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Development of programs to predict and to maximize QOL after epilepsy surgery

Research Project

Project/Area Number 15K15521
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

Nakasato Nobukazu  東北大学, 医学系研究科, 教授 (80207753)

Co-Investigator(Kenkyū-buntansha) 藤川 真由  東北大学, 大学病院, 助教 (80722371)
岩崎 真樹  国立研究開発法人国立精神・神経医療研究センター, 病院, 部長 (00420018)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsてんかん / 心理社会的評価 / 脳神経外科 / 患者教育 / セルフスティグマ / 就労支援 / 外科治療 / 生活の質 / てんかん外科 / 抑うつ / 不安 / 抗てんかん薬
Outline of Final Research Achievements

Roughly one million people suffer with epilepsy in Japan. Surgical treatment may be considered in about 30% of the patients in whom antiepileptic drugs are not able to control seizures. Previously, seizure outcome was used to evaluate efficacy of epilepsy surgery. Recently, however, overall satisfaction level of patients and their family has been used to evaluate rationale of surgery. In the present project, quality of life (QOL) was used to evaluate efficacy of epilepsy surgery. Under the process to develop programs to predict and to maximize QOL after epilepsy surgery, we found patients’ self-stigma, job-condition and individual-based patient education were important to improve the post-operative QOL.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Int'l Joint Research: 5 results,  Invited: 7 results) Book (2 results)

  • [Journal Article] てんかん患者の就労支援における医療の役割2017

    • Author(s)
      藤川真由,岩城弘隆,大竹茜,柿坂庸介,北澤悠,神一敬,中里信和
    • Journal Title

      職業リハビリテーション

      Volume: 31 Pages: 3-9

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 成人てんかん患者における病状説明と心理社会的要因の関連2017

    • Author(s)
      小川舞美,藤川真由,岩城弘隆,北澤悠,柿坂庸介,神一敬,中里信和,上埜高志
    • Journal Title

      東北大学大学院教育学研究科臨床心理相談室紀要

      Volume: 15 Pages: 25-38

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 寝言とみなされていた発作時発話の1例2017

    • Author(s)
      鈴木健大、柿坂庸介、北澤悠、神一敬、佐藤志帆、岩崎真樹、藤川真由、西尾慶之、菅野彰剛、中里信和
    • Journal Title

      Brain and Nerve

      Volume: 69 Pages: 167-171

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fantastic confabulation in right frontal lobe epilepsy2016

    • Author(s)
      Fujikawa M, Nishio Y, Kakisaka Y, Ogawa N, Iwasaki M, Nakasato N.
    • Journal Title

      Epilepsy Behav Case Rep

      Volume: 6 Pages: 55-57

    • DOI

      10.1016/j.ebcr.2016.08.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Verbal Dominant Memory Impairment and Low Risk for Post-operative Memory Worsening in Both Left and Right Temporal Lobe Epilepsy Associated with Hippocampal Sclerosis2016

    • Author(s)
      Khalil AF, Iwasaki M, Nishio Y, Jin K, Nakasato N, Tominaga T
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 56 Issue: 11 Pages: 716-723

    • DOI

      10.2176/nmc.oa.2016-0004

    • NAID

      130005282106

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epilepsy case with focal cerebral herniation into the sigmoid sinus.2016

    • Author(s)
      Kakisaka Y, Sato S, Takayanagi M, Nakasato N
    • Journal Title

      Neurol Sci

      Volume: 37 Issue: 3 Pages: 487-488

    • DOI

      10.1007/s10072-015-2430-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] High frequency oscillations are less frequent but more specific to epileptogenicity during rapid eye movement sleep.2016

    • Author(s)
      Sakuraba R, Iwasaki M, Okumura E, Jin K, Kakisaka Y, Kato K, Tominaga T, Nakasato N
    • Journal Title

      Clin Neurophysiol

      Volume: 127 Issue: 1 Pages: 179-186

    • DOI

      10.1016/j.clinph.2015.05.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The current state of epilepsy guidelines: A systematic review2016

    • Author(s)
      Sauro KM, Wiebe S, Dunkley C, Janszky J, Kumlien E, Moshe S, Nakasato N, Pedley TA, Perucca E, Senties H, Thomas SV, Wang Y, Wilmshurst J, Jette N
    • Journal Title

      Epilepsia

      Volume: 57 Issue: 1 Pages: 13-23

    • DOI

      10.1111/epi.13273

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical profiles for seizure remission and developmental gains after total corpus callosotomy.2016

    • Author(s)
      Iwasaki M, Uematsu M, Hino-Fukuyo N, Osawa SI, Shimoda Y, Jin K, Nakasato N, Tominaga T
    • Journal Title

      Brain Dev

      Volume: 38 Issue: 1 Pages: 47-53

    • DOI

      10.1016/j.braindev.2015.04.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Resection of focal cortical dysplasia located in the upper pre-central gyrus.2015

    • Author(s)
      Eldin SS, Iwasaki M, Nishio Y, Jin K, Nakasato N, Tominaga T
    • Journal Title

      Epileptic Disord

      Volume: 17 Issue: 4 Pages: 479-484

    • DOI

      10.1684/epd.2015.0771

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] てんかんリハビリテーション2017

    • Author(s)
      藤川真由
    • Organizer
      山形てんかん講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 入院精査後に心因性非てんかん発作が消えた思春期3例2017

    • Author(s)
      藤川真由,北澤悠,加藤量広,柿坂庸介,岩城弘隆,神一敬,中里信和
    • Organizer
      第15回東北てんかんフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] リハビリテーションにおける心理社会的スクリーニングの有用性2017

    • Author(s)
      藤川真由
    • Organizer
      第52回東北・北海道肢体不自由児施設療育担当職員研修会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] てんかんん診療における心理社会的アプローチ2017

    • Author(s)
      藤川真由,小川舞美,中里信和
    • Organizer
      第51回てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 日本語版Epilepsy Stigma Scaleの作成とその信頼性および妥当性の検討2017

    • Author(s)
      小川舞美,藤川真由,岩城弘隆,植田和,北澤悠,柿坂庸介,神一敬,上埜高志,中里信和
    • Organizer
      第51回てんかん学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] てんかん患者におけるセルフスティグマの予測因子の検討2017

    • Author(s)
      小川舞美,藤川真由,岩城弘隆,北澤悠,柿坂庸介,神一敬,中里信和,上埜高志
    • Organizer
      全国てんかんセンター協議会総会
    • Place of Presentation
      奈良市、奈良春日野国際フォーラム
    • Related Report
      2016 Research-status Report
  • [Presentation] てんかん患者の社会復帰における心理士の実践的アプローチ2017

    • Author(s)
      藤川真由,上埜高志,中里信和
    • Organizer
      全国てんかんセンター協議会総会
    • Place of Presentation
      奈良市、奈良春日野国際フォーラム
    • Related Report
      2016 Research-status Report
  • [Presentation] てんかん症例の心理社会的側面2016

    • Author(s)
      藤川真由
    • Organizer
      宮城県言語聴覚士会高次脳機能障害部会研修会
    • Place of Presentation
      仙台(東北労災病院)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Predictors and inhibitors of weight loss during topiramate treatment for epilepsy2016

    • Author(s)
      Iwaki H, Fujikawa M, Jin K, Kaneko S, Nakasato N
    • Organizer
      70th American Epilepsy Society Annual Meeting
    • Place of Presentation
      George R. Brown Convention Center, Houston, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Epilepsy-related perceived stigma in relation to seizure-related and psychosocial factors among adults with epilepsy2016

    • Author(s)
      Ogawa M, Fujikawa M, Iwaki H, Kitazawa Y, Kakisaka Y, Jin K, Ueno T, Nakasato N
    • Organizer
      70th American Epilepsy Society Annual Meeting
    • Place of Presentation
      George R. Brown Convention Center, Houston, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] linical decision-making in candidates for epilepsy surgery with psychogenic nonepileptic seizures: three case reports2016

    • Author(s)
      Taniguchi G, Kunii N, Okamura Y, Nishimura R, Fujikawa M, Jin K, Nakasato N
    • Organizer
      70th American Epilepsy Society Annual Meeting
    • Place of Presentation
      George R. Brown Convention Center, Houston, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] てんかん患者支援におけるソーシャルワーカーの視点と役割2016

    • Author(s)
      小川舞美,藤川真由,岩城隆弘,上埜高志,中里信和
    • Organizer
      第6回全国てんかんリハビリテーション研究会
    • Place of Presentation
      久留米市、久留米大学医学部教育1号館
    • Related Report
      2016 Research-status Report
  • [Presentation] 病状説明がてんかん患者の心理社会面に及ぼす影響2016

    • Author(s)
      小川舞美,藤川真由,岩城弘隆,北澤悠,柿坂庸介,神一敬,中里信和,上埜高志
    • Organizer
      第50回日本てんかん学会学術集会
    • Place of Presentation
      静岡市 グランシップ静岡
    • Related Report
      2016 Research-status Report
  • [Presentation] Predictors of quality of life and social functioning among adults with temporal lobe epilepsy.2015

    • Author(s)
      Fujikawa M, Nishio Y, Iwaki H, Kitazawa Y, Kato K, Kakisaka Y, Iwasaki M, Jin K, Nakasato N
    • Organizer
      69th American Epilepsy Society Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-12-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] てんかんリハビリテーションのコンセプト2015

    • Author(s)
      藤川真由
    • Organizer
      第49回日本てんかん学会学術集会
    • Place of Presentation
      長崎(長崎ブリックホール、他)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Epilepsy knowledge is the key towards social acceptance among university students in Japan2015

    • Author(s)
      Fujikawa M, Kaneko N, Ueno T, Kakisaka Y, Iwaki H, Jin K, Iwasaki M, Kato K, Kitazawa Y, Nakasato N
    • Organizer
      31st International Epilepsy Congress
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] てんかんをもつ中高生のQuality of Lifeに関する研究2015

    • Author(s)
      岸本百合,藤川真由,岩城弘隆,加藤量広,柿坂庸介,岩崎真樹,神一敬,上埜高志,中里信和
    • Organizer
      第9回日本てんかん学会東北地方会
    • Place of Presentation
      仙台(江陽グランドホテル)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Diagnostic performance and utility of the Child Behavior Checklist DSM-oriented scales in epilepsy2015

    • Author(s)
      Fujikawa M, Jones JE, Kakisaka Y, Nakasato N
    • Organizer
      第57回日本小児神経学会学術集会
    • Place of Presentation
      大阪(帝国ホテル)
    • Year and Date
      2015-05-30
    • Related Report
      2015 Research-status Report
  • [Book] ねころんで読めるてんかん診療2016

    • Author(s)
      中里信和
    • Total Pages
      200
    • Publisher
      メディカ出版
    • Related Report
      2015 Research-status Report
  • [Book] 「てんかん」のことがよくわかる本2015

    • Author(s)
      中里信和
    • Total Pages
      98
    • Publisher
      講談社
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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