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Novel in vivo optical imaging method monitoring oxidative stress

Research Project

Project/Area Number 15K15527
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionOkayama University

Principal Investigator

Abe Koji  岡山大学, 医歯薬学総合研究科, 教授 (20212540)

Co-Investigator(Kenkyū-buntansha) 山下 徹  岡山大学, 医歯薬学総合研究科, 講師 (60644408)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsin vivo イメージング / 脳梗塞 / Keap1 / Nrf2 / 酸化ストレスセンサー / 中大脳動脈閉塞モデル / NRF2 / 酸化ストレス / 一過性中大脳動脈閉塞
Outline of Final Research Achievements

We investigated the time-dependent change of in vivo optical imaging of oxidative stress after stroke with OKD mice. The in vivo signals showed a peak at 1 d after tMCAO that was slightly correlated to infarct volume. The strong ex vivo signals, which were detected in the peri-ischemic area, corresponded to endogenous Nrf2 expression.
Our result of synchronization between in vivo imaging and endogenous Nrf2 expression might provide a benefit to verification of drugs targeting the Nrf2-mediated defense pathway and the therapeutic time window in acute phase of ischemic stroke.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 10 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Time-dependent change of in vivo optical imaging of oxidative stress in a mouse stroke model.2017

    • Author(s)
      Nakano Y, Yamashita T, Li Q, Sato K, Ohta Y, Morihara R, Hishikawa N, Abe K.
    • Journal Title

      J Neurosci Res.

      Volume: 印刷中 Issue: 10 Pages: 2030-2039

    • DOI

      10.1002/jnr.24047

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.2017

    • Author(s)
      Kusaki M, Ohta Y, Inufusa H, Yamashita T, Morihara R, Nakano Y, Liu X, Shang J, Tian F, Fukui Y, Sato K, Takemoto M, Hishikawa N, Abe K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 印刷中 Issue: 6 Pages: 1191-1196

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.01.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2.2016

    • Author(s)
      Morihara R, Yamashita T, Kono S, Shang J, Nakano Y, Sato K, Hishikawa N, Ohta Y, Heitmeier S, Perzborn E, Abe K.
    • Journal Title

      J Neurosci Res.

      Volume: 印刷中 Issue: 9 Pages: 1818-1828

    • DOI

      10.1002/jnr.24013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dynamic mislocalizations of nuclear pore complex proteins after focal cerebral ischemia in rat.2016

    • Author(s)
      Li Q, Ohta Y, Yamashita T, Shang J, Deguchi K, Feng T, Sato K, Hishikawa N, Nakano Y, Abe K.
    • Journal Title

      J Neurosci Res.

      Volume: 印刷中 Issue: 9 Pages: 1745-1759

    • DOI

      10.1002/jnr.24005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain.2016

    • Author(s)
      Li Q, Nakano Y, Shang J, Ohta Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Abe K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: Oct;25(10): Issue: 10 Pages: 2344-2351

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.05.031

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Recent Progress in Therapeutic Strategies for Ischemic Stroke.2016

    • Author(s)
      Yamashita T, Abe K.
    • Journal Title

      Cell Transplant.

      Volume: 25 Issue: 5 Pages: 893-8

    • DOI

      10.3727/096368916x690548

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.2015

    • Author(s)
      Liu W, Yamashita T, Kurata T, Kono S, Hishikawa N, Deguchi K, Zhai Y, Abe K.
    • Journal Title

      Neurol Res.

      Volume: 37 Issue: 6 Pages: 491-501

    • DOI

      10.1179/1743132815y.0000000002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High Incidence of Dementia Conversion than Stroke Recurrence in Poststroke Patients of Late Elder Society.2015

    • Author(s)
      Nakano Y, Deguchi K, Yamashita T, Morihara R, Matsuzono K, Kawahara Y, Sato K, Kono S, Hishikawa N, Ohta Y, Higashi Y, Takao Y, Abe K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 24 Issue: 7 Pages: 1621-8

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.03.037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Telmisartan promotes potential glucose homeostasis in stroke-resistant spontaneously hypertensive rats via peroxisome proliferator-activated receptor γ activation.2015

    • Author(s)
      Omote Y, Deguchi K, Kurata T, Yamashita T, Sato K, Hishikawa N, Abe K.
    • Journal Title

      Curr Neurovasc Res.

      Volume: 12 Pages: 91-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke.2015

    • Author(s)
      Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, Deguchi K, Abe K.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 24 Issue: 3 Pages: 537-47

    • DOI

      10.1016/j.jstrokecerebrovasdis.2014.09.037

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ラット一過性脳虚血モデルにおけるTDP43とFUS/TLSの発現亢進による神経細胞保護効果について2016

    • Author(s)
      中野由美子、孫淼、山下徹、森原隆太、太田康之、阿部康二
    • Organizer
      第59回日本脳循環代謝学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] ivaroxaban and Apixaban Reduce Hemorrhagic Complication by Protection of Neurovascular Unit after Thrombolysis in Ischemic Stroke of Rat2016

    • Author(s)
      Morihara R, Kono S, Yamashita T, and Abe K
    • Organizer
      The 9th International Symposium on Neuroprotection Neurorepair 2016
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2016-04-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel cell transplantation therapy for stroke using induced neural stem cells2016

    • Author(s)
      Yamashita T, Morihara R and Abe K
    • Organizer
      The 9th International Symposium on Neuroprotection Neurorepair 2016
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2016-04-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Thrombolysis with Tissue Plasminogen Activator 3-4.5h after Acute Ischemic Stroke in 5 Hospital Groups in Japan2015

    • Author(s)
      Morihara R, Kono S, Nakano Y, Yamashita T, Manabe Y, Takao Y, Kashihara K,
    • Organizer
      Asia Pacific Stroke Conference 2015
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] High incidence of dementia conversion than stroke recurrence in post-stroke patients of late elder society2015

    • Author(s)
      Nakano Y, Deguchi K, Yamashita T, Morihara R, Sato K, Hishikawa N, Ohta Y, Higashi Y, Takao Y, and Abe K
    • Organizer
      The 3rd Asian Clinical Conference (ACC3)
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Strong improvement of ApoE/LDL-R signals by telmisartan in post-stroke SHR-SR2015

    • Author(s)
      Yamashita T, Zhai Y, Hishikawa N, Ohta Y, Abe K
    • Organizer
      The 3rd Asian Clinical Conference (ACC3)
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2015-09-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vivo optical imaging in post-stroke mice model treated with bone marrow stromal cells or edaravone2015

    • Author(s)
      Yamashita T, Tian F, Deguchi K, Ohta Y, Hishikawa N, Abe K
    • Organizer
      The 9th International Conference on Complex Medical Engineering 2015 (CME2015)
    • Place of Presentation
      Tokyo, JAPAN
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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