017

    • Author(s)
      Luo L, Nishi K, Urata Y, Yan C, Hasan AS, Goto S, Kudo T, Li ZL, Li TS
    • Journal Title

      Radiation Research

      Volume: 187 Issue: 1 Pages: 89-97

    • DOI

      10.1667/rr14543.1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment.2016

    • Author(s)
      Hasan AS, Luo L, Yan C, Zhang TX, Urata Y, Goto S, Mangoura SA, Abdel-Raheem MH, Zhang S, Li TS.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 10 Pages: e0165255-e0165255

    • DOI

      10.1371/journal.pone.0165255

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver2016

    • Author(s)
      Shuai Zhang, Tao-Sheng Li, Akihiko Soyama, Takayuki Tanaka, Chen Yan, Yusuke Sakai, Masaaki Hidaka, Ayaka Kinoshita, Koji Natsuda, Mio Fujii, Tota Kugiyama, Zhassulan Baimakhanov, Tamotsu Kuroki, Weili Gu, Susumu Eguchi
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 26540-26540

    • DOI

      10.1038/srep26540

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair.2016

    • Author(s)
      Shen D, Tang J, Hensley MT, Li T, Caranasos TG, Zhang T, Zhang J, Cheng K.
    • Journal Title

      Stem Cells Transl Med.

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of aging on the quantity and quality of human cardiac stem cells.2016

    • Author(s)
      Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, Ueno K, Nishimoto A, Kurazumi H, Suzuki R, Ito H, Sakata K, Mikamo A, Li TS, Hamano K.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 22781-22781

    • DOI

      10.1038/srep22781

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Time- and dose-dependent effects of total-body ionising radiation on muscle stem cells2015

    • Author(s)
      Masuda S, Hisamatsu T, Seko S, Urata Y, Goto S, Li TS & Ono Y
    • Journal Title

      Physiol Rep

      Volume: 3(4) Issue: 4 Pages: e12377-e12377

    • DOI

      10.14814/phy2.12377

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Searching the potential factor(s) of regulating endogenous regeneration in infarcted heart of mice2018

    • Author(s)
      Lan Luo, Yoshishige Urata, Chen Yan, Shinji Goto, Tao-Sheng Li
    • Organizer
      第17回日本再生医療学会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2022-06-07  

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