Examination of association between glioma stem cell generation and driver gene mutations identified in lower grade gliomas

• Project/Area Number: 15K15534
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
• Principal Investigator: KANEMURA Yonehiro 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 先進医療研究開発部 再生医療研究室, 室長 (80344175)
• Co-Investigator(Kenkyū-buntansha): 正札 智子 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 先進医療研究開発部 幹細胞医療研究室, 室長 (40450895)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 低悪性度グリオーマ / iPS細胞 / 神経前駆細胞 / Tet-onシステム / ドライバー遺伝子変異

Outline of Final Research Achievements

We introduced driver gene mutations identified in lower grade gliomas (LGG) into human iPS cells using Tet-on system, and established human iPS cells derived neural progenitor cells (hiPSC-NPC) with BRAF-V600E mutation. BRAF-V600E mutation promoted cellular proliferative ability of hiPSC-NPC, and up-regulation of MAPK/PI3K/RAS pathway associated genes were involved with this gene effect. There are very few reports to do functional analysis of LGG associated driver gene mutations using hiPSC and hiPSC-NPC. It is concluded we achieved to obtain a novel and exploratory findings in the related scientific filed.

Research Products

• [Journal Article] Brain Tumors Using Amino Acid Transport PET Imaging with (18)F-fluciclovine: A Comparative Study with L-methyl-(11)C-methionine PET Imaging. (2017)
  • Author(s): Tsuyuguchi N, Terakawa Y, Uda T, Nakajo K, Kanemura Y.
  • Journal Title: Asia Ocean J Nucl Med Biol Volume: 5 Pages: 85-94
  • Peer Reviewed / Open Access
• [Journal Article] Mouse Models of Glioblastoma (2017)
  • Author(s): Kijima N, Kanemura Y.
  • Journal Title: Glioblastoma [Internet] Volume: chapter7 Pages: 131-139
  • DOI: 10.15586/codon.glioblastoma.2017.ch7
  • ISBN: 9780994438126
  • Open Access
• [Journal Article] Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor. (2017)
  • Author(s): Iwata R, Maruyama M, Ito T, Nakano Y, Kanemura Y, Koike T, Oe S, Yoshimura K, Nonaka M, Nomura S, Sugimoto T, Yamada H, Asai A.
  • Journal Title: Med Mol Morphol Volume: 50(4) Issue: 4 Pages: 211-219
  • DOI: 10.1007/s00795-017-0160-0
  • Peer Reviewed / Open Access
• [Journal Article] Enchondromatosis-associated oligodendroglioma: case report and literature review (2017)
  • Author(s): Achiha Takamune、Arita Hideyuki、Kagawa Naoki、Murase Tsuyoshi、Ikeda Jun-ichiro、Morii Eiichi、Kanemura Yonehiro、Fujimoto Yasunori、Kishima Haruhiko
  • Journal Title: Brain Tumor Pathology Volume: 35 Issue: 1 Pages: 36-40
  • DOI: 10.1007/s10014-017-0303-y
  • Peer Reviewed / Open Access
• [Journal Article] Radiomicsによる大規模臨床データを利用した脳腫瘍の画像分子診断の試み (2017)
  • Author(s): 木下 学、金村米博
  • Journal Title: INNERVISION Volume: 32 Pages: 38-40
• [Journal Article] The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants (2017)
  • Author(s): Pajtler KW, Kanemura Y（36名中12番目）, Taylor MD, et al.
  • Journal Title: Acta Neuropathol Volume: 133 Issue: 1 Pages: 5-12
  • DOI: 10.1007/s00401-016-1643-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas (2017)
  • Author(s): Fukushima S, Yamashita S, Kobayashi H, et al.; Intracranial Germ Cell Tumor Genome Analysis Consortium (The iGCTConsortium).
  • Journal Title: Acta Neuropathologica Volume: 133 Issue: 3 Pages: 445-462
  • DOI: 10.1007/s00401-017-1673-2
  • Peer Reviewed / Open Access
• [Journal Article] A case of pilocytic astrocytoma requiring tumor resection during pregnancy (2016)
  • Author(s): Umehara T, Okita Y, Nonaka M, Kanemura Y, Kodama Y, Mano M, Nakajima S, Fujinaka T.
  • Journal Title: Mol Clin Oncol Volume: 4 Issue: 4 Pages: 567-570
  • DOI: 10.3892/mco.2016.773
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy (2016)
  • Author(s): Ichimura K, Fukushima S, Nagane M, The Intracranial Berm Cell Tumor Genome Analysis Consortium, et al
  • Journal Title: Acta Neuropathol Volume: Published online: 08 March Issue: 6 Pages: 889-901
  • DOI: 10.1007/s00401-016-1557-x
  • Peer Reviewed
• [Journal Article] Rapid regression of glioblastoma following carmustine wafer implantation: A case report (2016)
  • Author(s): Fukai J, Nishibayashi H, Uematsu Y, Kanemura Y, Fujita K, Nakao N.
  • Journal Title: Mol Clin Oncol Volume: 5 Issue: 1 Pages: 153-157
  • DOI: 10.3892/mco.2016.894
  • Peer Reviewed / Open Access
• [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas (2016)
  • Author(s): Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
  • Journal Title: Acta Neuropathol Commun. Volume: 4 Issue: 1 Pages: 79
  • DOI: 10.1186/s40478-016-0351-2
  • Peer Reviewed / Open Access
• [Journal Article] Health-related quality of life in outpatients with primary central nervous system lymphoma after radiotherapy and high-dose methotrexate chemotherapy. (2016)
  • Author(s): Okita Y, Narita Y,
  • Journal Title: Molecular and Clinical Oncology Volume: 5 Issue: 3 Pages: 179-185
  • DOI: 10.3892/mco.2016.962
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas. (2016)
  • Author(s): Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y.
  • Journal Title: PLoS One Volume: 11 Issue: 10 Pages: e0164268-e0164268
  • DOI: 10.1371/journal.pone.0164268
  • Peer Reviewed / Open Access
• [Journal Article] Molecular Classification of Medulloblastoma (2016)
  • Author(s): Kijima N, Kanemura Y.
  • Journal Title: Neurologia medico-chirurgica Volume: 56 Issue: 11 Pages: 687-697
  • DOI: 10.2176/nmc.ra.2016-0016
  • NAID: 130005282102
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report (2016)
  • Author(s): Ishibashi K, Inoue T, Fukushima H, Watanabe Y, Iwai Y, Sakamoto H, Yamasaki K, Hara J, Shofuda T, Kanematsu D, Yoshioka E, Kanemura Y.
  • Journal Title: Childs Nerv Syst Volume: 32 Issue: 12 Pages: 2433-2438
  • DOI: 10.1007/s00381-016-3161-8
  • Peer Reviewed
• [Journal Article] Different intellectual outcomes in molecular subgroups of medulloblastoma (2016)
  • Author(s): Kijima N, Kanemura Y.
  • Journal Title: Transl Cancer Res Volume: 5 Issue: S7 Pages: S1311-S1314
  • DOI: 10.21037/tcr.2016.12.65
  • Peer Reviewed / Open Access
• [Journal Article] 家族性腫瘍（遺伝性腫瘍症候群） (2016)
  • Author(s): 金村米博
  • Journal Title: 第4版 EBMに基づく脳神経疾患の基本治療指針 Volume: - Pages: 197-209
• [Journal Article] 髄芽腫に対する遺伝子診断 (2016)
  • Author(s): 金村米博
  • Journal Title: 脳神経外科診療プラクティス7 グリオーマ治療のDecision Making Volume: - Pages: 268-271
• [Journal Article] 脳腫瘍の分子生物学：概論 (2016)
  • Author(s): 金村米博
  • Journal Title: 脳腫瘍学－基礎研究と臨床研究の進歩－日本臨牀74巻 増刊号7 Volume: 74 Pages: 103-111
• [Journal Article] 悪性神経膠腫に対するインターフェロンの有用性 (2016)
  • Author(s): 沖田典子、成田善孝、金村米博
  • Journal Title: 脳腫瘍学－基礎研究と臨床研究の進歩－日本臨牀74巻 増刊号7 Volume: 74 Pages: 695-698
• [Journal Article] Therapeutic Strategies for Medulloblastoma based on its Molecular and Genetic Diagnosis (2016)
  • Author(s): 金村米博
  • Journal Title: Japanese Journal of Neurosurgery Volume: 25 Issue: 4 Pages: 307-314
  • DOI: 10.7887/jcns.25.307
  • NAID: 130005149004
  • ISSN: 0917-950X, 2187-3100
• [Journal Article] Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas. (2016)
  • Author(s): Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.
  • Journal Title: AJNR Am J Neuroradiol Volume: 37 Issue: 1 Pages: 44-50
  • DOI: 10.3174/ajnr.a4460
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. (2015)
  • Author(s): Okita Y, Nonaka M, Umehara T, Kanemura Y, Kodama Y, Mano M, Nakajima S.
  • Journal Title: Oncol Lett Volume: 9 Issue: 4 Pages: 1885-1888
  • DOI: 10.3892/ol.2015.2940
  • Peer Reviewed / Open Access
• [Journal Article] Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage (2015)
  • Author(s): Umehara T, Okita Y, Nonaka M, Mori K, Kanemura Y, Kodama Y, Mano M, Kudawara I, Nakajima S.
  • Journal Title: Internal Medicine Volume: 54 Issue: 10 Pages: 1297-1302
  • DOI: 10.2169/internalmedicine.54.3560
  • NAID: 130005069791
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Human Chorionic Gonadotropin is Expressed Virtually in All Intracranial Germ Cell Tumors. (2015)
  • Author(s): Takami H, Fukushima S, Fukuoka K, Suzuki T, Yanagisawa T, Matsushita Y, Nakamura T, Arita H, Mukasa A, Saito N, Kanamori M, Kumabe T, Tominaga T, Kobayashi K, Nagane M, Iuchi T, et al.
  • Journal Title: J Neurooncol Volume: 124 Issue: 1 Pages: 23-32
  • DOI: 10.1007/s11060-015-1809-y
  • Peer Reviewed
• [Presentation] Radionomic analysis of WHO grade 2 and 3 gliomas with genetic subgroup prediction. (2017)
  • Author(s): Kinoshita M, Arita H, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Kodama Y, Mori K, Ichimura k, Kanemura Y.
  • Organizer: 22nd Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Int'l Joint Research
• [Presentation] Glioblastoma treatment of Bevacizumab era in Kansai region, Japan. (2017)
  • Author(s): Mori K, Shofuda T, Okita Y, Arita H, Kinoshita M, Terakawa Y, Tsuyuguchi N, Tomogane Y, Fukai J, Ishibashi K, Nishida N, Taki T, Nonaka M, Izumoto S, Moriuchi S, Nakajima Y, Hashimoto N, Kodama Y, Hirose T, Kanemura Y.
  • Organizer: 22nd Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Int'l Joint Research
• [Presentation] Characterization of patient-derived tumor spheres and xenografts for glioblastoma. (2017)
  • Author(s): Kijima N, Kanematsu D, Shofuda T, Yoshioka E, Handa Y, Moriuchi S, Nonaka M, Okita Y, Tsuyuguchi N, Fukai J, Higuchi Y, Suemizu H, Kanemura Y.
  • Organizer: 22nd Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Int'l Joint Research
• [Presentation] TERT promoter status refines the prognostication of IDH wt gliomas. (2017)
  • Author(s): Arita H, Yamasaki K, Mukasa A, Kanemura Y, Nagene M, Ueki K, Nishikawa R, Komori T, Narita Y, Ichimura K.
  • Organizer: 第35回日本脳腫瘍病理学会
• [Presentation] 大規模脳腫瘍画像データの網羅的な解析を目指した Radiomics解析の開発． (2017)
  • Author(s): 木下 学, 有田英之, 佐々木貴浩, 藤田浩二, 高橋雅道, 成田善孝, 金村米博, 貴島晴彦.
  • Organizer: 一般社団法人日本脳神経外科学会第76回学術総会
• [Presentation] 国内大規模画像コホートを用いた人工知能によるGradeII-III神経膠種の画像分子診断． (2017)
  • Author(s): 木下 学，福間良平，柳澤琢史，篠崎隆志，貴島晴彦，高橋雅道，成田善孝，有田英之，藤本康倫，寺川雄三，露口尚弘，深井順也，沖田典子，高垣匡寿，石橋謙一，児玉良典，埜中正博，森内秀祐，泉本修一，中島義和，森 鑑二，正札智子，市村幸一，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] 母と子に発症した神経膠芽腫の病理組織像と分子遺伝学的検討． (2017)
  • Author(s): 香川尚己, 阿知波孝宗, 横田千里, 有田英之, 藤本康倫, 貴島晴彦, 森井英一, 金村米博, 中里洋一, 吉峰俊樹.
  • Organizer: 第35回日本脳腫瘍病理学会
• [Presentation] 多発性内軟骨腫(Ollier病)に合併した乏突起膠腫の一例． (2017)
  • Author(s): 阿知波孝宗, 有田英之, 横田千里, 福 章悟, 香川尚己, 村瀬 剛, 池田純一郎, 森井英一, 金村米博, 藤本康倫.
  • Organizer: 第35回日本脳腫瘍病理学会
• [Presentation] 高齢者神経膠腫の分子マーカーと予後、治療選択：関西中枢神経腫瘍分子診断ネットワークに登録された142例の解析． (2017)
  • Author(s): 深井順也, 佐々木貴浩, 金村米博, 森 鑑二, 正札智子, 兼松大介, 吉岡絵麻, 児玉良典, 上松右二, 中尾直之.
  • Organizer: 第35回日本脳腫瘍病理学会
• [Presentation] 神経膠腫の非造影病変での定位的評価によるmethionine PETとMGMTプロモーターメチル化率の相関牲について． (2017)
  • Author(s): 沖田典子, 正札智子, 兼松大介, 吉岡絵麻, 児玉良典, 眞能正幸, 木下 学, 埜中正博, 中島 伸, 金村米博, 藤中俊之.
  • Organizer: 一般社団法人日本脳神経外科学会第76回学術総会
• [Presentation] 高齢者神経膠腫の臨床・病理像：関西中枢神経腫瘍分子診断ネットワークに登録された142例の後方視的解析． (2017)
  • Author(s): 深井順也, 佐々木貴浩, 金村米博, 森 鑑二, 正札智子, 兼松大介, 吉岡絵麻, 児玉良典, 廣瀬隆則, 藤田浩二, 上松右二, 中尾直之.
  • Organizer: 一般社団法人日本脳神経外科学会第76回学術総会
• [Presentation] 当科におけるグリオーマIntegrated diagnosisの現状． (2017)
  • Author(s): 上松右二, 深井順也, 金村米博, 西林宏起, 藤田浩二, 中尾直之.
  • Organizer: 一般社団法人日本脳神経外科学会第76回学術総会
• [Presentation] グリオーマ初代培養確立株の特徴とそのin vivoでの形態の特徴についての検討． (2017)
  • Author(s): 木嶋教行，兼松大介，正札智子，吉岡絵麻，半田有佳子，森内秀祐，埜中正博，沖田典子，露口尚弘，深井順也，樋口裕一郎，末水洋志，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] 神経膠腫の非造影病変での定位的評価によるMET-PETとMGMTメチル化率の相関性． (2017)
  • Author(s): 沖田典子，正札智子，兼松大介，吉岡絵麻，児玉良典，眞能正幸，木下 学，埜中正博，中島 伸，金村米博，藤中俊之.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] gliomaの遺伝子変異とMethionine-PETの相関性について． (2017)
  • Author(s): 露口尚弘，寺川雄三，宇田武弘，木下 学，有田英之，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] MGMTプロモーター領域のメチル化予測を目指した膠芽腫のRadiomics解析． (2017)
  • Author(s): 佐々木貴浩，木下 学，藤田浩二，有田英之，宇田武弘，露口尚弘，林 宣秀，深井順也，上松右二，森 鑑二，沖田典子，埜中正博，森内秀祐，中尾直之，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] Lower Grade GliomaのRadiogenomic解析． (2017)
  • Author(s): 有田英之，木下 学，川口 淳，児玉良典，高橋雅道，寺川雄三，沖田典子，高垣匡寿，深井順也，石橋謙一，露口尚弘，森内秀祐，泉本修一，中島義和，藤田浩二，埜中正博，藤本康倫，森 鑑二，正札智子，成田善孝，市村幸一，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] 関西中枢神経系腫瘍分子診断ネットワークにおけるベバシズマブ時代の膠芽腫治療． (2017)
  • Author(s): 森 鑑二，正札智子，兼松大介，吉岡絵麻，沖田典子，有田英之，木下 学，宇田武弘，友金祐介，深井順也，石橋謙一，西田南海子，瀧 琢有，埜中正博，泉本修一，中島義和，森内秀祐，露口尚弘，寺川雄三，橋本直哉，児玉良典，廣瀬隆則，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] Grade II-III神経膠腫再発／悪性転化に対するベバシズマブの治療成績の検討． (2017)
  • Author(s): 梅原 徹，有田英之，金村米博，香川尚己，藤本康倫，貴島晴彦.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] 高齢者神経膠腫の臨床・病理像：関西中枢神経腫瘍分子診断ネットワーク登録症例の解析． (2017)
  • Author(s): 深井順也，佐々木貴浩，正札智子，兼松大介，吉岡絵麻，児玉良典，廣瀬隆則，沖田典子，友金祐介，木下 学，泉本修一，有田英之，森内秀祐，露口尚弘，寺川雄三，宇田武弘，中島義和，西田南海子，埜中正博，石橋謙一，藤田浩二，上松右二，中尾直之，森 鑑二，金村米博.
  • Organizer: 第35回日本脳腫瘍学会学術集会
• [Presentation] ：関西中枢神経腫瘍分子診断ネットワークの活動報告． (2017)
  • Author(s): 森 鑑二，沖田典子，有田英之，木下 学，宇田武弘，友金祐介，深井順也，石橋謙一，西田南海子，瀧 琢有，埜中正博，泉本修一，中島義和，児玉良典，橋本直哉，金村米博.
  • Organizer: Neurosurgery Kinki 2017 Spring Meeting 第73回日本脳神経外科学会近畿支部学術集会 第75回近畿脊髄外科研究会 合同開催
• [Presentation] グリオーマにおける化学療法感受性の遺伝子指標の探索とそれに基づくテーラーメイド治療法の開発． (2017)
  • Author(s): 金村米博.
  • Organizer: 探索医療薬物研究会第5回合同シンポジウム『がんと創薬－基礎研究と臨床応用の接点』
• [Presentation] 脳腫瘍の分子遺伝学 (2017)
  • Author(s): 金村米博
  • Organizer: 第76回日本病理学会近畿支部学術集会
  • Place of Presentation: 高槻市
  • Invited
• [Presentation] ACTIVITY REPORT OF A REGIONAL MOLECULAR DIAGNOSTIC NETWORK FOR CENTRAL NERVOUS SYSTEM (CNS) TUMORS IN JAPAN (2016)
  • Author(s): Mori K, Shofuda T, Okita Y, Arita H, Kinoshita M, Terakawa Y, Tsuyuguchi N, Tomogane Y, Fukai J, Ishibashi K, Nishida N, Taki T, Nonaka M, Izumoto S, Moriuchi S, Nakajima Y, Hashimoto N, Kodama Y, Kanemura Y.
  • Organizer: 21st Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Place of Presentation: Scottsdale, Arizona, USA
  • Int'l Joint Research
• [Presentation] TERT PROMOTER MUTATION IS A POOR PROGNOSTIC MARKER FOR GBMS AND INTERACTS WITH MGMT METHYLATION STATUS (2016)
  • Author(s): Arita H, Yamasaki K, Nakamura T, Shirahata M, Kobayashi K, Tamura K, Fukai J, Terakawa Y, Mori K, Nakamura H, Yoshimoto K, Kanemura Y, Mukasa A, Nagane M, Ueki K, Komori T, Nishikawa R, Narita Y, Ichimura K.
  • Organizer: 21st Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Place of Presentation: Scottsdale, Arizona, USA
  • Int'l Joint Research
• [Presentation] IMPACT OF GENETIC ALTERATIONS ON TUMOR LOCATIONS AND LESION HETEROGENEITY FOR WHO GRADE 2 AND 3 GLIOMAS: A VOXEL-BASED LESION MAPPING AND IMAGE TEXTURE ANALYSIS OF 201 GLIOMAS (2016)
  • Author(s): Kinoshita M, Arita H, Yoshimine T, Takahashi M, Narita Y, Terakawa Y, Tsuyuguchi N, Okita Y, Nonaka M, Moriuchi S, Fukai J, Izumoto S, Ishibashi K, Nakajima Y, Takagaki M, Shofuda T, Kodama Y, Mori K, Ichimura K, Kanemura Y.
  • Organizer: 21st Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
  • Place of Presentation: Scottsdale, Arizona, USA
  • Int'l Joint Research
• [Presentation] Grade II-III 神経膠腫の遺伝子変異と発生部位：国内大規模コホートRadiogenomics解析 (2016)
  • Author(s): 有田英之、木下 学、高橋雅道、寺川雄三、沖田典子、高垣匡寿、深井順也、石橋謙一、児玉良典、埜中正博、露口尚弘、森内秀祐、泉本修一、中島義和、正札智子、成田善孝、市村幸一、森 鑑二、藤本康倫、金村米博
  • Organizer: 第34回日本脳腫瘍学会学術集会
  • Place of Presentation: 甲府市
• [Presentation] CRISPR/Cas9-mediated targeted insertion of a safety switch in an extragenic safe harbor of induced pluripotent stem cells. (2015)
  • Author(s): Kimura Y, Kanemura Y, Shofuda T, Onodera M, Oda M, Nakamori M, Nakano T, Mochizuki H.
  • Organizer: 第21回日本遺伝子治療学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2015-07-25
• [Presentation] 小児脳腫瘍の遺伝子解析 (2015)
  • Author(s): 金村米博
  • Organizer: 第20回脳腫瘍レビュー
  • Place of Presentation: 東京都港区
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] ラブドイド・グリオブラストーマの臨床・病理学的検討：自験例報告と文献的考察 (2015)
  • Author(s): 深井順也、上松右二、金村米博、正札智子、吉岡絵麻、兼松大介、藤田浩二、中尾直之
  • Organizer: 第33回日本脳腫瘍病理学会
  • Place of Presentation: 高松市
  • Year and Date: 2015-05-29
• [Presentation] 妊娠を契機に増大し手術加療を要したPilocytic astrocytomaの一例 (2015)
  • Author(s): 梅原 徹、沖田典子、埜中正博、山田修平、中西克彦、黒田淳子、金村米博、児玉良典、中島 伸、藤中俊之
  • Organizer: Neurosurgery Kinki 2015 Spring Meeting 第69回日本脳神経外科学会近畿支部学術集会・第71回近畿脊髄外科研究会合同開催
  • Place of Presentation: 豊中市
  • Year and Date: 2015-04-18