| Project/Area Number |
15K15522
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA MASASHI 山形大学, 医学部, 講師 (70512614)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | glioma-initiating cell / 神経膠芽腫 |
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| Outline of Final Research Achievements |
Glucose metabolism is often increased in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism contributes to the maintenance of glioma stem cells through the modulation of intracellular ROS levels as well as to investigate the mechanism underlying the increase in intracellular ROS levels caused by impaired glucose metabolism via GLUT1 inhibition. While the results of this study supported the idea that increase in intracellular ROS levels leads to loss of stem cell properties, the molecular mechanism of ROS increase following GLUT1 inhibition remains to be shown.
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