| Project/Area Number |
15K15540
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Shinohara Masahiro 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60345733)
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| Co-Investigator(Kenkyū-buntansha) |
中浜 健一 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (60281515)
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| Research Collaborator |
KODA Naoki
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 骨粗鬆症 / 骨代謝 / 骨細胞 / 骨芽細胞 / 骨形成 / PI3K |
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| Outline of Final Research Achievements |
Osteoporosis is a disease with a high risk of bone fracture, in which bone mass decreases owing to various factors such as ageing. Since currently there is no method or drug for osteoporosis therapy to stimulate bone formation, the aim of this study is to establish a molecular basis for a novel strategy of regulating the stimulation of bone formation through understanding a mechanism of bone formation mediated by osteoblasts.
Based on the analysis of mice, in which the PI3K gene is ablated specifically in osteocytes that regulate bone homeostasis, we revealed a novel mechanism by which osteocytes regulate osteoblastic bone formation. The results in this study will lead to develop a novel strategy for osteoporosis therapy by stimulation of bone formation in the future.
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