| Project/Area Number |
15K15526
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
荒川 芳輝 京都大学, 医学研究科, 特定講師 (20378649)
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| Co-Investigator(Renkei-kenkyūsha) |
Matsuda Fumihiko 京都大学, 医学研究科, 教授 (50212220)
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| Research Collaborator |
Tsuruyama Tatsuaki 京都大学, 医学研究科, 准教授 (60437332)
kuyama hiroki
Fujimoto Ko-ichi
Liu Bin
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 松果体実質性腫瘍 / ｐineal parenchymal tumor / 分子メカニズム / molecular mechanism / pinealocyte / 悪性転化 / Pineal parenchymal tumor / ホルマリン固定パラフィン包埋組織 / FFPE / ゲノムワイド変異解析 / 多層的腫瘍オミックス解析 / 質量分析 |
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| Outline of Final Research Achievements |
Pineal parenchymal tumor is a rare tumor deriving from pinealocyte and molecular mechanisms of its oncogenesis and malignant transformation remain unclear. In this study, we have analyzed molecular mechanism in pineal parenchymal tumor using formalin fixed paraffin embedded (FFPE) tumors. Expression of chromogranin A could be a prognostic maker better than thatt of neurofilament. Expression of somatostatin type2 (SSTR2) is increased, but did not have significant relationship with clinical result, other neuronal maker and malignancy.
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