| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
For both basic research and clinical applications, it is very important to prevent dedifferentiation of chondrocytes. Therefore, in this study I have performed a comprehensive analysis of the molecular mechanisms that control the dedifferentiation of chondrocytes using Swarm rat chondrosarcoma chondrocytes. Although the mechanisms are still unclear, I have established a new experimental system to specifically and efficiently induce the chondrocyte dedifferentiation by a retrovirus vector. So, by determining the retrovirus insertion sites, we will be able to elucidate the molecular mechanism of the dedifferentiation.
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