| Project/Area Number |
15K15516
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
CHEN Fengshi 京都大学, 医学研究科, 講師 (00452334)
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| Co-Investigator(Kenkyū-buntansha) |
伊達 洋至 京都大学, 医学研究科, 教授 (60252962)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HLA抗体 / 肺移植 / 血液型不適合 / 生体肺移植 / クロスマッチ陽性 / 血液型抗原 / 抗体関連型拒絶 |
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| Outline of Final Research Achievements |
Recently, the importance of donor-specific anti-HLA antibodies (DSAs) has been pointed out in lung transplantation. We investigated various characteristics of DSAs in living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT). Anti-HLA antibodies have been prospectively screened periodically in 134 patients undergoing lung transplantation. Anti-HLA antibodies were screened in 64 patients with LDLLT and 70 patients with CLT before and after lung transplantation. Postoperatively, 17 patients (13%) had de novo DSAs. There were 3 patients in LDLLT (5%) and 14 patients in CLT (20%, p=0.001). In LDLLT, DSAs vanished in 1 out of 3 patients, while, in CLT, DSAs were detected within 3 months postoperatively in 10 out of 14 patients (p=0.12). We confirmed that de novo DSAs were detected less frequently in LDLLT than in CLT.
Furthermore, we investigated chimerism of the lungs using injured lungs after hematopoieticstem cell transplantation.
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