Searching the potential factor(s) of regulating endogenous regeneration in infarcted heart of mice
Project/Area Number |
15K15509
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular surgery
|
Research Institution | Nagasaki University |
Principal Investigator |
LI Tao-Sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 心筋再生 / 因子 / 心臓再生 / 再生ニッチ / 心筋幹細胞 / 心筋梗塞 |
Outline of Final Research Achievements |
By focusing on the kinetic changes of cytokines/chemokines and extracellular matrix/adhesion molecules after myocardial infarction, we tried to search the potential factor(s) of regulating endogenous regeneration in heart. We ligated the left anterior descending artery in healthy mice, and then collected heart tissues from infarct area, border area, and remote area at 1, 3, 7 and 14 days, respectively. RT2 ProfilerTM PCR array analysis showed that many genes were up- or down-regulated over 2-fold in each area during the 14 days following-up. Interestingly, the number of up- and down-regulated genes encoding cytokines/chemokines and extracellular matrix/adhesion molecules tended to decrease in the border area but not in the infarct area with time after MI. Further experiments are required to identify the key factor(s) involving in the regenerative process of heart after injury.
|
Report
(4 results)
Research Products
(11 results)
-
-
-
-
-
-
-
[Journal Article] Up-regulated extracellular matrix components and inflammatory chemokines may impair the regeneration of cholestatic liver2016
Author(s)
Shuai Zhang, Tao-Sheng Li, Akihiko Soyama, Takayuki Tanaka, Chen Yan, Yusuke Sakai, Masaaki Hidaka, Ayaka Kinoshita, Koji Natsuda, Mio Fujii, Tota Kugiyama, Zhassulan Baimakhanov, Tamotsu Kuroki, Weili Gu, Susumu Eguchi
-
Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 26540-26540
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
[Journal Article] Influence of aging on the quantity and quality of human cardiac stem cells.2016
Author(s)
Nakamura T, Hosoyama T, Kawamura D, Takeuchi Y, Tanaka Y, Samura M, Ueno K, Nishimoto A, Kurazumi H, Suzuki R, Ito H, Sakata K, Mikamo A, Li TS, Hamano K.
-
Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 22781-22781
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-