Research Project
Grant-in-Aid for Challenging Exploratory Research
The purpose of this study was to clarify the regulatory mechanism of the bone derived brain regulating factor. Firstly, we generated the bone specific membrane protein deficient (CKO) mice and analyzed. CKO mice showed dwarfism via low serum GH and IGF-1, and then low bone mass caused by decrease of osteoblast differentiation. Furthermore, matured osteoblast derived factors inhibited the GH expression on a GH3 pituitary cell line. These findings in this study indicates that bone regulates GH secretion in pituitary. We are now trying to clarify the molecular mechanism on the regulation of GH secretion by bone-derived factors.
All 2017 2016 2015 2014
All Journal Article (10 results) (of which Int'l Joint Research: 5 results, Peer Reviewed: 10 results, Open Access: 5 results, Acknowledgement Compliant: 3 results)
J Bone Miner Res.
Volume: 32 Issue: 4 Pages: 872-881
10.1002/jbmr.3053
EBioMedicine
Volume: 18 Pages: 118-27
10.1016/j.ebiom.2017.03.011
PLoS One.
Volume: 11 Issue: 9 Pages: e0162794-e0162794
10.1371/journal.pone.0162794
Volume: - Issue: 7 Pages: 1344-1355
10.1002/jbmr.2803
Volume: -
Mol Metab
Volume: 4 Issue: 3 Pages: 175-185
10.1016/j.molmet.2015.01.002
FEBS Lett.
Volume: 589 Issue: 21 Pages: 3302-8
10.1016/j.febslet.2015.09.024
Biomed Res Int.
Volume: 2015 Pages: 730105-730105
10.1155/2015/730105
Domest Anim Endocrinol.
Volume: - Pages: 126-133
10.1016/j.domaniend.2015.09.004
Gerontology
Volume: - Issue: 4 Pages: 319-26
10.1159/000366419