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The role of xanthin oxydase in the etiology of osteoarthritis

Research Project

Project/Area Number 15K15541
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ASOU Yoshinori  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (50345279)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords変形性関節症 / メタボリックシンドローム / 尿酸 / キサンチンオキシダーゼ / 尿酸代謝 / 高脂肪食 / 変形性膝関節症 / 膝蓋下脂肪体 / キサンチンオキシドリダクターゼ
Outline of Final Research Achievements

A metabolic syndrome (MetS) is accompanied by hyperuricemia, during which xanthine oxidoreductase (XOR) catalyzes the production of uric acid. In the cohort study, a correlation between uric acid concentration in the synovial fluid and osteoarthritis (OA) incidence is observed. The purpose of our study was to elucidate XOR function in terms of correlation between MetS and OA. Mice were fed normal diet (ND) or high fat diet (HFD) with or without febuxostat (FEB), a XOR inhibitor. HFD stimulated XOR activity in the IPFP and the visceral fat. OA changes had progressed due to HFD, but these changes were reduced upon FEB administration. IL-1β expression in the HFD group was increased in accordance with the enhancement of NLRP3 or iNOS expression in the infrapatellar fat pad (IPFP), whereas it was inhibited by FEB administration. Based on the above results, we showed that inflammasome activation accompanied by an increase in XOR activity contributed to IFP inflammation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Intraoperative evaluation of the effects of femoral component offset and head size on joint stability in total hip arthroplasty2017

    • Author(s)
      Jinno Tetsuya、Koga Daisuke、Asou Yoshinori、Morita Sadao、Okawa Atsushi、Muneta Takeshi
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 25 Issue: 1

    • DOI

      10.1177/2309499016684298

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine oxidoreductase activation is implicated in the onset of metabolic arthritis.2016

    • Author(s)
      Aibibula Z, Ailixiding M, Iwata M, Piao J, Hara Y, Okawa A, Asou Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 472 Issue: 1 Pages: 26-32

    • DOI

      10.1016/j.bbrc.2016.02.039

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pleiotropic Functions of High Fat Diet in the Etiology of Osteoarthritis.2016

    • Author(s)
      Asou Y, Iwata M, Ochi H, Ailixiding M, Aibibula Z, Piao J, Jin G, Hara Y, Okawa A.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 9 Pages: e0162794-e0162794

    • DOI

      10.1371/journal.pone.0162794

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 新規PAI-1阻害剤はマウス骨髄除去モデルにおいて骨形成を促進する2017

    • Author(s)
      Aobulikasimu Alkebaier, 金 光文, 朴 金瑛, Zulipiya Aibibula, 段 孝, 市村 敦彦, 宮田 敏男, 越智 広樹, 佐藤 信吾, 大川 淳, 麻生 義則
    • Organizer
      日本整形外科基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規PAI-1阻害薬は閉経後骨粗鬆症モデルの骨密度を回復させる2017

    • Author(s)
      金 光文, 朴 英瑛, Aobulikasimu Alkebaier, Zulipiya Aibibula, 段 孝, 市村 敦彦, 赤堀 浩司, 宮田 敏男, 越智 広樹, 佐藤 信吾, 大川 淳, 麻生 義則
    • Organizer
      日本整形外科基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高脂肪食誘導性変形性膝関節症におけるキサンチンオキシダーゼ(XOR)の機能解析2016

    • Author(s)
      Zulipiya Aibibula、Maierhaba Ailixiding、朴 金瑛,  金光文、古賀 大介, 大川 淳、 麻生 義則
    • Organizer
      日本整形外科基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡県 福岡市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Xanthine oxidase inhibitor febuxostat attenuate high fat diet-induced osteoarthritis.2016

    • Author(s)
      Zulipiya Aibibula*2, Maierhaba Ailixiding*1, Jinying Piao2 , Daisuke Koga2, Atsushi Okawa2, Yoshinori Asou2
    • Organizer
      annual meeting of Orthopaedic Research Society
    • Place of Presentation
      フロリダ州オーランド(米国)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高脂肪食誘導性変形性膝関節症におけるキサンチンオキシダーゼ(XOR)の機能解析2015

    • Author(s)
      麻生 義則, Zulipiya Aibibula, Maierhaba Ailixiding, 朴 金瑛, 金 光文, 古賀 大介, 大川 淳
    • Organizer
      日本整形外科基礎学会)
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] メタボリックOAにおけるキサンチンオキシダーゼの機能解析2015

    • Author(s)
      ゾリビア アビブラ1)、マルハバ アルシデン2)、朴金瑛1)、金光文1)、大川淳1)、麻生義則
    • Organizer
      東京骨関節フォーラム
    • Place of Presentation
      昭和大学(東京都品川区)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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