Titanium fiber paper for compound fracture repair, bone tissue regeneration and enthesis reattachment.
| Project/Area Number |
15K15547
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
Saito Naoto 信州大学, 学術研究院保健学系, 教授 (80283258)
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| Co-Investigator(Kenkyū-buntansha) |
中山 昇 信州大学, 学術研究院工学系, 准教授 (80336445)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKIZAWA Takashi 信州大学, 医学部附属病院, 医員 (40748109)
HANIU Hisao 信州大学, 学術研究院医学系, 准教授 (30252050)
TANAKA Manabu 信州大学, 医学部附属病院, 医員 (30723069)
AOKI Kaoru 信州大学, 医学部, 准教授 (30467170)
OKAMOTO Masanori 信州大学, 医学部附属病院, 診療助教 (50596781)
AJIMA Kumiko 信州大学, 先鋭領域融合研究群バイオメディカル研究所, 研究員 (70584051)
SOBAJIMA Atsushi 信州大学, 医学部附属病院, 医員 (00770760)
KAMANAKA Takayuki 信州大学, 医学部附属病院, 医員 (30791884)
TAKANASHI Seiji 信州大学, 医学部附属病院, 医員 (70596783)
KOBAYASHI Shinsuke 信州大学, 医学部附属病院, 医員 (40624705)
NOMURA Hiroki 信州大学, 医学部附属病院, 医員 (40646543)
YOSHIDA Kazushige 信州大学, 医学部附属病院, 医員 (60770774)
KATO Hiroyuki 信州大学, 学術研究院医学系, 教授 (40204490)
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| Research Collaborator |
KURODA Chika
OKANO Satomi
ISHIDA Haruka
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 骨折 / 骨移植 / 骨再生 / エンテーシス / 四肢機能再建学 |
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| Outline of Final Research Achievements |
Titanium fiber paper, which is prepared by molding titanium fibers into plates by simultaneously applying compression and shear stress at normal room temperature to retain the original fiber shape, can exhibit an elastic modulus similar to that of bone cortex and form a porous structure suitable for cell adhesion. We combined titanium fiber paper with osteoblasts differentiated from bone marrow mesenchymal stem cells and showed that the paper was better able to facilitate bone tissue repair than conventional titanium plates when implanted into rat bone defects. Also capable of being used in close contact with bone for long periods of time and promoting bone repair, titanium fiber paper has a wide range of potential applications and is expected to make great contributions to the clinical management of bone diseases, including bone fracture repair and bone regenerative medicine.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Titanium fiber plates for bone tissue repair.2017
Author(s)
Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, and Saito N.
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Journal Title
Advanced Materials.
Volume: 30
Issue: 4
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] チタンペーパーの骨再生における足場材としての有用性の検討（その2）2016
Author(s)
滝沢崇, 齋藤直人, 中山昇, 羽二生久夫, 青木薫, 岡本正則, 田中学, 傍島淳, 吉田和薫, 大石歩, 安嶋久美子
Organizer
第31回日本整形外科学会基礎学術集会
Place of Presentation
福岡国際会議場、福岡
Year and Date
2016-10-13
Related Report
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[Presentation] チタンペーパーの骨再生における足場材としての有用性の検討2015
Author(s)
滝沢崇, 田中学, 齋藤直人, 羽二生久夫, 中山昇, 青木薫, 岡本正則, 高梨誠司, 小林伸輔, 野村博紀, 加藤博之
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山国際会議場（富山県富山市）
Year and Date
2015-10-22
Related Report
